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The immune system through the ages

  • The components of the immune system develop in utero and like a computer, some components are immediately functional (the innate components) but other components must learn the programs and details necessary to function (antigen adaptive components). Like other systems, including military and municipal, the innate and antigen specific components develop into an immune system that helps maintain and surveil the other body processes and systems for aberrations, provide surveillance and protection of the mucoepithelial borders and protection from microbial invasion. Inability, excesses, or errors in these processes cause disease. Aging of the immune system brings immunosenescence, inflammaging, more errors, and decreased surveillance which increases risk for new infections (e.g. COVID-19, influenza), recurrence of latent infections, cancer and autoimmune and inflammatory diseases. With greater understanding of the surveillance, effector and regulatory deficits upon aging, better therapies can be developed.

    Citation: Ken S. Rosenthal, Jordan B. Baker. The immune system through the ages[J]. AIMS Allergy and Immunology, 2022, 6(3): 170-187. doi: 10.3934/Allergy.2022013

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  • The components of the immune system develop in utero and like a computer, some components are immediately functional (the innate components) but other components must learn the programs and details necessary to function (antigen adaptive components). Like other systems, including military and municipal, the innate and antigen specific components develop into an immune system that helps maintain and surveil the other body processes and systems for aberrations, provide surveillance and protection of the mucoepithelial borders and protection from microbial invasion. Inability, excesses, or errors in these processes cause disease. Aging of the immune system brings immunosenescence, inflammaging, more errors, and decreased surveillance which increases risk for new infections (e.g. COVID-19, influenza), recurrence of latent infections, cancer and autoimmune and inflammatory diseases. With greater understanding of the surveillance, effector and regulatory deficits upon aging, better therapies can be developed.



    In the study of line congruence, focal surfaces are well recognized. A focal surface is one of these line congruences, which are surfaces that are created by changing one surface to another by lines. Line congruence has been presented in the field of visualization by Pottmann et al. in [1]. They can be utilized to envision the strain and intensity circulation on a plane, temperature, precipitation, and ozone over the earth's surface, and so forth. Prior to further processing, the quality of a surface is evaluated using focal surfaces; for further information, see, for instance, [2,3,4,5]. Numerous researches have been done on focal surfaces and curves; for examples, see [6,7,8,9]. Sasai [10] described the modified orthogonal frame of a space curve in Euclidean 3-space as a helpful tool for examining analytic curves with singular points when the Frenet frame is ineffective. The modified orthogonal frame has recently been the subject of various investigations [11,12,13,14,15,16].

    The envelope of a moving sphere with variable radius is characterized as a canal surface, which is frequently used in solid and surface modeling. A canal surface is an envelope of a one-parameter set of spheres centered at the center curve c(s) with radius r(s). The spheres that are specified by r(s) and c(s) are combined to form a canal surface, which is obtained by the spine curve. These surfaces have a wide range of uses, including form reconstruction, robot movement planning, the creation of blending surfaces, and the easy sight of long and thin objects like pipes, ropes, poles, and live intestines. The term "tubular surface" refers to these canal surfaces if r(s) is constant. Different frames have been used to study tubular surfaces; for more details, see [17,18,19,20,21,22,23]. The paper is organized as follows: The fundamental ideas and the modified orthogonal frame are presented in Section 2. In Section 3, we create tubular surfaces with a modified orthogonal frame and provide some findings from these surfaces. Section 4 provides the focal surfaces of tubular surfaces in accordance with the modified orthogonal frame in E3. At last, an example that confirms our findings is presented in Section 5.

    Let α=α(s) be a space curve with respect to the arc-length s in E3 and t,n,b be the tangent, principal, and binormal unit vectors at each point on α(s), respectively, then we have the Serret-Frenet equations:

    [t(s)n(s)b(s)]=[0κ0κ0τ0τ0][t(s)n(s)b(s)], (2.1)

    where κ and τ are, respectively, the curvature and torsion functions of α.

