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Parameter estimation in a structured erythropoiesis model

Azmy S. Ackleh Jeremy J. Thibodeaux

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MBE2008,4,601doi:10.3934/mbe.2008.5.601

We develop a numerical method for estimating parameters in a structured erythropoiesis model consisting of a nonlinear system of partial differential equations. Convergence theory for the computed parameters is provided. Numerical results for estimating the growth rate of precursor cells as a function of the erythropoietin concentration and the decay rate of erythropoietin as a function of the total number of precursor cells from computationally generated data are provided. Standard errors for such parameters are also given.

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Article ID   1551-0018_2008_4_601
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