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Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha?

1. MBI, Ohio State University, Columbus, OH 43210
2. Department of Mathematics, University of Botswana, Gaborone

We consider a model incorporating the influence of innate and adaptive immune responses on malaria pathogenesis. By calculating the model reproduction number for a special representation of cytokine interaction, we have shown that the cytokine tumour necrosis factor-$\alpha$ can be administered to inhibit malaria infection. We have also found that if the cytokine $F^*$ and a generic drug of efficacy $\epsilon$ are administered as dual therapy then clearance of the parasite can be achieved even for a generic drug of low efficacy. Our study is recommending administration of dual therapy as a strategy to prevent parasites from developing resistance to malaria treatment drugs.
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Keywords cytokines.; Pathogenesis; adaptive immune response; innate immune response

Citation: Avner Friedman, Edward M. Lungu. Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha?. Mathematical Biosciences and Engineering, 2013, 10(3): 609-624. doi: 10.3934/mbe.2013.10.609

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