Optimal control problems with time delays: Two case studies in biomedicine

  • Received: 30 April 2017 Accepted: 18 March 2018 Published: 01 October 2018
  • MSC : Primary: 49K15, 49M37; Secondary: 92C50

  • There exists an extensive literature on delay differential models in biology and biomedicine, but only a few papers study such models in the framework of optimal control theory. In this paper, we consider optimal control problems with multiple time delays in state and control variables and present two applications in biomedicine. After discussing the necessary optimality conditions for delayed optimal control problems with control-state constraints, we propose discretization methods by which the delayed optimal control problem is transformed into a large-scale nonlinear programming problem. The first case study is concerned with the delay differential model in [21] describing the tumour-immune response to a chemo-immuno-therapy. Assuming $ L^1$-type objectives, which are linear in control, we obtain optimal controls of bang-bang type. In the second case study, we introduce a control variable in the delay differential model of Hepatitis B virus infection developed in [7]. For $ L^1$-type objectives we obtain extremal controls of bang-bang type.

    Citation: Laurenz Göllmann, Helmut Maurer. Optimal control problems with time delays: Two case studies in biomedicine[J]. Mathematical Biosciences and Engineering, 2018, 15(5): 1137-1154. doi: 10.3934/mbe.2018051

    Related Papers:

  • There exists an extensive literature on delay differential models in biology and biomedicine, but only a few papers study such models in the framework of optimal control theory. In this paper, we consider optimal control problems with multiple time delays in state and control variables and present two applications in biomedicine. After discussing the necessary optimality conditions for delayed optimal control problems with control-state constraints, we propose discretization methods by which the delayed optimal control problem is transformed into a large-scale nonlinear programming problem. The first case study is concerned with the delay differential model in [21] describing the tumour-immune response to a chemo-immuno-therapy. Assuming $ L^1$-type objectives, which are linear in control, we obtain optimal controls of bang-bang type. In the second case study, we introduce a control variable in the delay differential model of Hepatitis B virus infection developed in [7]. For $ L^1$-type objectives we obtain extremal controls of bang-bang type.


