Export file:


  • RIS(for EndNote,Reference Manager,ProCite)
  • BibTex
  • Text


  • Citation Only
  • Citation and Abstract

Morphogenesis and aggressiveness of cervix carcinoma

1. Department of Physical-Chemistry, Faculty of Chemistry, University of Havana, Havana
2. Institute of Oncology and Radiobiology, Havana
3. Faculty of Physics, University of Havana, Havana

A mathematical model was obtained to describe the relation between the tissue morphology of cervix carcinoma and both dynamic processes of mitosis and apoptosis, and an expression to quantify the tumor aggressiveness, which in this context is associated with the tumor growth rate. The proposed model was applied to Stage III cervix carcinoma in vivo studies. In this study we found that the apoptosis rate was signicantly smaller in the tumor tissues and both the mitosis rate and aggressiveness index decrease with Stage III patients’ age. These quantitative results correspond to observed behavior in clinical and genetics studies.
  Article Metrics

Keywords pattern cell morphology.; Tumor growth; fractal; stochastic model; mesoscopic model

Citation: Elena Izquierdo-Kulich, Margarita Amigó de Quesada, Carlos Manuel Pérez-Amor, José Manuel Nieto-Villar. Morphogenesis and aggressiveness of cervix carcinoma. Mathematical Biosciences and Engineering, 2011, 8(4): 987-997. doi: 10.3934/mbe.2011.8.987


This article has been cited by

  • 1. Edgardo J. Suarez-Dominguez, Arthur Perez-Rivao, Maria T. Sanchez-Medrano, Josue F. Perez-Sanchez, Elena Izquierdo-Kulich, Mesoscopic model for the surface fractal dimension estimation of solid-solid and gas-solid dispersed systems, Surfaces and Interfaces, 2020, 18, 100407, 10.1016/j.surfin.2019.100407

Reader Comments

your name: *   your email: *  

Copyright Info: 2011, , licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution Licese (http://creativecommons.org/licenses/by/4.0)

Download full text in PDF

Export Citation

Copyright © AIMS Press All Rights Reserved