AIMS Medical Science, 2019, 6(3): 250-259. doi: 10.3934/medsci.2019.3.250.

Research article

Export file:

Format

  • RIS(for EndNote,Reference Manager,ProCite)
  • BibTex
  • Text

Content

  • Citation Only
  • Citation and Abstract

Investigating the relationship between ultrasound measured optic nerve sheath diameter and preeclampsia

1 Assistant Professor of Radiology, Guilan University of Medical Sciences, Rasht, Iran
2 Senior Radiology Resident, Guilan University of Medical Sciences, Rasht, Iran
3 Professor of Obstetrics and Gynecology, Guilan University of Medical Sciences, Rasht, Iran
4 Professor of Community Medicine, Guilan University of Medical Sciences, Rasht, Iran

Background: Increased intracranial pressure (ICP) is one of the main consequences of preeclampsia, which could be manifested by a change in the optic nerve sheath diameter as a radiologic and clinical sign. However, the effect of preeclampsia on the ultrasound measured optic nerve sheath diameter (ONSD) and its possible applications are rarely investigated. The aim of this study was to determine the relationship between ultrasound measured optic nerve sheath diameter and the risk of preeclampsia. Methods: This case-control study was performed on 38 pregnant women with normal blood pressure and 38 pregnant women with preeclampsia in Alzahra hospital in Rasht during 2018. A checklist was used to record demographic and clinical data. Measurements were made using a high resolution transducer, by placing the focal point and a cursor line at 3 mm behind the globe, perpendicular to the optic nerve axis (measuring the mean of two eyes). Data were analyzed by SPSS software version 21. Results: The mean age of patients with preeclampsia and normal pregnant women were 31.42 ± 6.2 years and 29.76 ± 3.46 years, respectively. Differences in gravidity (P = 0.854) and the history of hypertension (P = 0.946) in both groups were not statistically significant (P < 0.05). The mean optic nerve sheath diameter in women with preeclampsia was significantly higher than pregnant women with normal blood pressure (P = 0.001). The area under the ROC curve for the ONSD was 0.82 and the cut-off point for this index was calculated as 4.55 mm, which at this point, sensitivity and specificity were 78.9% and 73.7%, respectively. Conclusion: There was a relationship between the risk of preeclampsia and ONSD, in the way that the ONSD in preeclampsia patients was higher than that of normal subjects. However, the mean ONSD in two groups of mild and severe preeclampsia were not significantly different.
  Figure/Table
  Supplementary
  Article Metrics

Keywords preeclampsia; ultrasound; optics nerve sheath; pregnant women

Citation: Sima Fallah Arzpeyma, Pooya Bahari Khorram, Maryam Asgharnia, Zahra Mohtasham-Amiri. Investigating the relationship between ultrasound measured optic nerve sheath diameter and preeclampsia. AIMS Medical Science, 2019, 6(3): 250-259. doi: 10.3934/medsci.2019.3.250

