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Double casting prototyping with a thermal aging step for fabrication of 3D microstructures in poly(dimethylsiloxane)

1 Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland
2 Institute of Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland

Topical Section: Lab-on-a-Chip, Microfluidics & Microarrays

The paper describes a cheap and accessible technique of a poly(dimethylsiloxane) (PDMS) master treatment by thermal aging as a step of double casting microfabrication process. Three-dimensional PDMS microstructures could have been achieved using this technique. It was proved, that thermal aging changes nanotopology of a PDMS surface and thus enhances efficiency of double casting prototyping. The thermally aged PDMS master could have been used for multiple and correct replication of over 98% of the fabricated microstructures. Moreover, lack of chemical modification preserved the biocompatibility of PDMS devices. The fabricated microstructures were successfully utilized for 3D cell culture.
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Keywords PDMS; microfabrication; 3D microstructures; biocompatible materials; double casting; thermal aging

Citation: Karina Kwapiszewska, Kamil Żukowski, Radosław Kwapiszewski, Zbigniew Brzózka. Double casting prototyping with a thermal aging step for fabrication of 3D microstructures in poly(dimethylsiloxane). AIMS Biophysics, 2016, 3(4): 553-562. doi: 10.3934/biophy.2016.4.553

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Copyright Info: 2016, Karina Kwapiszewska, et al., licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution Licese (http://creativecommons.org/licenses/by/4.0)

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