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Prenatal exposures and exposomics of asthma

1 Departments of Environmental Health Sciences, Epidemiology, and Biostatistics, University at Albany, School of Public Health, One University Place, Rm 153, Rensselaer, NY 12144-3456, USA;
2 Chemical Engineering Department, Faculty of Science and Engineering, Thornton Science Park, University of Chester, Chester, CH2 4NU, UK;
3 Wadsworth Center, New York State Department of Health, Center for Medical Sciences, Rm 1155, 150 New Scotland Ave. Albany, NY 12201, USA

Special Issues: Systems Biology and Prenatal Exposure

This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental media.
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