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Gold nanoparticle DNA damage in radiotherapy: A Monte Carlo study

  • Received: 17 May 2016 Accepted: 21 July 2016 Published: 27 July 2016
  • This study investigated the DNA damage due to the dose enhancement of using gold nanoparticles (GNPs) as a radiation sensitizer in radiotherapy. Nanodosimetry of a photon irradiated GNP was performed with Monte Carlo simulations using Geant4-DNA (ver. 10.2) in the nanometer scale. In the simulation model, GNP spheres (with diameters of 30, 50, and 100 nm) and a DNA model were placed in a water cube (1 µm3). The GNPs were irradiated by photon beams with varying energies (50, 100, and 150 keV), which produced secondary electrons, enhancing the dose to the DNA. To investigate the dose enhancement effect at the DNA level, energy deposition to the DNA with and without the GNP were determined in simulations for calculation of the dose enhancement ratio (DER). The distance between the GNP and the DNA molecule was varied to determine its effect on the DER. Monte Carlo results were collected for three variables; GNP size, distances between the GNP and DNA molecule, and the photon beam energy. The DER was found to increase with the size of GNP and decrease with the distance between the GNP and DNA molecule. The largest DER was found to be 3.7 when a GNP (100 nm diameter) was irradiated by a 150 keV photon beam set at 30 nm from the DNA molecule. We conclude that there is significant dependency of the DER on GNP size, distance to the DNA and photon energy and have simulated those relationships.

    Citation: Chun He, James C.L. Chow. Gold nanoparticle DNA damage in radiotherapy: A Monte Carlo study[J]. AIMS Bioengineering, 2016, 3(3): 352-361. doi: 10.3934/bioeng.2016.3.352

    Related Papers:

  • This study investigated the DNA damage due to the dose enhancement of using gold nanoparticles (GNPs) as a radiation sensitizer in radiotherapy. Nanodosimetry of a photon irradiated GNP was performed with Monte Carlo simulations using Geant4-DNA (ver. 10.2) in the nanometer scale. In the simulation model, GNP spheres (with diameters of 30, 50, and 100 nm) and a DNA model were placed in a water cube (1 µm3). The GNPs were irradiated by photon beams with varying energies (50, 100, and 150 keV), which produced secondary electrons, enhancing the dose to the DNA. To investigate the dose enhancement effect at the DNA level, energy deposition to the DNA with and without the GNP were determined in simulations for calculation of the dose enhancement ratio (DER). The distance between the GNP and the DNA molecule was varied to determine its effect on the DER. Monte Carlo results were collected for three variables; GNP size, distances between the GNP and DNA molecule, and the photon beam energy. The DER was found to increase with the size of GNP and decrease with the distance between the GNP and DNA molecule. The largest DER was found to be 3.7 when a GNP (100 nm diameter) was irradiated by a 150 keV photon beam set at 30 nm from the DNA molecule. We conclude that there is significant dependency of the DER on GNP size, distance to the DNA and photon energy and have simulated those relationships.


