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Context-dependent interplay between Hippo and JNK pathway in Drosophila

Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Special Issues: Drosophila models of tumourigenesis

Both Hippo and JNK signaling have well-established roles in regulating many physiological processes, including cell proliferation, growth, survival, and migration. An increasing body of evidence shows that dysregulation of either Hippo or JNK pathway would lead to tumorigenesis. Recently, studies in Drosophila has coupled Hippo with JNK pathway in numerous ways ranging from tissue regeneration to growth control. In this review, I provide an overview of the current understanding of crosstalk between Hippo and JNK pathway in Drosophila, and discuss their context-dependent interactions in gut homeostasis, regeneration, cell competition and migration.
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Keywords Hippo; JNK; Drosophila; cell competition; ISC; migration

Citation: Xianjue Ma. Context-dependent interplay between Hippo and JNK pathway in Drosophila. AIMS Genetics, 2014, 1(1): 20-33. doi: 10.3934/genet.2014.1.20


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