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Activation of stimulus-specific processing regions at retrieval tracks the strength of relational memory

1 Department of Psychology, University of Illinois, Champaign, IL, USA
2 Beckman Institute for Advanced Science and Technology, Urbana, IL, USA
3 Department of Psychology, California State University, East Bay, Hayward, CA, USA

Many theories of episodic memory posit that the subjective experience of recollection may be driven by the activation of stimulus-specific cortical regions during memory retrieval. This study examined cortical activation during associative memory retrieval to identify brain regions that support confidence judgments of source memory in stimulus-specific ways. Adjectives were encoded with either a picture of a face or a scene. During a source memory test, the word was presented alone and the participant was asked if the word had been previously paired with a face or a scene. We identified brain regions that were selectively active when viewing pictures of scenes or faces with a separate localizer scan. We then identified brain regions that were differentially activated to words during the source memory test that had been previously paired with faces or scenes, masked by the localizer activations, and examined how those regions were modulated by the strength of the source memory. Bilateral amygdala activation tracked source memory confidence for faces, while parahippocampal cortex tracked source memory confidence for scenes. The magnitude of the activation of these domain-specific perceptual-processing brain regions during memory retrieval may contribute to the subjective strength of episodic recollection.
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Keywords relational memory; FMRI; recollection; memory strength; recapitulation

Citation: Brion Woroch, Alex Konkel, Brian D. Gonsalves. Activation of stimulus-specific processing regions at retrieval tracks the strength of relational memory. AIMS Neuroscience, 2019, 6(4): 250-265. doi: 10.3934/Neuroscience.2019.4.250