    Since, the Serret-Frenet frame is inadequate for studying analytic space curves, of which curvatures have discrete zero points since the principal normal and binormal vectors may be discontinuous at zero points of the curvature, Sasai presented an orthogonal frame and obtained a formula, which corresponds to the Frenet-Serret equation [10].

    Let α:IE3 be an analytic curve. We suppose that the curvature κ(s) of α is not identically zero. We express an orthogonal frame {T,N,B} as

    T=dαds,N=dTds, B=T×N. (2.2)

    The relations between the frames {T,N,B} and {t,n,b} at nonzero points of κ are expressed as follows:

    T=t,N=κn,B=κb, (2.3)

    and we have

    T,T=1,N,N=B,B=κ2,T,N=T,B=N,B=0. (2.4)

    From Eqs (2.1) and (2.3), a straightforward calculation leads to

    [T(s)N(s)B(s)]=[010κ2κκτ0τκκ][T(s)N(s)B(s)], (2.5)

    and

    τ(s)=det(α,α,α)κ2,

    is the torsion of α. Therefore, the frame denoted by Eq (2.5) is called the modified orthogonal frame.

    Let Υ(s,θ) be a surface in E3 and U(s,θ) be the unit normal vector field on Υ(s,θ) defined by U=Υs×ΥθΥs×Υθ, where Υs=Υs and Υθ=Υθ are the tangent vectors of Υ(s,θ). The metric (first fundamental form) I of Υ(s,θ) is defined by

    I=g11ds2+2g12dsdθ+g22dθ2,

    where g11=Υs,Υs, g12=Υs,Υθ, and g22=Υθ,Υθ.

    Also, we can define the second fundamental form of Υ(s,θ) as

    II=h11ds2+2h12dsdθ+h22dθ2,

    where h11=Υss,U, h12=Υsθ,U, h22=Υθθ,U, and U is the unit normal vector of the surface. The Gaussian curvature K and the mean curvature H are, respectively, expressed as:

    K=h11h22h212g11g22g212,H=h11g222g12h12+g11h222(g11g22g212). (2.6)

    In this part, we obtain a tubular surface with modified orthogonal frame and give some important properties of this surface in E3. The tubular surface with respect to the modified orthogonal frame has the parametrization:

    Υ(s,θ)=c(s)+rκ(s)(cosθN(s)+sinθB(s)), (3.1)

    where c(s) is the center curve, r=constant, and κ0. The derivatives of Υ(s,θ) are given by

    Υs=(1rκcosθ)T+τrκ(sinθN+cosθB),Υθ=rκ(sinθN+cosθB),Υss=(rκcosθ+rκτsinθ)T+(1rκcosθrκτsinθrκτ2cosθ)N+(rκτcosθrκτ2sinθ)B,Υsθ=(rκsinθ)T+τrκ(cosθNsinθB),Υθθ=rκ(cosθNsinθB). (3.2)

    Therefore, we obtain

    g11=(1rκcosθ)2+r2τ2,g12=τr2,g22=r2,g=g11g22g212=r2(1rκcosθ)20. (3.3)

    The unit normal vector field U is given by

    U(s)=1κcosθN1κsinθB, (3.4)

    and we have

    h11=κcosθ(1rκcosθ)+τ2r,h12=τr,h22=r. (3.5)

    From Eq (2.6), we find

    K=κcosθr(1rκcosθ),H=12rκcosθ2r(1rκcosθ). (3.6)

    From Eqs (3.1) and (3.6), we note that, if the Gaussian curvature K is zero, then the tubular surface is generated by a moving sphere with the radius r=1, [18].