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    [1] [ B. Buonomo,M. Cerasuolo, The effect of time delay in plant-pathogen interactions with host demography, Math. Biosciences and Engineering, 12 (2015): 473-490.
    [2] [ C. Büskens, Optimierungsmethoden und Sensitivitätsanalyse für optimale Steuerprozesse mit Steuer- und Zustands-Beschränkungen, PhD thesis, Institut für Numerische Mathematik, Westfälische Wilhelms-Universität Münster, Germany, 1998.
    [3] [ C. Büskens,H. Maurer, SQP methods for solving optimal control problems with control and state constraints: adjoint variables, sensitivity analysis and real-time control, J. Comput. Appl. Math., 120 (2000): 85-108.
    [4] [ C. Büskens and M. Gerdts, WORHP: Large-Scale Sparse Nonlinear Optimization Solver, http://www.worhp.de.
    [5] [ Q. Chai,R. Loxton,K. L. Teo,C. Yang, A class of optimal state-delay control Problems, Nonlinear Analysis: Real World Applications, 14 (2013): 1536-1550.
    [6] [ R. V. Culshaw,S. Ruan, A delay-differential equation model of HIV infection of CD4+ T-cells, Mathematical Biosciences, 165 (2000): 27-39.
    [7] [ S. Eikenberry,S. Hews,J. D. Nagy,Y. Kuang, The dynamics of a delay model of Hepatitis B virus infection with logistic hepatocyte growth, Mathematical Biosciences, 6 (2009): 283-299.
    [8] [ R. Fourer, D. M. Gay and B. W. Kernighan, AMPL: A Modeling Language for MathematicalProgramming, The Scientific Press, South San Francisco, California, 1993.
    [9] [ L. Göllmann,D. Kern,H. Maurer, Optimal control problems with delays in state and control and mixed control-state constraints, Optimal Control Applications and Methods, 30 (2009): 341-365.
    [10] [ L. Göllmann,H. Maurer, Theory and applications of optimal control problems with multiple time-delays, Journal of Industrial and Management Optimization, 10 (2014): 413-441.
    [11] [ T. Guinn, Reduction of delayed optimal control problems to nondelayed problems, Journal of Optimization Theory and Applications, 18 (1976): 371-377.
    [12] [ R. F. Hartl,S. P. Sethi,R. G. Vickson, A survey of the maximum principles for optimal control problems with state constraints, SIAM Review, 37 (1995): 181-218.
    [13] [ M. R. Hestenes, Calculus of Variations and Optimal Control Theory, John Wiley, New York, 1966.
    [14] [ S. C. Huang, Optimal Control problems with retardations and restricted phase coordinates, Journal of Optimization Theory and Applications, 3 (1969): 316-360.
    [15] [ J. Klamka,H. Maurer,A. Swierniak, Local controllability and optimal control for a model of combined anticancer therapy with control delays, Mathematical Biosciences and Engineering, 14 (2017): 195-216.
    [16] [ Y. Kuang, Delay Differential Equations with Applications in Population Dynamics, Academic Press, San Diego, 1993.
    [17] [ H. Maurer,C. Büskens,J.-H. R. Kim,Y. Kaya, Optimization methods for the verification of second-order sufficient conditions for bang-bang controls, Optimal Control Methods and Applications, 26 (2005): 129-156.
    [18] [ R. M. May, Time-delay versus stability in population models with two and three tropic levels, Ecology, 54 (1973): 315-325.
    [19] [ N. P. Osmolovskii and H. Maurer, Applications to Regular and Bang-Bang Control: Second-Order Necessary and Sufficient Optimality Conditions in Calculus of Variations and Optimal Control, SIAM Advances in Design and Control, Vol. DC 24, SIAM Publications, Philadelphia, 2012.
    [20] [ L. S. Pontryagin, V. G. Boltyanskii, R. V. Gamkrelidze and E. F. Mishchenko, The Mathematical Theory of Optimal Processes, Translation by K. N. Trirogoff, Wiley, New York, 1962.
    [21] [ F. Rihan, D. H. Abdelrahman, F. Al-Maskari, F. Ibrahim and M. A. Abdeen, Delay differential model for tumour-immune-response with chemoimmunotherapy and optimal control. Computational and Mathematical Methods in Medicine, Hindawi Publishing Corporation, Vol. 2014, Article ID 982978, (2014).
    [22] [ H. Schättler,U. Ledzewicz,H. Maurer, Sufficient conditions for strong local optimality in optimal control problems with L2-type objectives and control constraints, Discrete Contin. Dyn. Syst. Ser. B, 19 (2014): 2657-2679.
    [23] [ C. Silva,H. Maurer,D.F.M. Torres, Optimal control of a tuberculosis model with state and control delays, Mathematical Biosciences and Engineering, 14 (2017): 321-337.
    [24] [ C. T. Sreeramareddy,K. V. Panduru,J. Menten,J. V. den Ende, Time delays in diagnosis of pulmonary tuberculosis: A systematic review of literature, BMC Infectious Diseases, 9 (2009): 91-100.
    [25] [ J. Stoer and R. Bulirsch, Introduction ot Numerical Analysis, Third Edition, Texts in Applied Mathematics, Springer-Verlag, Berlin, 1990.
    [26] [ D. G. Storla,S. Yimer,G. A. Bjune, A systematic review in delay in the diagnosis and treatment of tuberculosis, BMC Public Health, 8 (2008): p15.
    [27] [ P. van den Driessche, Some Epidemiological Models with Delays, Report DMS-679-IR, University of Victoria, Department of Mathematics, 1994.
    [28] [ A. Wächter,L. T. Biegler, On the implementation of an interior-point filter line-search algorithm for large-scale nonlinear programming, Mathematical Programming, 106 (2006): 25-57.
    [29] [ H. Yang,J. Wei, Global behaviour of a delayed viral kinetic model with general incidence rate, Discrete Contin. Dyn. Syst. Ser. B, 20 (2015): 1573-1582.
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