  • 1. Cohen NJ, Eichenbaum H (1993) Memory, amnesia, and the hippocampal system. Cambridge, MA, US: The MIT Press.
  • 2. Eichenbaum H, Cohen NJ (2001) From conditioning to conscious recollection: Memory systems of the brain. New York: Oxford University Press.
  • 3. Rissman J, Wagner AD (2012) Distributed representations in memory: insights from functional brain imaging. Annu Rev Psychol 63: 101–128.    
  • 4. Danker JF, Anderson JR (2010) The ghosts of brain states past: remembering reactivates the brain regions engaged during encoding. Psychol Bull 136: 87–102.    
  • 5. Rugg MD, Vilberg KL (2014) Brain Networks Underlying Episodic Memory Retrieval. Curr Opin Neurobilogy 23: 255–260.
  • 6. Morcom AM (2014) Re-engaging with the past: recapitulation of encoding operations during episodic retrieval. Front Hum Neurosci 8: 351.
  • 7. Wheeler ME, Petersen SE, Buckner RL (2000) Memory's echo: Vivid remembering reactivates sensory-specific cortex. Proc Natl Acad Sci 97: 11125–11129.    
  • 8. Johnson JD, McDuff SGR, Rugg MD, et al. (2009) Recollection, familiarity, and cortical reinstatement: a multivoxel pattern analysis. Neuron 63: 697–708.    
  • 9. Thakral PP, Wang TH, Rugg MD (2017)Decoding the content of recollection within the core recollection network and beyond. Cortex 91: 101–113.
  • 10. Johnson JD, Rugg MD (2007) Recollection and the reinstatement of encoding-related cortical activity. Cereb Cortex 17: 2507–2515.    
  • 11. Alvarez P, Squire LR (1994) Memory consolidation and the medial temporal lobe: A simple network model. Proc Natl Acad Sci U S A 91: 7041–7045.    
  • 12. McClelland JL, McNaughton BL, O'Reilly RC (1995) Why there are complementary learning systems in the hippocampus and neocortex: insights from the successes and failures of connectionist models of learning and memory. Psychol Rev 102: 419–457.    
  • 13. Moscovitch M, Rosenbaum RS, Gilboa A, et al. (2005) Functional neuroanatomy of remote episodic, semantic and spatial memory: A unified account based on multiple trace theory. J Anat 207: 35–66.    
  • 14. Norman KA, O'Reilly RC (2003) Modeling hippocampal and neocortical contributions to recognition memory: A complementary-learning-systems approach. Psychol Rev 110: 611–646.    
  • 15. Rosler F, Heil M, Hennighausen E (1995) Distinct Cortical Activation Patterns during Long-Term Memory Retrieval of Verbal , Spatial , and Color Information. J Cogn Neurosci 7: 51–65.    
  • 16. Khader P, Burke M, Bien S, et al. (2005) Content-specific activation during associative long-term memory retrieval. Neuroimage 27: 805–816.    
  • 17. Nyberg L, Habib R, Herlitz A (2000) Brain activation during episodic memory retrieval: sex differences. Acta Psychol (Amst) 105: 181–194.    
  • 18. Vaidya CJ, Zhao M, Desmond JE, et al. (2002) Evidence for cortical encoding specificity in episodic memory: memory-induced re-activation of picture processing areas. Neuropsychologia 40: 2136–2143.    
  • 19. Wheeler ME, Buckner RL (2003) Functional dissociation among components of remembering: control, perceived oldness, and content. J Neurosci 23: 3869–3880.    
  • 20. Wheeler ME, Buckner RL (2004) Functional-anatomic correlates of remembering and knowing. Neuroimage 21: 1337–1349.    
  • 21. Woodruff CC, Johnson JD, Uncapher MR, et al. (2005) Content-specificity of the neural correlates of recollection. Neuropsychologia 43: 1022–1032.    
  • 22. Liang JC, Preston AR (2017) Medial temporal lobe reinstatement of content-specific details predicts source memory. Cortex 91: 67–78.    
  • 23. Leiker EK, Johnson JD (2015) Pattern reactivation co-varies with activity in the core recollection network during source memory. Neuropsychologia 75.
  • 24. Maratos EJ, Dolan RJ, Morris JS, et al. (2001) Neural activity associated with episodic memory for emotional context. Neuropsychologia 39: 910–920.    
  • 25. Smith AP, Henson RN, Dolan RJ, et al. (2004) fMRI correlates of the episodic retrieval of emotional contexts. Neuroimage 22: 868–878.    
  • 26. Kahn I, Davachi L, Wagner AD (2004) Functional-neuroanatomic correlates of recollection: implications for models of recognition memory. J Neurosci 24: 4172–4180.    
  • 27. Voss JL, Galvan A, Gonsalves BD (2011) Neuropsychologia Cortical regions recruited for complex active-learning strategies and action planning exhibit rapid reactivation during memory retrieval. Neuropsychologia 49: 3956–3966.    
  • 28. Dodson CS, Holland PW, Shimamura AP (1998) On the recollection of specific-and partial-source information. J Exp Psychol Learn Mem Cogn 24: 1121–1136.    
  • 29. Hicks JL, Marsh RL, Ritschel L (2002) The role of recollection and partial information in source monitoring. J Exp Psychol Learn Mem Cogn 28: 503–508.    
  • 30. Simons JS, Dodson CS, Bell D, et al. (2004) Specific- and partial-source memory: effects of aging. Psychol Aging 19: 689–694.    
  • 31. Slotnick SD, Dodson CS (2005) Support for a continuous (single-process) model of recognition memory and source memory. Mem Cognit 33: 151–170.    
  • 32. Mickes L, Wais P, Wixted J (2009) Recollection is a continuous process implications for dual-process theories of recognition memory. Psychol Sci 20: 509–515.    
  • 33. Slotnick SD (2010) Remember' source memory ROCs indicate recollection is a continuous process. Memory 18: 27–39.    
  • 34. Vilberg KL, Rugg MD (2008) Memory retrieval and the parietal cortex: A review of evidence from a dual-process perspective. Neuropsychologia 46: 1787–1799.    
  • 35. Vilberg KL, Rugg MD (2009) Left parietal cortex is modulated by amount of recollected verbal information. Neuroreport 20: 1295–1299.    
  • 36. Vilberg KL, Rugg MD (2007) Dissociation of the neural correlates of recognition memory according to familiarity, recollection, and amount of recollected information. Neuropsychologia 45: 2216–2225.    
  • 37. Shimamura AP (2011) Episodic retrieval and the cortical binding of relational activity. Cogn Affect Behav Neurosci 11: 277–291.    
  • 38. Thakral PP, Wang TH, Rugg MD (2015) Cortical reinstatement and the confidence and accuracy of source memory. Neuroimage 109.
  • 39. Mack ML, Preston AR (2016) Decisions about the past are guided by reinstatement of specific memories in the hippocampus and perirhinal cortex. Neuroimage 127: 144–157.    
  • 40. Ishai A (2008) Let's face it: it's a cortical network. Neuroimage 40: 415–419.    
  • 41. Epstein R, Kanwisher N (1998) A cortical representation of the local visual environment. Nature 392: 598–601.    
  • 42. O'Craven KM, Kanwisher N (2000) Mental imagery of faces and places activates corresponding stiimulus-specific brain regions. J Cogn Neurosci 12: 1013–1023.    
  • 43. Althoff RR, Cohen NJ (1999) Eye-movement-based memory effect: A reprocessing effect in face perception. J Exp Psychol Learn Mem Cogn 25: 997–1010.    
  • 44. Walther DB, Caddigan E, Fei-Fei L, et al. (2009) Natural scene categories revealed in distributed patterns of activity in the human brain. J Neurosci 29: 10573–10581.    
  • 45. Brett M, Anton J, Valabregue R, et al. (2002) Region of interest analysis using an SPM toolbox [abstract] Presented at the 8th International Conference on Functional Mapping of the Human Brain, June 2-6, 2002, Sendai, Japan. Available on CD-ROM in NeuroImage, Vol 16.
  • 46. Warriner AB, Kuperman V, Brysbaert M (2013) Norms of valence, arousal, and dominance for 13,915 English lemmas. Behav Res Methods 45: 1191–1207.    
  • 47. Diana RA, Yonelinas AP, Ranganath C (2007) Imaging recollection and familiarity in the medial temporal lobe: A three-component model. Trends Cogn Sci 11: 379–386.    
  • 48. Gonsalves BD, Kahn I, Curran T, et al. (2005) Memory strength and repetition suppression: multimodal imaging of medial temporal cortical contributions to recognition. Neuron 47: 751–761.    
  • 49. Wais PE (2008) FMRI signals associated with memory strength in the medial temporal lobes: A meta-analysis. Neuropsychologia 46: 3185–3196.    


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