Combining robust state estimation with nonlinear model predictive control to regulate the acute inflammatory response to pathogen

  • Received: 01 September 2014 Accepted: 29 June 2018 Published: 01 June 2015
  • MSC : Primary: 92C50, 93C15; Secondary: 93C83.

  • The inflammatory responseaims to restore homeostasis by means of removing a biological stress, such as an invading bacterial pathogen.In cases of acute systemic inflammation, the possibility of collateral tissuedamage arises, which leads to a necessary down-regulation of the response.A reduced ordinary differential equations (ODE) model of acute inflammation was presented and investigated in [10]. That system contains multiple positive and negative feedback loops and is a highly coupled and nonlinear ODE. The implementation of nonlinear model predictive control (NMPC) as a methodology for determining proper therapeutic intervention for in silico patients displaying complex inflammatory states was initially explored in [5]. Since direct measurements of the bacterial population and the magnitude of tissue damage/dysfunction are not readily available or biologically feasible, the need for robust state estimation was evident. In this present work, we present resultson the nonlinear reachability of the underlying model, and then focus our attention on improving the predictability of the underlying model by coupling the NMPC with a particle filter. The results, though comparable to the initial exploratory study, show that robust state estimation of this highly nonlinear model can provide an alternative to prior updating strategies used when only partial access to the unmeasurable states of the system are available.

    Citation: Gregory Zitelli, Seddik M. Djouadi, Judy D. Day. Combining robust state estimation with nonlinear model predictive control to regulate the acute inflammatory response to pathogen[J]. Mathematical Biosciences and Engineering, 2015, 12(5): 1127-1139. doi: 10.3934/mbe.2015.12.1127

    Related Papers:

  • The inflammatory responseaims to restore homeostasis by means of removing a biological stress, such as an invading bacterial pathogen.In cases of acute systemic inflammation, the possibility of collateral tissuedamage arises, which leads to a necessary down-regulation of the response.A reduced ordinary differential equations (ODE) model of acute inflammation was presented and investigated in [10]. That system contains multiple positive and negative feedback loops and is a highly coupled and nonlinear ODE. The implementation of nonlinear model predictive control (NMPC) as a methodology for determining proper therapeutic intervention for in silico patients displaying complex inflammatory states was initially explored in [5]. Since direct measurements of the bacterial population and the magnitude of tissue damage/dysfunction are not readily available or biologically feasible, the need for robust state estimation was evident. In this present work, we present resultson the nonlinear reachability of the underlying model, and then focus our attention on improving the predictability of the underlying model by coupling the NMPC with a particle filter. The results, though comparable to the initial exploratory study, show that robust state estimation of this highly nonlinear model can provide an alternative to prior updating strategies used when only partial access to the unmeasurable states of the system are available.


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    [1] New Eng J Med, 369 (2013), 840-851.
    [2] Proceedings of the $52^{nd}$ IEEE Conference on Decision and Control, Florence, Italy, December 10-13 (2013), 3373-3378.
    [3] Springer-Verlag London, Ltd., London, 1999.
    [4] American Mathematical Society, Providence, RI, 2007.
    [5] Math Biosci Eng, 7 (2010), 739-763.
    [6] J Exp Med, 174 (1991), 1209-1220.
    [7] Comput. Biol. Med., 38 (2008), 339-347.
    [8] 9th International Symposium on Dynamics and Control of Process Systems, 9 (2010), 272-277.
    [9] Springer-Verlag, New York, 1990.
    [10] J Theor Bio, 242 (2006), 220-236.
    [11] Wiley-Interscience, Hoboken, NJ, 2006.
    [12] Oxford University Press, Oxford, 2008.
    [13] Birkhäuser Boston, Inc, Boston, MA, 1992.
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