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Analysis of a stochastic IVGTT glucose-insulin model with time delay

1 School of Mathematics and Statistics, Xinyang Normal University, Xinyang 464000, China
2 Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY 40202, USA
3 Department of Mathematics, University of Louisville, Louisville, KY 40292, USA

Diabetes mellituse has been one of the major diseases in the world due to the high percentage of diabetics in the global population and the increasing growth rate of its onset. Identifying individual physiological characteristics, e.g., insulin sensitivity and glucose effectiveness and others, is extremely important in developing effective drugs and investigating genetic pathways causing the defects in these physiological responses. Intravenous glucose tolerance test (IVGTT) is such a protocol to determine an individual insulin sensitivity and glucose effectiveness indices. In this paper, we propose a stochastic delay differential equation model for the IVGTT protocol attempting to develop a method to increase the accuracy of parameter estimation. We first study the existence and uniqueness of the global positive solution and its asymptotic behavior of the stochastic path close to the steady state of the corresponding deterministic model. Then we develop a maximum likelihood estimation method to estimate the parameters involved in the proposed model. Our simulation studies numerically confirm our theoretical findings and demonstrate that the proposed model with estimated parameters can improve the fitness of clinical data.
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Keywords IVGTT model; stochastic perturbation; time delay; Itô’s formula; MLE method

Citation: Xiangyun Shi, Qi Zheng, Jiaoyan Yao, Jiaxu Li, Xueyong Zhou. Analysis of a stochastic IVGTT glucose-insulin model with time delay. Mathematical Biosciences and Engineering, 2020, 17(3): 2310-2329. doi: 10.3934/mbe.2020123


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