AIMS Medical Science, 2017, 4(2): 233-240. doi: 10.3934/medsci.2017.2.233

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Lack of Association between Human µ-Opioid Receptor (OPRM1) Gene Polymorphisms and Heroin Addiction in A Sample of Southeast Iranian Population

Mansour Shakiba, Mohammad Hashemi, Zahra Rahbari, Salah Mahdar, Hiva Danesh, Fatemeh Bizhani, Gholamreza Bahari

1 Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran;
2 Department of Psychiatry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran;
3 Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran;
4 Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

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It has been proposed that genetic factors account for 30%–50% of the risk for cocaine and heroin addiction. The present study was aimed to find out the impact of µ-opioid receptor gene (OPRM1) rs1799971 A > G and rs9479757 polymorphisms on heroin dependence in a sample of southeast Iranian population. This case-control study was done on 123 heroin addicts and 140 non-addicts Iranian male. Genomic DNA was extracted from peripheral blood cells using salting out method. Genotyping of OPRM1 rs1799971 and rs9479757 polymorphisms were performed using PCR-RFLP method. Overall, our results did not support an association between OPRM1 variants and risk of heroin dependence in a sample of southeast Iranian population. Further studies with larges sample sizes and different ethnicities are required to validate our findings.
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