Cells as dynamical systems

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Guest Editors

Dr. Ulysse Herbach
Inria Nancy, Institut Élie Cartan de Lorraine

Dr. Olivier Gandrillon
CNRS, ENS de Lyon, Inria

Manuscript Topics

The goal of this special issue will be to present the state of the art in the modeling approaches of living systems, with a special focus on the cell and its intracellular regulation.
Cells are neither machines (Nicholson, 2019), nor simple information processing devices (Kupiec, 1983). Cells (like all living systems) are rooted within a physico-chemical world to which they belong. Their specific complexity nevertheless sometimes led to the idea that they should be treated differently that classical physico-chemical systems (Schrödinger, 1944).
This somehow can be seen in the separation of biology in different fields: biochemistry, molecular biology, cellular biology. We think the time has come to reunite those views. And more specifically to consider gene expression, or the formation of specific organelles as nothing more (nor less) than a biochemical process. But a biochemical process with a twist: some specificities should/could be taken into account by the modeling process including the contingent, modular, degenerated, complex, dynamical, stochastic and multi-scale nature of the living systems.

Kupiec, J.J. (1983). A probabilistic theory for cell differentiation, embryonic mortality and DNA C-value paradox. Speculations in Science and Technology 6, 471-478.
Nicholson, D.J. (2019). Is the cell really a machine? J Theor Biol 477, 108-126.
Schrödinger, E. (1944). What Is Life? The Physical Aspect of the Living Cell (Cambridge University Press).

Paper Submission
All manuscripts will be peer-reviewed before their acceptance for publication.
The deadline for manuscript submission is 24th July, 2020.

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Anissa Guillemin, Michael P. H. Stumpf
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Gerardo Aquino, Andrea Rocco
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