It is widely acknowledged that an imbalanced biomechanical environment can have significant effects on myocardial pathology, leading to adverse remodelling of cardiac function if it persists. Accurate stress prediction essentially depends on the strain energy function which should have competent descriptive and predictive capabilities. Previous studies have focused on myofibre dispersion, but not on fibres along other directions. In this study, we will investigate how fibre dispersion affects myocardial biomechanical behaviours by taking into account both the myofibre dispersion and the sheet fibre dispersion, with a focus on the sheet fibre dispersion. Fibre dispersion is incorporated into a widely-used myocardial strain energy function using the discrete fibre bundle approach. We first study how different dispersion affects the descriptive capability of the strain energy function when fitting to ex vivo experimental data, and then the predictive capability in a human left ventricle during diastole. Our results show that the chosen strain energy function can achieve the best goodness-of-fit to the experimental data by including both fibre dispersion. Furthermore, noticeable differences in stress can be found in the LV model. Our results may suggest that it is necessary to include both dispersion for myofibres and the sheet fibres for the improved descriptive capability to the ex vivo experimental data and potentially more accurate stress prediction in cardiac mechanics.
Citation: Debao Guan, Yuqian Mei, Lijian Xu, Li Cai, Xiaoyu Luo, Hao Gao. Effects of dispersed fibres in myocardial mechanics, Part I: passive response[J]. Mathematical Biosciences and Engineering, 2022, 19(4): 3972-3993. doi: 10.3934/mbe.2022183
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It is widely acknowledged that an imbalanced biomechanical environment can have significant effects on myocardial pathology, leading to adverse remodelling of cardiac function if it persists. Accurate stress prediction essentially depends on the strain energy function which should have competent descriptive and predictive capabilities. Previous studies have focused on myofibre dispersion, but not on fibres along other directions. In this study, we will investigate how fibre dispersion affects myocardial biomechanical behaviours by taking into account both the myofibre dispersion and the sheet fibre dispersion, with a focus on the sheet fibre dispersion. Fibre dispersion is incorporated into a widely-used myocardial strain energy function using the discrete fibre bundle approach. We first study how different dispersion affects the descriptive capability of the strain energy function when fitting to ex vivo experimental data, and then the predictive capability in a human left ventricle during diastole. Our results show that the chosen strain energy function can achieve the best goodness-of-fit to the experimental data by including both fibre dispersion. Furthermore, noticeable differences in stress can be found in the LV model. Our results may suggest that it is necessary to include both dispersion for myofibres and the sheet fibres for the improved descriptive capability to the ex vivo experimental data and potentially more accurate stress prediction in cardiac mechanics.
Let
12, 22, …, (p−12)2 |
are pairwise incongruent modulo
Let
∏1≤j<k≤(p−1)/2(ζaj2−ζak2)={±i(p−1)/4p(p−3)/8ε(ap)h(p)/2p if p≡1 (mod 4),(−p)(p−3)/8 if p≡3 (mod 8),(−1)(p+1)/8+(h(−p)−1)/2(ap)p(p−3)/8i if p≡7 (mod 8), |
where
(−1)ap+12⌊p−14⌋2(p−1)(p−3)/8∏1≤j<k≤(p−1)/2cosπa(k2−j2)p=∏1≤j<k≤(p−1)/2(ζaj2+ζak2)={1if p≡3 (mod 4),±ε(ap)h(p)((2p)−1)/2pif p≡1 (mod 4). | (1.1) |
Our first theorem confirms [7,Conjecture 6.7].
Theorem 1.1. Let
∏1≤j<k≤(p−1)/2(ζaj2+ζak2)=(−1)|{1≤k<p4: (kp)=−1}|. | (1.2) |
(−1)|{1≤k<p4: (kp)=−1}|∏1≤j<k≤(p−1)/2(ζaj2+ζak2)=(ap)ε−(ap)h(p)p. | (1.3) |
Remark 1.1. Let
|{1≤k<p4: (kp)=1}|≡0 (mod 2)⟺y≡(2p)−1 (mod 8). |
Thus
(−1)|{1≤k<p4: (kp)=−1}|=(−1)p−14(−1)14(y−(2p)+1)=(−1)⌊y4⌋. | (1.4) |
Let
s(p):=|{(j,k): 1≤j<k≤p−12 {j2}p>{k2}p}| |
and
t(p):=|{(j,k): 1≤j<k≤p−12 {k2−j2}p>p2}| |
as in [7], where
(−1)s(p)=(−1)t(p)={1if p≡3 (mod 8),(−1)(h(−p)+1)/2if p≡7 (mod 8). |
He also conjectured that (cf. [7,Conjecture 6.1]) if
s(p)+t(p)≡|{1≤k<p4: (kp)=1}| (mod 2). | (1.5) |
Our second theorem in the case
Theorem 1.2. Let
|{(j,k): 1≤j<k≤p−12 {aj2}p>{ak2}p}|+|{(j,k): 1≤j<k≤p−12 {ak2−aj2}p>p2}|≡|{1≤k<p4: (kp)=(ap)}| (mod 2). | (1.6) |
Our third theorem was first conjectured by Sun (cf. [7,Conjectures 6.3 and 6.4]).