    Also, the curvatures of the tubular surface Υ(s,θ) satisfy the relation:

    H=12(Kr+1r), (3.7)

    and the shape operator of Υ(s,θ) is given by

    S=1g[h11g22h12g12h12g22h22g12h11g12+h12g11h12g12+h22g11]=1r2(1rκcosθ)2[r2(κcosθ(1rκcosθ))0τr(1rκcosθ)r(1rκcosθ)2]. (3.8)

    It follows that the principal curvatures of Υ(s,θ) are obtained as:

    k1=1r,k2=κcosθ1rκcosθ=Kr. (3.9)

    Proposition 3.1. Let Υ(s,θ) be a tubular surface in E3, then Υ(s,θ) is not a flat surface.

    Proof. The proof can be obtained by straightforward calculations from Eq (3.6).

    Proposition 3.2. Let Υ(s,θ) be a tubular surface in E3, then Υ(s,θ) is minimal if and only if

    r=12κcosθ.

    Proof. The result is obtained directly from Eq (3.6).

    Theorem 3.1. Let Υ(s,θ) be a tubular surface in E3 with a modified orthogonal frame, then

    (i) the s-curves of Υ(s,θ) are asymptotic curves if and only if

    r=κcosθκ2cosθ2+τ2,

    (ii) the θ-curves of Υ(s,θ) cannot be asymptotic curves.

    Proof. From the definition of asymptotic curves, we obtain

    Υss,U=0,Υθθ,U=0.

    ⅰ. From Eq (3.5), we can get

    h11=κcosθ(1rκcosθ)+τ2r=0,r=κcosθκ2cosθ2+τ2.

    ⅱ. Υ(s,θ) is regular if h220. Thus, the s-curves of Υ(s,θ) cannot be asymptotic curves.

    Theorem 3.2. Let Υ(s,θ) be a tubular surface in E3 with a modified orthogonal frame, then

    i. s-curves of Υ(s,θ) are geodesic if and only if,

    rκ2cos2θ2κcosθ+τ2r=c,

    where c is a constant.

    ii. θ-curves of  Υ(s,θ) are geodesic.

    Proof. From the definition of geodesic curves, we find that, Υss×U=0 and Υθθ×U=0.

    ⅰ. According to Eqs (3.2) and (3.4), we obtain

    Υss×U=(κsinθ(rκcosθ1)+rτ)T+(rκsinθ(τκsinθκcosθ))N+(rκcosθ(τκsinθ+κcosθ))B.

    Since T,N, and B are linearly independent, then Υss×U=0 if and only if

    κsinθ(rκcosθ1)+rτ=0,rκsinθ(τκsinθκcosθ)=0,rκcosθ(τκsinθκcosθ)=0.

    When the last two equations are taken into consideration together and the necessary operations are done, we get

    rκκcos2θκcosθ+rττ=0,rκ2cos2θ2κcosθ+τ2r=c,

    where c is constant.

    ⅱ. Also, from Eqs (3.2) and (3.4), we have Υθθ×U=0. Thus, θ- parameter curves are geodesic curves.

    Definition 3.1. The pair (X,Y),XY of the curvatures K,H of a tubular surface Υ(s,θ) is said to be a (X,Y)-Weingarten surface if Φ(X,Y)=0, where the Jacobi function Φ is defined as XsYθYsXθ=0 [24].

    Definition 3.2. The pair (X,Y),XY of the curvatures K,H of the tubular surface Υ(s,θ) is said to be a (X,Y)-linear Weingarten surface if Υ(s,θ) satisfies the following relation:

    aX+bY=c,

    where (a,b,c)ϵR and (a,b,c)(0,0,0) [25].

    Now, we define the partial derivatives of the curvatures of Υ(s,θ):

    Ks=κcosθr(1rκcosθ)2,Kθ=κsinθr(1rκcosθ)2,Hs=r2(κcosθr(1rκcosθ)2),Hθ=r2(κsinθr(1rκcosθ)2). (3.10)

    Proposition 3.3. Let Υ(s,θ) be a tubular surface in E3 with a modified orthogonal frame, then Υ(s,θ) is a Weingarten surface.

