Dr. Zhe Yang
Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, United States
Dr. Chunying Li
Center for Molecular and Translational Medicine, Georgia State University, Atlanta, GA 30303, United States
Introduction of the special issue
Inflammation is critical for host defense and repair of tissue injury. Inflammation contributes to many complex diseases including autoimmune disease, metabolic syndrome, neurodegenerative disorder, cancer, and cardiovascular disease. Inflammation is also associated with aging and age-related disorders. A variety of exogenous or endogenous stimuli trigger inflammation. The inflammatory response involves coordination of a multitude of cellular and molecular events. The acute and chronic inflammatory response is orchestrated by interaction of cells in the innate immune system and adaptive immune system. The subcellular organelles such as mitochondria and lysosome contribute to the inflammatory response through oxidative stress and autophagy respectively. The inflammatory response involves an intertwined intercellular and intracellular signaling network, triggering many molecular events such as transcription, translation, cytoskeletal rearrangement, and actomyosin contraction. Many molecules are involved in the inflammatory response including growth factors, cytokines, chemokines, nuclear factors, matrix metalloproteinases, and toxic molecules such as nitric oxide or free radicals. The aim of this special issue is to gather the latest information on molecular mechanisms of inflammation and discuss the imbalance in the inflammatory response and the pathological mechanisms.
Selected articles will be published in AIMS Biophysics open access free of charge. Submitted papers should not have been previously published nor be currently under consideration for publication elsewhere. All manuscripts will be peer-reviewed before their acceptance for publication.
Instruction for Authors :
Please submit your manuscript to our online submission system:
Submission due date: 15 November 2016