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    [1] Baskar R, Lee KA, Yeo R, et al. (2012) Cancer and radiation therapy: current advances and future directions. Int J Med Sci 9: 193–199. doi: 10.7150/ijms.3635
    [2] Lomax ME, Folkes LK, O’Neill P (2013) Biological consequences of radiation-induced DNA damage: relevance to radiotherapy. Clin Oncol 25: 578–585. doi: 10.1016/j.clon.2013.06.007
    [3] Hosoya N, Miyagawa K (2014) Targeting DNA damage response in cancer therapy. Cancer Sci 105: 370–388. doi: 10.1111/cas.12366
    [4] Bentzen SM (2006) Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nat Rev Cancer 6: 702–713. doi: 10.1038/nrc1950
    [5] Linam J, Yang LX (2015) Recent developments in radiosensitization. Anticancer Res 35: 2479–2485.
    [6] Luo Y, Leverson JD (2005) New opportunities in chemosensitization and radiosensitization: modulating the DNA-damage response. Expert Rev Anticancer Ther 5: 333–342. doi: 10.1586/14737140.5.2.333
    [7] Chow JCL (2016) Photon and electron interactions with gold nanoparticles: a Monte Carlo study on gold nanoparticle-enhanced radiotherapy, In: Grumezescu AM (Ed.), Nanobiomaterials in medical imaging: application of nanobiomaterials, Elsevier, Amsterdam, 45–70.
    [8] Taupin F, Flaender M, Delorme R, et al. (2015) Gadolinium nanoparticles and contrast agent as radiation sensitizers. Phys Med Biol 60: 4449–4464. doi: 10.1088/0031-9155/60/11/4449
    [9] Cooper DR, Bekah D, Nadeau JL (2014) Gold nanoparticles and their alternatives for radiation therapy enhancement. Front Chem 2: 86.
    [10] Chow JCL (2015) Characteristics of secondary electrons from irradiated gold nanoparticle in radiotherapy, In: Aliofkhazraei M (Ed.) Handbook of nanoparticle, Springer, Switzerland, 1–19.
    [11] Schuemann J, Berbeco R, Chithrani DB, et al. (2015) Roadmap to clinical use of gold nanoparticles for radiation sensitization. Int J Radiat Oncol Biol Phys 64: 189–205.
    [12] Shah M, Badwalk VD, Dakshinamurthy R (2014) Biological applications of gold nanoparticles. J Nanosci Nanotechnol 14: 344–362. doi: 10.1166/jnn.2014.8900
    [13] Dorsey JF, Sun L, Joh DY, et al. (2013) Gold nanoparticles in radiation research: Potential applications for imaging and radiosensitization. Transl Cancer Res 2: 280–291.
    [14] Jeremic B, Aguerri AR, Filipovic N (2013) Radiosensitization by gold nanoparticles. Clin Trasl Oncol 15: 593–601. doi: 10.1007/s12094-013-1003-7
    [15] Kawtra D, Venugopal A, Anant S (2013) Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer. Transl Cancer Res 2: 330–342.
    [16] Thambi T, Park JH (2014) Recent advances in shell-sheddable nanoparticles for cancer therapy. J Biomed Nanotechnol 10: 1841–1862. doi: 10.1166/jbn.2014.1977
    [17] Li J, Li JJ, Zhang J (2016) Gold nanoparticle size and shape influence on osteogenesis of mesenchymal stem cells. Nanoscale 8: 7992–8007. doi: 10.1039/C5NR08808A
    [18] Regulla DF, Hieber LB, Seidenbusch M (1998) Physical and biological interface dose effects in tissue due to x-ray-induced release of secondary radiation from metallic gold surfaces. Radiat Res 150: 92–100. doi: 10.2307/3579649
    [19] Herold D, Das I, Stobbe C, et al. (2000) Gold microspheres: a selective technique for producing biologically effective dose enhancement. Int J Radiat Biol 76: 1357–1364. doi: 10.1080/09553000050151637
    [20] Hainfeld JF, Slakin DN, Smilowitz HM (2004) The use of gold nanoparticles to enhance radiotherapy in mice. Phys Med Biol 49: N309–315. doi: 10.1088/0031-9155/49/18/N03
    [21] Hainfeld JF, Dilmanian FA, Zhong Z, et al. (2010) Gold nanoparticles enhance the radiation therapy of a murine squamous cell carcinoma. Phys Med Biol 55: 3045–3059. doi: 10.1088/0031-9155/55/11/004
    [22] Cho SH (2005) Estimation of tumour dose enhancement due to gold nanoparticles during typical radiation treatments: a preliminary Monte Carlo study. Phys Med Bio 50: N163–173. doi: 10.1088/0031-9155/50/15/N01