    Proof. (K,H)-Weingarten surface Υ(s,θ) satisfies Jacobi equation:

    HsKθHθKs=0,
    HsKθ=HθKs.

    Thus, the conclusion follows from Eq (3.10).

    Proposition 3.4. Let Υ(s,θ) be a tubular surface in E3 with a modified orthogonal frame. If (K,H) is a linear Weingarten surface, then for c=1, the relations a=r2 and b=2r, hold.

    Proof. The (K,H)-linear Weingarten surface satisfies:

    aK+bH=1,

    where a,bR and (a,b)0. From Eq (3.7), we get

    2rb=(κcosθr(1rκcosθ))(br+2a),

    and

    2κcosθ(r2+rb+a)+2rb=0,

    so we find,

    2rb=0,2κcosθ(r2+rb+a)=0,

    since b=2r; therefore, a=r2 is obtained.

    Let Υ(s,θ) be a surface in E3 parameterized by

    C(s,θ,z)=Υ(s,θ)+zE(s,θ), (4.1)

    where E(s,θ) is the set of all unit vectors and z is a marked distance. For each (s,θ), Eq (4.1) indicates a line congruence and called a generatrix. Additionally, there exist two special points (real, imaginary, or unit) on the generatrix of C. These points are called focal points, which are the osculating points with generatrix. Hence, focal surfaces are defined as a geometric locus of focal points. If E(s,θ)=U(s,θ), then C=Cu is a normal congruence. The parametric equation of focal surfaces of Cu is given as

    Υi(s,θ)=Υ(s,θ)+1kiU(s,θ);i=1,2, (4.2)

    where k1 and k2 are the principle curvature functions of surfaces Υ(s,θ)[1].

    In this section, we get focal surfaces of a tubular surface with the modified orthogonal frame in E3. Also, we investigate the properties obtained for the tubular surface within the focal surfaces. Since k1=1r, the focal surface is the curve c(s). Hence, we obtain the focal surface Υ(s,θ) of Υ(s,θ) with the function k2=κcosθ1rκcosθ, as follows:

    Υ(s,θ)=c(s)+1κcosθ(1κcosθN+1κsinθ B), (4.3)

    where κ0.

    The derivatives of Υ(s,θ) are

    Υs=1κ2(κκτtanθ)N+1κ2(τκκtanθ)B,Υθ=1κ2sec2θB,Υss=(κκ+τtanθ)T+(2κ2κ4+2κτtanθκ3κκ3τκ2tanθτ2κ2)N+(2κτκ3+2κ2tanθκ4+τκ2τ2κ2tanθκκ3tanθ)B,Υθθ=2κ2sec2θtanθ B. (4.4)

    From Eq (4.4), we get

    g11=1κ2sec2θ(τ2+κ2κ2),g12=1κ2sec2θ(τκκtanθ),g22=1κ2sec4θ,g=g11g22g212=1κ4sec4θ(τtanθ+κκ)20, (4.5)

    and

    Υs×Υθ=(1κ4sec2θ(κκ+τtanθ))T,Υs×Υθ=1κ4sec2θ(κκ+τtanθ),U(s,θ)=T. (4.6)

    From Eqs (4.4) and (4.6), we obtain

    h11=(κκτtanθ),h12=0,h22=0. (4.7)

    Also, from Eqs (4.5) and (4.7), we get

    K=0,H=κ32(κτtanθ+κ). (4.8)

    Further, the shape operator of the surface Υ(s,θ) is expressed as

    S=1γ[1κ2sec4θ(κκ+τtanθ)01κ2sec2θ(τκκtanθ)(κκ+τtanθ)0], (4.9)

    where, γ=1κ4sec4θ(τtanθ+κκ)2.

    Proposition 4.1. Let Υ(s,θ) be a tubular surface in E3 with a modified orthogonal frame obtained with the parametrization given by Eq (3.1) and let Υ(s,θ) be its focal surface with the parametrization given by Eq (4.3), then the focal surface Υ(s,θ) is a flat surface.

