A Microfluidic Device for Spatiotemporal Delivery of Stimuli to Cells

Zubaidah Ningsih; James W.M. Chon; Andrew H.A. Clayton; Zubaidah Ningsih; James W.M. Chon; Andrew H.A. Clayton

doi:10.3934/biophy.2015.2.58

AIMS Biophysics

2015, Volume 2, Issue 2: 58-72. doi: 10.3934/biophy.2015.2.58

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Research article Special Issues

A Microfluidic Device for Spatiotemporal Delivery of Stimuli to Cells

Centre for Microphotonics, Faculty of Science, Engineering and Technology, Swinburne University of Technology, John Street PO BOX 218 Hawthorn VIC 3122 Australia

Received: 10 January 2015 Accepted: 20 March 2015 Published: 30 March 2015

Living cells encounter many stimuli from the immediate environment. Receptors recognize these environmental cues and transduce signals to produce cell responses. The frequency of a signal is now emerging as an important factor determining cell responses. As a componentry system in understanding temporal stimulation, microfluidic devices allow the observation of cell behaviour under dynamic stimulation and controllable environment. In this paper we describe the design, construction and characterization of a microfluidic device suitable for cell stimulation studies.
- microfluidic,
- mixing,
- lifetime,
- spatiotemporal,
- FLIM
Citation: Zubaidah Ningsih, James W.M. Chon, Andrew H.A. Clayton. A Microfluidic Device for Spatiotemporal Delivery of Stimuli to Cells[J]. AIMS Biophysics, 2015, 2(2): 58-72. doi: 10.3934/biophy.2015.2.58

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Abstract

Living cells encounter many stimuli from the immediate environment. Receptors recognize these environmental cues and transduce signals to produce cell responses. The frequency of a signal is now emerging as an important factor determining cell responses. As a componentry system in understanding temporal stimulation, microfluidic devices allow the observation of cell behaviour under dynamic stimulation and controllable environment. In this paper we describe the design, construction and characterization of a microfluidic device suitable for cell stimulation studies.

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