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Protective effects of lactic acid bacteria on influenza A virus infection

Department of Probiotics Immunology, Institute for Genetic Medicine, Hokkaido University, North 15, West 7, Kita-ku, Sapporo, 0600815, Japan

Gut microbiota is essential to regulate the whole body metabolism and the immune system of the host animals. Lactic acid bacteria have as a major characteristic to produce lactic acid from glucose. As probiotics, lactic acid bacteria provide many beneficial effects on human health by regulating the gut microbiota or the cell function. Recently, we have reported that oral administration of a probiotic strain,Lactobacillus gasseri SBT2055 (LG2055) induced IgA production by increasing the population of IgA+ B cell in Peyer’s patch and propria mucosae of small intestine in mice. Furthermore, we demonstrated that oral administration of LG2055 increased the survival rate of mice infected with influenza A virus and decreased the ratio of body weight losses. The virus titer was significantly decreased and the amount of inflammatory cytokine, IL-6 in the lung tissue was reduced by LG2055 administration. The expression of antiviral genes in the lung tissues was increased by LG2055. Therefore, LG2055 administration is shown to be effective for the protection against influenza A virus infection by inhibition of viral replication through the induction of antiviral genes expression. In the future, the constituents of LG2055 to have the effects on the induction of antiviral genes should be clarified for the development of novel influenza drugs.
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References

1. Taubenberger JK, Morens DM (2010) Influenza: the once and future pandemic. Public Health Rep 125: 16–26.    

2. Medina RA, Garcíasastre A (2011) Influenza A viruses: new research developments. Nat Rev Microbiol 9: 590–603.    

3. Mazmanian SK, Round JL, Kasper DL (2008) A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 453: 620–625.    

4. Kleerebezem M, Vaughan EE (2009) Probiotic and gut lactobacilli and bifidobacteria: molecular approaches to study diversity and activity. Annu Rev Microbiol 63: 269–290.    

5. Reid G, Jass J, Sebulsky MT, et al. (2003) Potential uses of probiotics in clinical practice. Clin Microbiol Rev 16: 658–672.    

6. Olivares M, Díaz-Ropero MP, Sierra S, et al. (2007) Oral intake of Lactobacillus fermentum CECT5716 enhances the effects of influenza vaccination. Nutrition 23: 254–260.    

7. Davidson LE, Fiorino AM, Snydman DR, et al. (2011) Lactobacillus GG as an immune adjuvant for live-attenuated influenza vaccine in healthy adults: a randomized double-blind placebo-controlled trial. Eur J Clin Nutr 65: 501–507.    

8. Nakayama Y, Moriya T, Sakai F, et al. (2014) Oral administration of Lactobacillus gasseri SBT2055 is effective for preventing influenza in mice. Sci Rep 4: 4638.

9. Kadooka Y, Tominari K, Sakai F, et al. (2012) Prevention of rotavirus-induced diarrhea by preferential secretion of IgA in breast milk via maternal administration of Lactobacillus gasseri SBT2055. J Pediatr Gastr Nutr 55: 66–71.    

10. Sakai F, Hosoya T, Onoohmachi A, et al. (2014) Lactobacillus gasseri SBT2055 induces TGF-β expression in dendritic cells and activates TLR2 signal to produce IgA in the small intestine. PLoS One 9: e105370–e105370.    

11. Gill N, Wlodarska M, Finlay BB (2011) Roadblocks in the gut: barriers to enteric infection. Cell Microbiol 13: 660–669.    

12. Bosch M, Méndez M, Pérez M, et al. (2012) Lactobacillus plantarum CECT7315 and CECT7316 stimulate immunoglobulin production after influenza vaccination in elderly. Nutr Hosp 27: 504–509.

13. Maeda N, Nakamura R, Hirose Y, et al. (2009) Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice. Int Immunopharmacol 9: 1122–1125.    

14. Kechaou N, Chain F, Gratadoux JJ, et al. (2013) Identification of one novel candidate probiotic Lactobacillus plantarum strain active against influenza virus infection in mice by a large-scale screening. Appl Environ Microb 79: 1491–1499.    

15. Tetsu S, Hitoshi T, Kenta J, et al. (2015) Effects of oral intake of plasmacytoid dendritic cells-stimulative lactic acid bacterial strain on pathogenesis of influenza-like illness and immunological response to influenza virus. Brit J Nutr 114: 727–733.

16. Fukada K, Fujikura D, Nakayama Y, et al. (2013) Enterococcus faecalis FK-23 affects alveolar-capillary permeability to attenuate leukocyte influx in lung after influenza virus infection. Springerplus 2: 269.    

17. Kondoh M, Fukada K, Fujikura D, et al. (2012) Effect of water-soluble fraction from lysozyme-treated Enterococcus faecalis FK-23 on mortality caused by influenza A virus in mice. Viral Immunol 25: 86–90.

Copyright Info: © 2017, Tadaaki Miyazaki, licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution Licese (http://creativecommons.org/licenses/by/4.0)

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