References

  • 1. Duhig K, Vandermolen B, Shennan A (2018) Recent advances in the diagnosis and management of pre-eclampsia. F1000Res 7: 242.    
  • 2. ACOG (2013) Hypertension in pregnancy. Report of the American college of obstetricians and gynecologists' task force on hypertension in pregnancy. Obstet Gynecol 122: 1122–1131.
  • 3. Fayyaz S, Agrawal N, Yadav P, et al. (2018) Can high first trimester NLR and PLR is early predictor for preeclampsia ?: An experience of single tertiary care center. Arch Reprod Med Sex Health 1: 3–7.
  • 4. Peres GM, Mariana M, Cairrão E (2018) Pre-Eclampsia and eclampsia: An update on the pharmacological treatment applied in Portugal. J Cardiovasc Dev Dis 5: pii: E3.
  • 5. Bokslag A, van Weissenbruch M, Mol BW, et al. (2016) Preeclampsia; short and long-term consequences for mother and neonate. Early Hum Dev 102: 47–50.    
  • 6. Ghulmiyyah L, Sibai B (2012) Maternal mortality from preeclampsia/eclampsia. Semin Perinatol 36: 56–59.    
  • 7. Grotegut CA (2016) Prevention of preeclampsia. J Clin Invest 126: 4396–4398.    
  • 8. Safari M, Yazdanpanah B (2003) Preeclampsia and maternal and fetal side effects prevalence in women visiting maternity of Yasuj Imam sajjad hospital. J Shahrekord Univ Med Sci 5: 47–53.
  • 9. Anderson UD, Gram M, Åkerström B, et al. (2015) First trimester prediction of preeclampsia. Curr Hypertens Rep 17: 1–8.    
  • 10. Jadli A, Sharma N, Damania K, et al. (2015) Promising prognostic markers of preeclampsia: New avenues in waiting. Thromb Res 136: 189–195.    
  • 11. Brunelli VB, Prefumo F (2015) Quality of first trimester risk prediction models for pre-eclampsia: A systematic review. BJOG 122: 904–914.    
  • 12. Vahidroodsari F, Ayati S, Ebrahimimonfared M (2009) Before pregnancy BMI effect on incident of pregnancy blood pressure and preeclampsia. J Babol Med Sc Univ 11: 49–53.
  • 13. Nasiriamiri F, Aghajanidelavar M, Mohammadpourtahmtan RA (2009) Survey on mean arterial pressure diagnostic value in second three month pregnancy in preeclampsia prediction. J Mazandaran Univ Med Sci 45: 67–73.
  • 14. Ferro F, Rocha E, Nobrega L, et al. (2016) Transorbital ultrasonographic measurement of the optic nerve sheath diameter in preeclampsia [24J]. Obst Gyn 127: 87.
  • 15. Dehnadi Moghadam A, Alizadeh A, Yousefzadeh Chabok SH, et al. (2015) Evaluation of correlation between optic nerve sheath diameter and intracranial pressure in patients with head trauma. J Guilan Univ Med Sci 23: 44–49.
  • 16. Sekhon MS, Griesdale DE, Robba C, et al. (2014) Optic nerve sheath diameter on computed tomography is correlated with simultaneously measured intracranial pressure in patients with severe traumatic brain injury. Intensive Care Med 40: 1267–1274.    
  • 17. Whiteley JR, Taylor J, Henry M, et al. (2015) Detection of elevated intracranial pressure in robot-assisted laparoscopic radical prostatectomy using ultrasonography of optic nerve sheath diameter. J Neurosurg Anesthesiol 27: 155–159.    
  • 18. Dip F, Nguyen D, Sasson M, et al. (2016) The relationship between intracranial pressure and obesity: An ultrasonographic evaluation of the optic nerve. Surg Endosc 30: 2321–2325.    
  • 19. Gagnon A, Wilson RD (2008) Obstetrical complications associated with abnormal maternal serum markers analytes. J Obstet Gynaecol Can 30: 918–932.    
  • 20. Ortega J, Urias E, Arteaga C (2015) Comparative study measuring optic nerve sheath diameter by transorbital ultrasound in healthy women, pregnant women and pregnant with preeclampsia/eclampsia. Intensive Care Med Exp 3: A992.    
  • 21. Cuningham FG, Gant NF, Leveno KJ, et al. (2001) Williams obstetrics. 21st ed. New York: Mc Graw-Hill, 568–569.
  • 22. Davaryari N, Razavi Panah R, Homayoon Mehr S, et al. (2011) A comparison of serum level of selenium in women with preeclampsia and normal pregnant women. Med J Mashhad Univ Med Sci 54: 80–85.
  • 23. Dargahi R, Shahbazzadegan S, Naghizadeh-Baghi A, et al. (2018) Expression levels of Drosha and Dicer enzymes and DGCR8 protein in pre-eclamptic patients. Iran J Obstet Gynecol Infertility 20: 40–49.
  • 24. Samiee Rad F, Jahani Hashemi H, Sofiabadi M, et al. (2017) Evaluation of severity of preeclampsia with mother's serum high sensitive C-reactive protein (Hs-CRP). SSU_J 25: 556–563.
  • 25. Nikpour S, Atarodi Kashani Z, Mokhtarshahi S, et al. (2007) Study of the correlation of the consumption of Vitamin C-Rich foods with preeclampsia and eclampsia in women referred to Shahid Akbar Abadi Hospital in Tehran, 2004. Razi J Med Sci 14: 179–192.
  • 26. Tessema GA, Tekeste A, Ayele TA (2015) Preeclampsia and associated factors among pregnant women attending antenatal care in Dessie referral hospital, Northeast Ethiopia: A hospital-based study. BMC Pregnancy Childbirth 15: 73.    
  • 27. Singh SK, Bhatia K (2018) Ultrasonographic optic nerve sheath diameter as a surrogate measure of raised intracranial pressure in severe pregnancy-induced hypertension patients. Anesth Essays Res 12: 42–46.    
  • 28. Goeres P, Zeiler FA, Unger B, et al. (2016) Ultrasound assessment of optic nerve sheath diameter in healthy volunteers. J Crit Care 31: 168–71.    
  • 29. Brzan Simenc G, Ambrozic J, Prokselj K, et al. (2018) Ocular ultrasonography for diagnosing increased intracranial pressure in patients with severe preeclampsia. Int J Obstet Anesth 36: 49–55.    

 

Reader Comments

your name: *   your email: *  

© 2019 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution Licese (http://creativecommons.org/licenses/by/4.0)

Download full text in PDF

Export Citation

Copyright © AIMS Press All Rights Reserved