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Intrinsic role of coagulase negative staphylococci norA-like efflux system in fluoroquinolones resistance

Department of Diagnostics and Public Health, University of Verona, Verona, Italy

Topical Section: Resistance of Staphylococcus

NorA is a Staphylococcus aureus multidrug transporter that exports structurally distinct compounds including fluoroquinolones. In this study norA-like genes of Staphylococcus epidermidis (norASEP) and Staphylococcus haemolyticus (norASHAE) were identified and sequenced. The nucleotide identity of norASEP and norASHAE with norA was 75.3 and 74.1%, respectively, and the amino acid identity 87.7 and 86%, respectively. Inactivation of norASEP increased the ciprofloxacin susceptibility of E. coli DH5α carrying the pB SK 198 norASEP EZ cat norASEP plasmid.
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Keywords S. epidermidis; NorA-like gene; efflux pumps; S. haemolyticus; coagulase negative staphylococci

Citation: Ligozzi Marco, Galia Liliana, Bertoncelli Anna, Mazzariol Annarita. Intrinsic role of coagulase negative staphylococci norA-like efflux system in fluoroquinolones resistance. AIMS Microbiology, 2017, 3(4): 908-914. doi: 10.3934/microbiol.2017.4.908


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This article has been cited by

  • 1. Daria Nicolosi, Diana Cinà, Concettina Di Naso, Floriana D’Angeli, Mario Salmeri, Carlo Genovese, Antimicrobial Resistance Profiling of Coagulase-Negative Staphylococci in a Referral Center in South Italy: A Surveillance Study, The Open Microbiology Journal, 2020, 14, 1, 91, 10.2174/1874285802014010091

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Copyright Info: 2017, Mazzariol Annarita, et al., licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution Licese (http://creativecommons.org/licenses/by/4.0)

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