    Proof. The proof can be obtained by using Eq (4.8) and straightforward calculations.

    Proposition 4.2. Let Υ(s,θ) be a tubular surface in E3 with a modified orthogonal frame obtained with the parametrization given by Eq (3.1) and let Υ(s,θ) be its focal surface with the parametrization given by Eq (4.3), then the focal surface Υ(s,θ) is not minimal surface.

    Proof. From Eq (4.8), we get

    κ32(κτtanθ+κ)0.

    So, Υ(s,θ) is not minimal.

    Theorem 4.1. Let Υ(s,θ) be a tubular surface in E3 with a modified orthogonal frame obtained with the parametrization given by Eq (3.1) and let Υ(s,θ) be its focal surface with the parametrization given by Eq (4.3), then

    (i) s-curves of Υ(s,θ) cannot be asymptotic curves.

    (ii) θ-curves of Υ(s,θ) are asymptotic curves.

    Proof. (ⅰ) From Eq (4.7), we get

    h11=Υss,U,=(κκτtanθ)0.

    Since Υ(s,θ) is regular; h110. Thus, s-parameter curves of the focal surface Υ(s,θ) cannot be asymptotic curves.

    (ⅱ) Also, from Eq (4.7), we get

    h22=Υθθ,U=0.

    Since h22=0, then θ-curves of Υ(s,θ) are asymptotic curves.

    Theorem 4.2. Let Υ(s,θ) be a tubular surface in E3 with a modified orthogonal frame obtained with the parametrization given by Eq (3.1) and let Υ(s,θ) be its focal surface with the parametrization given by Eq (4.3), then

    (i) s-parameter curves of  Υ(s,θ) are geodesic curves if and only if,

    2κκ=ττ.

    (ii) θ-parameter curves of Υ(s,θ) are not geodesic curves.

    Proof. (ⅰ) From Eqs (4.4) and (4.6), we have

    Υss×U=(2κ2τκ3+2κ2tanθκ4+τκ2τ2tanθκ2κtanθκ3)N+(2κκ4+2κτtanθκ3τtanθκ2κκ3τ2κ2)B.

    Therefore, Υss×U=0 if and only if

    2κκ=ττ.

    (ⅱ) From Eqs (4.4) and (4.6), we get

    Υθθ×U=2sec2θtanθκ2N.

    Since Υθθ×U0, then θ-parameter curves are not geodesic curves of Υ(s,θ).

    Hence, the proof is completed.

    The partial derivatives of the curvatures of Υ(s,θ) are

    Ks=0, Kθ=0,Hs=3κ2κ2(κτtanθ+κ)+κ3(τκtanθ+κτtanθ+κ)2(κτtanθ+κ)2,Hθ=κ4τsec2θ2(κτtanθ+κ)2. (4.10)

    Thus, we get the result:

    Proposition 4.3. Let Υ(s,θ) be a tubular surface in E3 with a modified orthogonal frame obtained with the parametrization given by Eq (3.1) and let Υ(s,θ) be its focal surface with the parametrization given by Eq (4.3), then the focal surface Υ(s,θ) is a Weingarten surface but not a linear-Weingarten surface.

    Proof. The conclusion can be obtained easily from Eqs (4.8) and (4.10).

    Definition 4.1. [8] A surface Υ(s,θ) in E3 with principal curvatures k1k2 has a generalized focal surface ˜Υ(s,θ) given by

    ˜Υ(s,θ)=Υ(s,θ)+f(k1,k2)U(s,θ),

    where f(k1,k2) is related to its principal curvatures.

    If

    f(k1,k2)=k21+k22k1+k2,

    then ˜Υ(s,θ) is expressed as

    ˜Υ(s,θ)=Υ(s,θ)+(k21+k22k1+k2)U(s,θ).

