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Associations of CYP1A1 gene polymorphisms and risk of breast cancer in Indian women: a meta-analysis

1 Center for Research and Development, Angeles University Foundation, Angeles City 2009, Philippines;
2 Genotoxicity Laboratory, Toxicology Division, Central Drug Research Institute, Lucknow 226 001, Utar Pradesh, India;
3 College of Allied Medical Profession, Angeles University Foundation, Angeles City 2009 Philippines;
4 Department of Gynecology and Obstetrics-Faculdade de Medicina do ABC, Human Reproduction and Genetics Center, Avenida Prıncipe de Gales, 821, Santo Andre, SP, 09060-650, Brazil;
5 Environmental Monitoring and Reporting Branch, Ontario Ministry of the Environment and Climate Change, 125 Resources Road, Toronto, ON, Canada M9P 3V6

Special Issues: Genetics of Breast Cancer

Reported associations of CYP1A1 polymorphisms with breast cancer have been inconsistent. In this meta-analysis examining breast cancer associations of three CYP1A1 polymorphisms (M1, M2 and M4) among Indian women may yield information that may be of clinical and epidemiological use for this particular demography. We searched MEDLINE using PubMed and Embase for association studies. From seven published case-control studies, we estimated overall associations and applied subgroup analysis to explore differential effects. All three polymorphisms exhibited overall increased risk, significant in M1 (OR 1.61-1.65, p = 0.04) and M4 (OR 2.02-3.92, p = 0.02-0.04). Differential effects were observed only in the M1 polymorphism where M1 effects were significant in South Indians (OR 2.20-4.34, p < 0.0001) but not the North population, who were at reduced risk (OR 0.64-0.77, p = 0.03-0.55). These populations were not materially different in regard to M2 and M4 as did the women stratified by menopausal status. In this meta-analysis, M1 and M4 effects may render Indian women susceptible, but may be limited by heterogeneity of the studies. Differential effects of the M1 polymorphism in breast cancer render South Indians susceptible compared to those in the North.
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