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Research article Special Issues

Effects of dispersed fibres in myocardial mechanics, Part I: passive response


  • It is widely acknowledged that an imbalanced biomechanical environment can have significant effects on myocardial pathology, leading to adverse remodelling of cardiac function if it persists. Accurate stress prediction essentially depends on the strain energy function which should have competent descriptive and predictive capabilities. Previous studies have focused on myofibre dispersion, but not on fibres along other directions. In this study, we will investigate how fibre dispersion affects myocardial biomechanical behaviours by taking into account both the myofibre dispersion and the sheet fibre dispersion, with a focus on the sheet fibre dispersion. Fibre dispersion is incorporated into a widely-used myocardial strain energy function using the discrete fibre bundle approach. We first study how different dispersion affects the descriptive capability of the strain energy function when fitting to ex vivo experimental data, and then the predictive capability in a human left ventricle during diastole. Our results show that the chosen strain energy function can achieve the best goodness-of-fit to the experimental data by including both fibre dispersion. Furthermore, noticeable differences in stress can be found in the LV model. Our results may suggest that it is necessary to include both dispersion for myofibres and the sheet fibres for the improved descriptive capability to the ex vivo experimental data and potentially more accurate stress prediction in cardiac mechanics.

    Citation: Debao Guan, Yuqian Mei, Lijian Xu, Li Cai, Xiaoyu Luo, Hao Gao. Effects of dispersed fibres in myocardial mechanics, Part I: passive response[J]. Mathematical Biosciences and Engineering, 2022, 19(4): 3972-3993. doi: 10.3934/mbe.2022183

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  • It is widely acknowledged that an imbalanced biomechanical environment can have significant effects on myocardial pathology, leading to adverse remodelling of cardiac function if it persists. Accurate stress prediction essentially depends on the strain energy function which should have competent descriptive and predictive capabilities. Previous studies have focused on myofibre dispersion, but not on fibres along other directions. In this study, we will investigate how fibre dispersion affects myocardial biomechanical behaviours by taking into account both the myofibre dispersion and the sheet fibre dispersion, with a focus on the sheet fibre dispersion. Fibre dispersion is incorporated into a widely-used myocardial strain energy function using the discrete fibre bundle approach. We first study how different dispersion affects the descriptive capability of the strain energy function when fitting to ex vivo experimental data, and then the predictive capability in a human left ventricle during diastole. Our results show that the chosen strain energy function can achieve the best goodness-of-fit to the experimental data by including both fibre dispersion. Furthermore, noticeable differences in stress can be found in the LV model. Our results may suggest that it is necessary to include both dispersion for myofibres and the sheet fibres for the improved descriptive capability to the ex vivo experimental data and potentially more accurate stress prediction in cardiac mechanics.



    Let p be an odd prime. It is well known that the numbers

    12, 22, , (p12)2

    are pairwise incongruent modulo p, and they give all the (p1)/2 quadratic residues modulo p. Recently Z.-W. Sun [7] initiated the study of permutations related to quadratic residues modulo p as well as evaluations of related products involving pth roots of unity; many of his results in [7] are related to the class number of the quadratic field Q((1)(p1)/2p). In this paper, we confirm some conjectures of Sun [7] in this new direction.

    Let p>3 be a prime and let ζ=e2πi/p. Let aZ with pa. Recently, Z.-W. Sun [7,Theorem 1.3(ⅱ)] showed that

    1j<k(p1)/2(ζaj2ζak2)={±i(p1)/4p(p3)/8ε(ap)h(p)/2p                      if p1 (mod 4),(p)(p3)/8                                              if p3 (mod 8),(1)(p+1)/8+(h(p)1)/2(ap)p(p3)/8i         if p7 (mod 8),

    where (ap) is the Legendre symbol, εp with p1 (mod 4) is the fundamental unit of the real quadratic field Q(p), and h(d) with d0,1 (mod 4) not a square is the class number of the quadratic field with discriminant d. Sun [7,Theorem 1.5] also proved that

    (1)ap+12p142(p1)(p3)/81j<k(p1)/2cosπa(k2j2)p=1j<k(p1)/2(ζaj2+ζak2)={1if p3 (mod 4),±ε(ap)h(p)((2p)1)/2pif p1 (mod 4). (1.1)

    Our first theorem confirms [7,Conjecture 6.7].

    Theorem 1.1. Let p be a prime with p1 (mod 4), and let ζ=e2πi/p. Let a be an integer not divisible by p.