Theorem 1.3. Let
(−1)|{(j,k): 1≤j<k≤(p−1)/2 and {j(j+1)}p>{k(k+1)}p}|=(−1)⌊(p+1)/8⌋. | (1.7) |
(−1)|{(j,k): 1≤j<k≤(p−1)/2 {Tj}p>{Tk}p}|=(−1)h(−p)+12+|{1≤k≤⌊p+18⌋: (kp)=1}|. | (1.8) |
We will prove Theorems 1.1-1.2 in Section 2. Based on an auxiliary theorem given in Section 3, we are going to prove Theorem 1.3 in Section 4.
In 2006, H. Pan [6] obtained the following lemma.
Lemma 2.1. (H. Pan [6]) Let
sign(πc)=(cn)(n+1)/2, |
where
Proof of the First Part of Theorem 1.1. As
∏1≤j<k≤(p−1)/2ζ2aj2−ζ2ak2ζaj2−ζak2=∏1≤j<k≤(p−1)/2ζaπc(j)2−ζaπc(k)2ζaj2−ζak2=(−1)|{(j,k): 1≤j<k≤(p−1)/2 πc(j)>πc(k)}|=sign(πc)=(cp) |
with the aid of Lemma 2.1. In view of K. S. Williams and J. D. Currie [8,(1.4)], we have
(cp)≡c(p−1)/2=(c2)(p−1)/4≡2(p−1)/4≡(−1)|{0<k<p4: (kp)=−1}| (mod p). |
Therefore (1.2) holds in the case
Remark 2.1. Our method to prove part (ⅰ) of Theorem 1.1 does not work for part (ⅱ) of Theorem 1.1.
Proof of the Second Part of Theorem 1.1. We distinguish two cases.
Case 1.
In this case,
{{aj2}p: 1≤j≤p−12}={{k2}p: 1≤k≤p−12} |
So it suffices to show (1.3) for
(−1)|{0<k<p4: (kp)=−1}|∏1≤j<k≤(p−1)/2(ζj2+ζk2)>0. | (2.1) |
As
(ζj2+ζk2)(ζj2∗+ζk2∗)=(ζj2+ζk2)(ζ−j2+ζ−k2)=|ζj2+ζk2|2>0; |
also,
{j,k}={j∗,k∗}⟺j∗=k and k∗=j⟺j∗=k. |
For
ζj2+ζj2∗=ζj2+ζ−j2=2cos2πj2p=2cos2πj2∗p |
and hence
ζj2+ζj2∗>0⟺cos2πj2p>0⟺{j2}p<p4 or {j2∗}p<p4. |
Thus the sign of the product
∏1≤j<k≤(p−1)/2p∣j2+k2(ζj2+ζk2)=(−1)(p−1)/4∏1≤j<j∗≤(p−1)/2(−ζj2−ζj2∗) |
is
(−1)(p−1)/4−|{1≤k<p4: (kp)=1}|=(−1)|{1≤k<p4: (kp)=−1}|. |
So (2.1) holds and (1.3) follows.
Case 2.
By the discussion in Case 1, we have
(−1)|{0<k<p4: (kp)=−1}|∏1≤j<k≤(p−1)/2(ζj2+ζk2)=ε−h(p)p. | (2.2) |
Let
φa(√p)=φa(p−1∑x=0ζx2)=p−1∑x=0ζax2=(ap)√p=−√p |
by the evaluation of quadratic Gauss sums (cf. [5,pp.70-75]). Hence
φa(ε−h(p)p)=(N(εp)εp)−h(p)=−εh(p)p |
where
(−1)|{0<k<p4: (kp)=−1}|∏1≤j<k≤(p−1)/2(ζaj2+ζak2)=φa(ε−h(p)p)=−εh(p)p=(ap)ε−(ap)h(p)p. |
In view of the above, we have proven Theorem 1.1(ⅱ).