    [23] Leung M, Chow JCL, Chithrani BD (2011) Irradiation of gold nanoparticles by x-rays: Monte Carlo simulation of dose enhancements and the spatial properties of the secondary electrons production. Med Phys 38: 624–631. doi: 10.1118/1.3539623
    [24] Chow JCL, Leung M, Fahey S (2012) Monte Carlo simulation on low-energy electrons from gold nanoparticle in radiotherapy. J Phys Conf Ser 341: 012012. doi: 10.1088/1742-6596/341/1/012012
    [25] Chow JCL, Leung M, Jaffray DA (2012) Monte Carlo simulation on gold nanoparticle irradiated by electron beams. Phys Med Biol 57: 3323–3331. doi: 10.1088/0031-9155/57/11/3323
    [26] Chauvie S, Francis Z, Guatelli S (2006) Monte Carlo simulation of interactions of radiation with biological systems at the cellular and DNA levels: The Geant4-DNA project. Rad Res 166: 652–689. doi: 10.1667/RR0683.1
    [27] Incerti S, Baldacchino G, Bernal M, et al. (2010) The Geant4-DNA. Int J Model Simul Sci Comput 1: 157–178. doi: 10.1142/S1793962310000122
    [28] Chauvie S, Francis Z, Guatelli S, et al. (2007) Geant4 physics processes for microdosimetry simulation: design foundation and implementation of the first set of models. IEEE Trans Nucl Sci 54: 2619–2628. doi: 10.1109/TNS.2007.910425
    [29] Agostinelli S, Allison J, Amako K, et al. (2003) Geant4–a simulation toolkit. Nucl Instrum Meth A 506: 250–303. doi: 10.1016/S0168-9002(03)01368-8
    [30] Karamitros M, Incerti S, Champion C (2012) The Geant4-DNA project. Rad Onc 102: S191–192. doi: 10.1016/S0167-8140(12)70325-0
    [31] Zopes D, Stein B, Mathur S, et al. (2013) Improved stability of “naked” gold nanoparticles enabled in situ coating with mono and multivalent thiol PEG ligands. Langmuir 29: 11217–11226. doi: 10.1021/la4012058
    [32] Pettibone JM, Osborn WA, Rykaczewski K, et al. (2013) Surface mediated assembly of small metastable gold nanoclusters. Nanoscale 5: 6558–6566. doi: 10.1039/c3nr01708g
    [33] Labala S, Mandapalli PK, Kurumaddali A, et al. (2015) Layer-by-layer polymer coated gold nanoparticles for topical delivery of imatinib mesylate to treat melanoma. Mol Pharm 12: 878–888. doi: 10.1021/mp5007163
    [34] Deng Y, Saucier-Sawyer JK, Holmes CJ, et al. (2014) The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles. Biomaterials 35: 6595–6602. doi: 10.1016/j.biomaterials.2014.04.038
    [35] Leung M, Chow JCL, Chithrani D, et al. (2011) Comparison of the physical characteristics of secondary electrons and dose enhancement from x-ray irradiation of gold nanoparticles using Monte Carlo simulation. Med Phys 38: 3645.
    [36] Neshatian M, Chung S, Yohan D, et al. (2015) Uptake of gold nanoparticles in breathless (hypoxic) cancer cells. J Biomed Nanotechnol 11: 1162–1172. doi: 10.1166/jbn.2015.2067
    [37] Chithrani D (2010) Intracellular uptake, transport, and processing of gold nanoparticles. Mol Membr Biol 27: 299–311. doi: 10.3109/09687688.2010.507787
    [38] Yao X, Huang C, Chen X, et al. (2015) Chemical radiosensitivity of DNA induced by gold nanoparticles. J Biomed Nanotechnol 11: 478–485. doi: 10.1166/jbn.2015.1922
    [39] Krema H, Herrmann E, Albert-Green A, et al. (2013) Orthovoltage radiotherapy in the management of medical canthal basal cell carcinoma. Br J Ophthalmol 97: 730–734. doi: 10.1136/bjophthalmol-2012-302991
    [40] Esposito E, Anninga B, Harris S, et al. (2015) Intraoperative radiotherapy in early breast cancer. Br J Surg 102: 599–610. doi: 10.1002/bjs.9781
    [41] Butterworth KT, McMahon SJ, Currell FJ, et al. (2012) Physical basis and biological mechanisms of gold nanoparticle radiosensitization. Nanoscale 4: 4830–4838. doi: 10.1039/c2nr31227a
    [42] Sultana NN, Pradhan AK, Montenegro M (2012) A new nanobiotechnological method for cancer treatment using x-ray spectroscopy of nanoparticles, In: Eom K (Ed.) Simulations in Nanobiotechnology, CRC Press, Boca Raton, 306–329.
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