    Therefore, by employing this definition and using Eq (3.9), we can obtain a generalized focal surface ˜Υ(s,θ) of Υ(s,θ) as

    ˜Υ(s,θ)=c(s)+1κ(rK2r4+1Kr3+r)(cosθN+sinθB).

    Let us demonstrate the above considerations in a computational example. So, assume the center curve α is given by

    α(s)=(cos(53s),sin(53s),2s3),

    then, its modified orthogonal frame is calculated as follows:

    T=(53sin(53s),53cos(53s),23),N=(59cos(53s),59sin(53s),0),B=(1027sin(53s),1027cos(53s),5527).

    When the radius function r(s)=1, we obtain the tubular surface:

    Υ(s,θ)=(cos(53s)cosθcos(53s)+23sinθsin(53s),sin(53s)cosθsin(53s)23sinθcos(53s),2s3+53sinθ).)

    In addition, we get the focal surface of Υ(s,θ) as

    Υ(s,θ)=(cos(53s)95cos(53s)+65tanθsin(53s),sin(53s)95sin(53s)65tanθcos(53s),2s3+353tanθ).)

    The center curve α(s) and the corresponding tubular surface Υ(s,θ) are shown in Figures 1a and 1b, respectively.

    Figure 1.  (a) The center curve α(s); (b) the tubular surface Υ(s,θ).

    Also, the generalized focal surface of Υ(s,θ) is obtained as follows:

    ˜Υ(s,θ)=(cos(53s)ρcos(53s)cosθ+23ρsinθsin(53s),sin(53s)ρsin(53s)cosθρ23sinθcos(53s),2s3+ρ53sinθ.);
    ρ=(1(59cosθ159cosθ)2+1(59cosθ159cosθ)+1).

    The focal surface Υ(s,θ) is displayed in Figure 2a and the generalized focal surface ˜Υ(s,θ) is displayed in Figure 2b.

    Figure 2.  (a) The focal surface Υ(s,θ) with r(s)=1; (b) the generalized focal surface ˜Υ(s,θ).

    Finally, in the light of aforementioned calculations, we can conclude the above results as follows:

    ● While Υ(s,θ) is a not flat surface, the focal surface Υ(s,θ) is flat.

    Υ(s,θ) is a minimal surface, but the focal surface Υ(s,θ) is not minimal.

    ● The s-parameter curves of Υ(s,θ) are asymptotic, while the s-parameter curves of the Υ(s,θ) are non-asymptotic.

    ● The θ-parameter curves of the tubular surface  Υ(s,θ) are not asymptotic, but the θ-parameter curves of the focal surface Υ(s,θ) are asymptotic.

    ● The s and θ parameters of the tubular surface  Υ(s,θ) are geodesic curves, but the s parameter curve of Υ(s,θ) is a geodesic whereas the θ parameter curve is not a geodesic curve.

    Υ(s,θ) and focal surface Υ(s,θ) are Weingarten surfaces.

    Υ(s,θ) can be a linear Weingarten surface while the focal surface Υ(s,θ) is not a linear Weingarten surface.

    In this paper, tubular surfaces and their focal surfaces have been studied in E3. Some characteristics of the tubular surfaces have been presented such as minimal, Weingarten, linear-Weingarten, and flat. Afterward, focal surfaces of tubular surfaces have been obtained with modified orthogonal frame. Similar properties have been investigated for focal surfaces, that is, it has been shown that the focal surfaces are flat, Weingarten, and linear Weingarten, but they are not minimal surfaces. In addition, asymptotic and geodesic curves of the tubular and focal surfaces have been investigated. Finally, to confirm our results, a computational example is given and plotted.

    The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.

    The authors want to thank the referees for their important remarks and ideas which assisted with working on this paper. Additionally, the first author wants to thank the Islamic University of Madinah.

    The authors declare that there are no conflicts of interest.



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