The effect of pretreatment with hydroalcoholic extract of <em>Alpinia officinarum</em> rhizome on seizure severity and memory impairment in pentylenetetrazol-induced kindling model of seizure in rat

Kamal Solati; Zahra Rabiei; Samira Asgharzade; Hossein Amini-Khoei; Ali Hassanpour; Zahra Abbasiyan; Maryam Anjomshoa; Mahmoud Rafieian-Kopaei; Kamal Solati; Zahra Rabiei; Samira Asgharzade; Hossein Amini-Khoei; Ali Hassanpour; Zahra Abbasiyan; Maryam Anjomshoa; Mahmoud Rafieian-Kopaei

doi:10.3934/Neuroscience.2019.3.128

AIMS Neuroscience

2019, Volume 6, Issue 3: 128-145. doi: 10.3934/Neuroscience.2019.3.128

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Research article

The effect of pretreatment with hydroalcoholic extract of Alpinia officinarum rhizome on seizure severity and memory impairment in pentylenetetrazol-induced kindling model of seizure in rat

1.
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
2.
Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

Received: 16 April 2019 Accepted: 15 July 2019 Published: 16 August 2019

The aim of present study is to investigate pretreatment with hydroalcoholic extract of Alpinia officinarum rhizome on the severity of epilepsy and memory impairment in rat. In this experimental study, rats were randomly assigned to seven groups. Control group and negative control group were intraperitoneally injected with normal saline and PTZ, respectively, for 10 days. The intervention groups received A. officinarum extract at different doses (50, 100 and 150 mg/kg) 30 minutes before PTZ injection. A. officinarum extract treatment in rats with PTZ-induced kindling exerted significant increase in seizure latency and significant decrease in the frequency of total body seizure, frequent spinning, and jumping. Flumazenil significantly inhibited the antiepileptic effects of A. officinarum extract in the rat receiving the extract at 150 mg/kg. A. officinarum extract can inhibit PTZ-induced seizure and memory impairment, and therefore can be considered as a potent agent which warranted further research to clarify its effects.
- Alpinia officinarum,
- seizure,
- pentylentetrazol,
- memory
Citation: Kamal Solati, Zahra Rabiei, Samira Asgharzade, Hossein Amini-Khoei, Ali Hassanpour, Zahra Abbasiyan, Maryam Anjomshoa, Mahmoud Rafieian-Kopaei. The effect of pretreatment with hydroalcoholic extract of Alpinia officinarum rhizome on seizure severity and memory impairment in pentylenetetrazol-induced kindling model of seizure in rat[J]. AIMS Neuroscience, 2019, 6(3): 128-145. doi: 10.3934/Neuroscience.2019.3.128

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Abstract

The aim of present study is to investigate pretreatment with hydroalcoholic extract of Alpinia officinarum rhizome on the severity of epilepsy and memory impairment in rat. In this experimental study, rats were randomly assigned to seven groups. Control group and negative control group were intraperitoneally injected with normal saline and PTZ, respectively, for 10 days. The intervention groups received A. officinarum extract at different doses (50, 100 and 150 mg/kg) 30 minutes before PTZ injection. A. officinarum extract treatment in rats with PTZ-induced kindling exerted significant increase in seizure latency and significant decrease in the frequency of total body seizure, frequent spinning, and jumping. Flumazenil significantly inhibited the antiepileptic effects of A. officinarum extract in the rat receiving the extract at 150 mg/kg. A. officinarum extract can inhibit PTZ-induced seizure and memory impairment, and therefore can be considered as a potent agent which warranted further research to clarify its effects.

Conflict of interest

The authors declare no conflict of interest.

References

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