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Multi-host transmission dynamics of schistosomiasis and its optimal control

1. Department of Applied Mathematics, Nanjing University of Science and Technology, Nanjing, 210094
2. LAboratory of Mathematical Parallel Systems (LAMPS), Centre for Disease Modeling, Department of Mathematics and Statistics, York University, Toronto, Ontario, M3J 1P3

In this paper we formulate a dynamical model to study the transmission dynamics of schistosomiasis in humans and snails. We also incorporate bovines in the model to study their impact on transmission and controlling the spread of Schistosoma japonicum in humans in China. The dynamics of the model is rigorously analyzed by using the theory of dynamical systems. The theoretical results show that the disease free equilibrium is globally asymptotically stable if $\mathcal R_0<1 and="" if="" mathcal="" r_0="">1$ the system has only one positive equilibrium. The local stability of the unique positive equilibrium is investigated and sufficient conditions are also provided for the global stability of the positive equilibrium. The optimal control theory are further applied to the model to study the corresponding optimal control problem. Both analytical and numerical results suggest that: (a) the infected bovines play an important role in the spread of schistosomiasis among humans, and killing the infected bovines will be useful to prevent transmission of schistosomiasis among humans; (b) optimal control strategy performs better than the constant controls in reducing the prevalence of the infected human and the cost for implementing optimal control is much less than that for constant controls; and (c) improving the treatment rate of infected humans, the killing rate of the infected bovines and the fishing rate of snails in the early stage of spread of schistosomiasis are very helpful to contain the prevalence of infected human case as well as minimize the total cost.
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Keywords optimal control.; Multi-hosts; transmission dynamics; stability; schistosomiasis

Citation: Chunxiao Ding, Zhipeng Qiu, Huaiping Zhu. Multi-host transmission dynamics of schistosomiasis and its optimal control. Mathematical Biosciences and Engineering, 2015, 12(5): 983-1006. doi: 10.3934/mbe.2015.12.983

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This article has been cited by

  • 1. Chunxiao Ding, Yun Sun, Yuanguo Zhu, A schistosomiasis compartment model with incubation and its optimal control, Mathematical Methods in the Applied Sciences, 2017, 40, 14, 5079, 10.1002/mma.4372
  • 2. Chunxiao Ding, Nana Tao, Yun Sun, Yuanguo Zhu, The effect of time delays on transmission dynamics of schistosomiasis, Chaos, Solitons & Fractals, 2016, 91, 360, 10.1016/j.chaos.2016.06.017
  • 3. Chunxiao Ding, Yun Sun, Yuanguo Zhu, A NN-Based Hybrid Intelligent Algorithm for a Discrete Nonlinear Uncertain Optimal Control Problem, Neural Processing Letters, 2017, 45, 2, 457, 10.1007/s11063-016-9536-8
  • 4. Chunxiao Ding, Wenjian Liu, Yun Sun, Yuanguo Zhu, A delayed Schistosomiasis transmission model and its dynamics, Chaos, Solitons & Fractals, 2019, 118, 18, 10.1016/j.chaos.2018.11.005
  • 5. Tao Feng, Zhipeng Qiu, Yi Song, Global analysis of a vector-host epidemic model in stochastic environments, Journal of the Franklin Institute, 2019, 10.1016/j.jfranklin.2019.01.033
  • 6. Zhipeng Qiu, Xuerui Wei, Chunhua Shan, Huaiping Zhu, Monotone dynamics and global behaviors of a West Nile virus model with mosquito demographics, Journal of Mathematical Biology, 2019, 10.1007/s00285-019-01442-4

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Copyright Info: 2015, Chunxiao Ding, et al., licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution Licese (http://creativecommons.org/licenses/by/4.0)

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