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Role of PTH in the Renal Handling of Phosphate

1 Department of Physiology & Biophysics, University of Louisville, Louisville, KY, USA;
2 Department of Medicine, University of Louisville, Louisville, KY, USA;
3 Robley Rex VAMC, Louisville, KY, USA;
4 Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA

Special Issues: Developmental and Physiological roles of PTH ligands and receptors: New Insights

Parathyroid hormone (PTH) is one of the primary phosphaturic hormones in the body. The type IIa sodium-phosphate cotransporter (Npt2a) is expressed in the apical membrane of the renal proximal tubule and is responsible for the reabsorption of the majority of the filtered load of phosphate. PTH acutely induces phosphaturia through the rapid stimulation of endocytosis of Npt2a and its subsequent lysosomal degradation. This review focuses on the homeostatic mechanisms underlying serum phosphate, with particular focus on the regulation of the phosphate transporter Npt2a by PTH within the renal proximal tubule. Additionally, the proximal tubular PTH-stimulated signaling events as they relate to PTH-induced phosphaturia are also highlighted. Lastly, we discuss recent findings by our lab concerning novel regulatory mechanisms of PTH-mediated reductions in Npt2a expression.
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Keywords phosphate; PTH; GPCR signaling; renal proximal tubule; Npt2a

Citation: Rebecca D. Murray, Eleanor D. Lederer, Syed J. Khundmiri. Role of PTH in the Renal Handling of Phosphate. AIMS Medical Science, 2015, 2(3): 162-181. doi: 10.3934/medsci.2015.3.162


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