Manuscript Topics

During the last decade, intervention in structural heart disease witnessed an impressive development. The central element of this development was represented by transcatheter aortic valve implantation (TAVI), which is now considered the standard therapy for patients at high risk for surgical aortic valve replacement (SAVR). Since the first percutaneous implantation performed by Alain Cribier in 2002, using venous access and antegrade transseptal approach, the technique has evolved enormously. Various issues, observed during the first registries and randomized trials, like vascular complications, periprosthetic aortic regurgitation, pacemaker implantation and stroke have been addressed by an improved screening process and extensive use of MSCT, miniaturisation of introducers and devices, improved device design and a modified technique. Data concerning the actual success and specificities of current TAVI valves are important for clinical decision making and evaluation of therapeutic solutions for a frail population.

This special issue focuses on the safety and outcomes of TAVI with current transcatether devices. Research concerning the procedural outcome and incidence of complications, especially aortic regurgitation, stroke, vascular complications and bleeding is within the scope of this issue. Analyses concerning all available TAVI valves are welcomed.

Results of comparisons with previous TAVI models and SAVR are encouraged. The impact of complications on hospital duration, cost and mid-term outcomes are of interest. Results in special patient populations like intermediate risk patients, the very elderly, frail patients, patients with bicuspid valves or coronary disease are relevant. Use of the VARC or VARC-2 definitions is recommended.

Keywords: TAVI; TAVR; aortic stenosis; valvular heart disease; aortic regurgitation; coronary heart disease; stroke; bicuspid aortic valve; bleeding

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