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A bacteriophage model based on CRISPR/Cas immune system in a chemostat

. Key Laboratory of Eco-environments in Three Gorges Reservoir Region, School of Mathematics and Statistics, Southwest University, Chongqing 400715, China

Clustered regularly interspaced short palindromic repeats (CRISPRs) along with Cas proteins are a widespread immune system across bacteria and archaea. In this paper, a mathematical model in a chemostat is proposed to investigate the effect of CRISPR/Cas on the bacteriophage dynamics. It is shown that the introduction of CRISPR/Cas can induce a backward bifurcation and transcritical bifurcation. Numerical simulations reveal the coexistence of a stable infection-free equilibrium with an infection equilibrium, or a stable infection-free equilibrium with a stable periodic solution.

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Keywords Bacteriophage; bifurcation; bistability; backward; evolution

Citation: Mengshi Shu, Rui Fu, Wendi Wang. A bacteriophage model based on CRISPR/Cas immune system in a chemostat. Mathematical Biosciences and Engineering, 2017, 14(5&6): 1361-1377. doi: 10.3934/mbe.2017070


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This article has been cited by

  • 1. WENDI WANG, DYNAMICS OF BACTERIA-PHAGE INTERACTIONS WITH IMMUNE RESPONSE IN A CHEMOSTAT, Journal of Biological Systems, 2017, 25, 04, 697, 10.1142/S0218339017400010

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