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AIMS Allergy and Immunology

2018, Volume 2, Issue 3: 148-164. doi: 10.3934/Allergy.2018.3.148
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Review

Immune monitoring of the body’s borders

  • Microbiology and Immunology, Roseman University College of Medicine, 10530 Discovery Drive, USA
  • Received: 15 June 2018 Accepted: 09 August 2018 Published: 15 August 2018

  • The immune system spends most of its efforts and energy policing rather than attacking, cleaning up the molecular and cellular trash, maintaining the borders of the human body, and quashing minor disturbances rather than responding to pathogenic microbes. The cells that carry out these functions play by rules that are different from those described in the classical immunology textbooks, being triggered by alternative stimulants such as vitamin B analogues, glycolipids and cellular stress molecules and express different cell surface markers. Treg/TR1 cells and Th17 cells shift function depending upon the needs of the situation as directed by the cytokine environment. Better understanding of these “normal” functions for the immune response will also provide greater insights into dysregulation and conditions of excess as occur during autoimmune and inflammatory diseases.

    Citation: Ken S. Rosenthal. Immune monitoring of the body’s borders[J]. AIMS Allergy and Immunology, 2018, 2(3): 148-164. doi: 10.3934/Allergy.2018.3.148

    Related Papers:

  • The immune system spends most of its efforts and energy policing rather than attacking, cleaning up the molecular and cellular trash, maintaining the borders of the human body, and quashing minor disturbances rather than responding to pathogenic microbes. The cells that carry out these functions play by rules that are different from those described in the classical immunology textbooks, being triggered by alternative stimulants such as vitamin B analogues, glycolipids and cellular stress molecules and express different cell surface markers. Treg/TR1 cells and Th17 cells shift function depending upon the needs of the situation as directed by the cytokine environment. Better understanding of these “normal” functions for the immune response will also provide greater insights into dysregulation and conditions of excess as occur during autoimmune and inflammatory diseases.


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