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Short-term outcome of laparoscopic surgery versus open surgery on colon carcinoma: A meta-analysis

Jin-Li Sun Su-Yan Xing

*Corresponding author: Su-Yan Xing xsz8859@163.com

MBE2019,5,4645doi:10.3934/mbe.2019233

Objective: The aim of this article is to compare the oncological outcomes of laparoscopic and open resection for colon cancer. Method: Search the publications on comparison the efficacy of laparoscopic surgery comparison with open surgery in treatment outcomes of colon cancer to May, 2018. After rigorous reviewing on quality, the data was extracted from eligible trials. All trials analyzed the summary hazard ratios (HRs) of the endpoints of interest, including intraoperative and postoperative outcomes. Results: A total of 13 trials were met our inclusion criteria. With the pooled result of duration of surgery indicate that laparoscopic surgery was associated with a trend longer operate time (SMD = 0.58, 95% CI 0.17–0.99; P=0.005) , shorter length of hospital stay (SMD = −0.57, 95% CI −1.00–−0.15; P = 0.008) and postoperative hospital stay (SMD = −0.66, 95% CI −0.99–−0.33; P = 0.0001) , less blood loss (SMD = −0.68, 95% CI −1.12–−0.24; P = 0.002), shorter incision length (SMD = −4.61, 95% CI −5.79–−3.43; P<=0.00001 and less wound infection (OR = 0.30, 95% CI 0.13–0.67; P = 0.004). However, there were no differences in the number of lymph nodes harvested (P = 0.17), ileus (P = 0.91), pulmonary infection (P = 0.22) and postoperative complications (P = 0.24) between the 2 groups. Conclusion: Laparoscopic surgery had similar intraoperative and postoperative recovery parameters to those of the patients in the open group. The patients treated with laparoscopic had a trend longer operate time, shorter hospital stays, less intra-operative blood loss, faster recovery and lower incidence of wound infection. Whether it can be expected to be a standardization operation method for colon carcinoma still need more random clinical trials to be verified.

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