Search Advanced

Mathematical Biosciences and Engineering

2013, Volume 10, Issue 3: 609-624. doi: 10.3934/mbe.2013.10.609
Previous Article Next Article

Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha?

  • 1.
    MBI, Ohio State University, Columbus, OH 43210
  • 2.
    Department of Mathematics, University of Botswana, Gaborone
  • Received: 01 July 2012 Accepted: 29 June 2018 Published: 01 April 2013

  • MSC : 92D30.

  • We consider a model incorporating the influence of innate and adaptive immune responses on malaria pathogenesis. By calculating the model reproduction number for a special representation of cytokine interaction, we have shown that the cytokine tumour necrosis factor-$\alpha$ can be administered to inhibit malaria infection. We have also found that if the cytokine $F^*$ and a generic drug of efficacy $\epsilon$ are administered as dual therapy then clearance of the parasite can be achieved even for a generic drug of low efficacy. Our study is recommending administration of dual therapy as a strategy to prevent parasites from developing resistance to malaria treatment drugs.

    Citation: Avner Friedman, Edward M. Lungu. Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha?[J]. Mathematical Biosciences and Engineering, 2013, 10(3): 609-624. doi: 10.3934/mbe.2013.10.609

    Related Papers:

    [1] Lingli Zhou, Fengqing Fu, Yao Wang, Ling Yang . Interlocked feedback loops balance the adaptive immune response. Mathematical Biosciences and Engineering, 2022, 19(4): 4084-4100. doi: 10.3934/mbe.2022188
    [2] Donggu Lee, Sunju Oh, Sean Lawler, Yangjin Kim . Bistable dynamics of TAN-NK cells in tumor growth and control of radiotherapy-induced neutropenia in lung cancer treatment. Mathematical Biosciences and Engineering, 2025, 22(4): 744-809. doi: 10.3934/mbe.2025028
    [3] Eduardo Ibargüen-Mondragón, M. Victoria Otero-Espinar, Miller Cerón Gómez . A within-host model on the interaction dynamics between innate immune cells and Mycobacterium tuberculosis. Mathematical Biosciences and Engineering, 2025, 22(3): 511-527. doi: 10.3934/mbe.2025019
    [4] Simeone Marino, Edoardo Beretta, Denise E. Kirschner . The role of delays in innate and adaptive immunity to intracellular bacterial infection. Mathematical Biosciences and Engineering, 2007, 4(2): 261-286. doi: 10.3934/mbe.2007.4.261
    [5] A. D. Al Agha, A. M. Elaiw . Global dynamics of SARS-CoV-2/malaria model with antibody immune response. Mathematical Biosciences and Engineering, 2022, 19(8): 8380-8410. doi: 10.3934/mbe.2022390
    [6] Ephraim O. Agyingi, Tamas I. Wiandt, Laurence U. Buxbaum, Bolaji N. Thomas . Modeling the immune system response: an application to leishmaniasis. Mathematical Biosciences and Engineering, 2020, 17(2): 1253-1271. doi: 10.3934/mbe.2020064
    [7] Prathibha Ambegoda, Hsiu-Chuan Wei, Sophia R-J Jang . The role of immune cells in resistance to oncolytic viral therapy. Mathematical Biosciences and Engineering, 2024, 21(5): 5900-5946. doi: 10.3934/mbe.2024261
    [8] Tianqi Song, Chuncheng Wang, Boping Tian . Mathematical models for within-host competition of malaria parasites. Mathematical Biosciences and Engineering, 2019, 16(6): 6623-6653. doi: 10.3934/mbe.2019330
    [9] Denise E. Kirschner, Alexei Tsygvintsev . On the global dynamics of a model for tumor immunotherapy. Mathematical Biosciences and Engineering, 2009, 6(3): 573-583. doi: 10.3934/mbe.2009.6.573
    [10] Farzad Fatehi, Yuliya N. Kyrychko, Konstantin B. Blyuss . Time-delayed model of autoimmune dynamics. Mathematical Biosciences and Engineering, 2019, 16(5): 5613-5639. doi: 10.3934/mbe.2019279
  • We consider a model incorporating the influence of innate and adaptive immune responses on malaria pathogenesis. By calculating the model reproduction number for a special representation of cytokine interaction, we have shown that the cytokine tumour necrosis factor-$\alpha$ can be administered to inhibit malaria infection. We have also found that if the cytokine $F^*$ and a generic drug of efficacy $\epsilon$ are administered as dual therapy then clearance of the parasite can be achieved even for a generic drug of low efficacy. Our study is recommending administration of dual therapy as a strategy to prevent parasites from developing resistance to malaria treatment drugs.


    [1] Parasitology, 99 (Suppl) (1989), S59-S79.
    [2] Math. Model. Nat. Pheno, 3 (2008), 229-266.
    [3] 169 (2002), 2956-2963.
    [4] Clinical and Experimental Immunology, 133 (2003), 145-152.
    [5] Mathematical Biosciences, 165 (2000), 27-39.
    [6] PNAS, 106 (2009), 11246-11251.
    [7] Immunol. Cells Biology, 78 (2000), 318-324.
    [8] J. Infect. Dis, 185 (2002), 971.
    [9] Current Opinion in Immunology, 17 (2005), 381-387.
    [10] Parasite Immunol, 19 (1997), 375.
    [11] Eeperimental Gerontology, 43 (2008), 275-285.
    [12] Parasitology, 110 (1995), 115-122.
    [13] Parasitology, 121 (2000), 227-235.
    [14] Journal of Theoretical Biology and Medical Modeling, 5 (2008), 4.
    [15] Parasitology, 113 (1996), 25-38.
    [16] Infect. Immun, 64 (1996), 535.
    [17] Infect. Immun, 64 (1996), 44.
    [18] Notices of the AMS, 43 (1996), 91-202.
    [19] Proc. Natl. Acad. Sci. USA, 101 (2004), 9161-9166.
    [20] Am. J. Trop. Med. Hyg., 71 (2004), 64-70.
    [21] Cellular Microbiology, 10 (2008), 1947-1955.
    [22] Ph.D thesis, Stellenbosch University, RSA. 2012.
    [23] Ecol. Lett., 6 (2003), 866-880.
    [24] Infect. Genet. Evol., 7 (2007), 577-586.
    [25] WHO. 2008, http://www.rollbackmalaria.org.
    [26] Infect. Immun., 59 (1991), 3280-3283.
    [27] The Journal of Immunology, 155 (1995), 2545-2556.
    [28] J. Immunol., 143 (1989), 2038.
    [29] Infect. Immun., 65 (1997), 1593.
    [30] Am. J. Trop. Med. Hyg., 71 (2004), 16-24.
    [31] Resent Patents on Anti-infective Drug Discovery, 3 (2008), 168-176.
    [32] Mathematical Bioscinces, 180 (2002), 29-48.
  • Reader Comments
  • © 2013 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Mathematical Biosciences and Engineering
4.4

Metrics

Article views(3006) PDF downloads(512) Cited by(0)

Preview PDF
Download XML
Export Citation
Article outline
Abstract
References

Other Articles By Authors

Related pages

Tools

Copyright © AIMS Press

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return

Catalog