Lemma 2.2. Let
|{(j,k): 1≤j<k≤p−12 {aj2}p>{ak2}p}|+|{(j,k): 1≤j<k≤p−12 {ak2−aj2}p>p2}|≡|{(j,k): 1≤j<k≤p−12 |{aj2}p−{ak2}p|>p2}| (mod 2). | (2.3) |
Proof. This can be easily checked by distinguishing the cases
Proof of Theorem 1.2. In view of Lemma 2.2, it suffices to show that
|{(j,k): 1≤j<k≤p−12 |{aj2}p−{ak2}p|>p2}|≡|{1≤k<p4: (akp)=1}| (mod 2). | (2.4) |
As
|{aj2∗}p−{ak2∗}p|=|(p−{aj2}p)−(p−{ak2}p)|=|{aj2}p−{ak2}p|. |
If
|{(j,k): 1≤j<k≤p−12 |{aj2}p−{ak2}p|>p2}|≡12|{1≤j≤p−12: |{aj2}p−{aj2∗}|=|2{aj2}p−p|>p2}|=12|{1≤j≤p−12: {aj2}p<p4 or {aj2}p>34p}|=12|{1≤j≤p−12: {aj2}p<p4}|+12|{1≤j≤p−12: {aj2∗}p<p4}|=|{1≤j≤p−12: {aj2}p<p4}|=|{1≤k<p4: (akp)=1}| (mod 2). |
This proves the desired (2.4). So (1.6) holds.
We first need a result of Sun [7].
Lemma 3.1. Let
(−1)|{(j,k): 1≤j<k≤n {aj2}p>{ak2}p}|={1 if p≡3 (mod 8),(−1)(h(−p)+1)/2(ap) if p≡7 (mod 8). | (3.1) |
Proof. By Sun [7,Theorem 1.4(ⅱ)],
∏1≤j<k≤(p−1)/2(cotπaj2p−cotπak2p)={(2p−1/p)(p−3)/8if p≡3 (mod 8),(−1)(h(−p)+1)/2(ap)(2p−1/p)(p−3)/8if p≡7 (mod 8). |
This implies (3.1) since for any
cotπaj2p<cotπak2p⟺{aj2}p>{ak2}p. |
We are done.
Theorem 3.2. Let
(−1)|{(s,t): 0≤t<s≤n {as2−b}p>{at2−b}p}|−|{0<r<b: (rp)=(ap)}|={1 if p≡3 (mod 8),(−1)(h(−p)−1)/2(ap) if p≡7 (mod 8). | (3.2) |
Proof. Let
[{as2−b}p>{at2−b}p]+[{as2}p>{at2}p] |
is odd if and only if
{as2}p≥b>{at2}p or {at2}p≥b>{as2}p, |
where for an assertion
[A]={1if A holds,0otherwise. |
Note that
|{(s,t): 0≤t<s≤n, {as2}p≥b>{at2}p or {as2}p<b≤{at2}p}|=|{(r1,r2): 0≤r1<b≤r2≤p−1 (ar1p),(ar2p)≠−1}|=|{0≤r<b: (arp)≠−1}|×(p+12−|{0≤r<b: (arp)≠−1}|)≡|{0≤r<b: (arp)≠−1}|=1+|{0<r<b: (rp)=(ap)}| (mod 2) |
and
|{(s,t): 0≤t<s≤n {as2}p>{at2}p}|=(n+12)−|{(s,t): 0≤t<s≤n {as2}p<{at2}p}| |
with
Lemma 4.1. Let
(ⅰ) (Dirichlet (cf. [5,p.238])) If
(2−(2p))h(−p)=(p−1)/2∑k=1(kp). |
(ⅱ) (B. C. Berndt and S. Chowla [1]) If
Proof of Theorem 1.3. We just prove the second part in details since the first part can be proved similarly.
Write
a=p+12 and b={(5p+1)/8if p≡3 (mod 8),(p+1)/8if p≡7 (mod 8). |
For any
Tn−r=n(n+1)2−(2n+1)r2+r22≡ar2−b (mod p). |
Thus
|{(j,k): 0≤j<k≤n & {Tj}p>{Tk}p}|=|{(t,s): 0≤t<s≤n & {Tn−s}p>{Tn−t}p}|=|{(t,s): 0≤t<s≤n & {as2−b}p>{at2−b}p}|. |
Note that
B:=|{0<r<b: (rp)=(2p)}|. | (4.1) |
Applying Theorem 3.2, from the above we obtain
|{(j,k): 1≤j<k≤n & {Tj}p>{Tk}p}|≡B+{0 (mod 2) if p≡3 (mod 8),(h(−p)−1)/2 (mod 2) if p≡7 (mod 8). | (4.2) |
When
B+1=|{1≤k≤p+18: (kp)=1}| |
and hence (1.8) follows from (4.2).
Below we handle the case
B=(p−1)/2∑k=11−(kp)2+|{p2<k<5p+18: (2k−pp)=1}|=p−14−12(p−1)/2∑k=1(kp)+|{0<r<p+14: 2∤r (rp)=1}|. |
Applying Lemma 4.1, we obtain
B=p−14−3h(−p)2+∑0<k<p/41+(kp)2−|{0<r<p+14: 2∣r (rp)=1}|≡h(−p)+12+p−38−|{0<k<p+18: (2kp)=1}|=h(−p)+12+|{0<k<p+18: (2kp)=−1}|=h(−p)+12+|{1≤k≤⌊p+18⌋: (kp)=1}| (mod 2). |
So, in this case, (1.8) also follows from (4.2).
We would like to thank the referee for helpful comments.
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