Manuscript Topics

Hepatitis B virus (HBV) is a DNA virus belonging to Hepadnaviridae family of viruses. It attacks hepatocytes and causes hepatitis B which is the most common serious liver infection worldwide. This virus can cause chronic infection and puts people at high risk of death from cirrhosis and liver cancer. According to World Health Organization (WHO), an estimated 257 million people were living with chronic HBV infection and approximately 887000 deaths in 2015, mostly from cirrhosis and hepatocellular carcinoma. For these reasons, the aim of this special issue is to develop mathematical models and methods to better understand and describe the dynamics of HBV infection by taking into account some biological considerations such as the effect of immunity, different modes of transmission, vaccination and traitement. The special issue is also interested in the development of control strategies to limit the evolution and spread of the virus, whether in the human body or between humans.

Potential topics include, but are not restricted to

• Mathematical modeling and analysis of HBV infection dynamics
• Optimal control strategies for HBV infection
• Biological systems describing the dynamics of HBV infection
• Studies about the role of innate and adaptive immunity in HBV infection
• Studies about HBV and liver cancer
• Estimation of HBV parameters, sensitivity analysis and numerical simulations

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