    (i) If p1 (mod 8), then

    1j<k(p1)/2(ζaj2+ζak2)=(1)|{1k<p4: (kp)=1}|. (1.2)

    (ii) When p5 (mod 8), we have

    (1)|{1k<p4: (kp)=1}|1j<k(p1)/2(ζaj2+ζak2)=(ap)ε(ap)h(p)p. (1.3)

    Remark 1.1. Let p be a prime with p1 (mod 4). Then (p12!)21 (mod p) by Wilson's theorem. We may write p=x2+y2 with x,yZ, x1 (mod 4) and yp12!x (mod p). As y2p1 (mod 8), we see that y(2p)1 (mod 4). By a result of K. Burde [3], we have

    |{1k<p4: (kp)=1}|0 (mod 2)y(2p)1 (mod 8).

    Thus

    (1)|{1k<p4: (kp)=1}|=(1)p14(1)14(y(2p)+1)=(1)y4. (1.4)

    Let p be an odd prime. For each aZ we let {a}p denote the least nonnegative residue of a modulo p. Define

    s(p):=|{(j,k): 1j<kp12  {j2}p>{k2}p}|

    and

    t(p):=|{(j,k): 1j<kp12  {k2j2}p>p2}|

    as in [7], where (j,k) is an ordered pair. Sun [7,Theorem 1.4(ⅰ)] showed that

    (1)s(p)=(1)t(p)={1if p3 (mod 8),(1)(h(p)+1)/2if p7 (mod 8).

    He also conjectured that (cf. [7,Conjecture 6.1]) if p1 (mod 4) then

    s(p)+t(p)|{1k<p4: (kp)=1}| (mod 2). (1.5)

    Our second theorem in the case a=1 confirms this conjecture.

    Theorem 1.2. Let p be a prime with p1 (mod 4), and let aZ with pa. Then

    |{(j,k): 1j<kp12  {aj2}p>{ak2}p}|+|{(j,k): 1j<kp12  {ak2aj2}p>p2}||{1k<p4: (kp)=(ap)}| (mod 2). (1.6)

    Our third theorem was first conjectured by Sun (cf. [7,Conjectures 6.3 and 6.4]).

    Theorem 1.3. Let p be a prime with p3 (mod 4).

    (i) We have

    (1)|{(j,k): 1j<k(p1)/2 and {j(j+1)}p>{k(k+1)}p}|=(1)(p+1)/8. (1.7)

    (ii) Suppose p>3 and write Tm=m(m+1)/2 for mN. Then

    (1)|{(j,k): 1j<k(p1)/2  {Tj}p>{Tk}p}|=(1)h(p)+12+|{1kp+18: (kp)=1}|. (1.8)

    We will prove Theorems 1.1-1.2 in Section 2. Based on an auxiliary theorem given in Section 3, we are going to prove Theorem 1.3 in Section 4.

    In 2006, H. Pan [6] obtained the following lemma.

    Lemma 2.1. (H. Pan [6]) Let n>1 be an odd integer and let c be any integer relatively prime to n. For each j=1,,(n1)/2 let πc(j) be the unique r{1,,(n1)/2} with cj congruent to r or r modulo n. For the permutation πc on {1,,(n1)/2}, its sign is given by

    sign(πc)=(cn)(n+1)/2,

    where (cn) is the Jacobi symbol.

    Proof of the First Part of Theorem 1.1. As p1 (mod 8), there is an integer c with c22 (mod p). For j=1,,(p1)/2 let πc(j) be the unique r{1,,(p1)/2} with cj congruent to r or r modulo p. Then πc is a permutation on {1,,(p1)/2}, and

    1j<k(p1)/2ζ2aj2ζ2ak2ζaj2ζak2=1j<k(p1)/2ζaπc(j)2ζaπc(k)2ζaj2ζak2=(1)|{(j,k): 1j<k(p1)/2  πc(j)>πc(k)}|=sign(πc)=(cp)

    with the aid of Lemma 2.1. In view of K. S. Williams and J. D. Currie [8,(1.4)], we have

    (cp)c(p1)/2=(c2)(p1)/42(p1)/4(1)|{0<k<p4: (kp)=1}| (mod p).

    Therefore (1.2) holds in the case p1 (mod 8).

    Remark 2.1. Our method to prove part (ⅰ) of Theorem 1.1 does not work for part (ⅱ) of Theorem 1.1.

    Proof of the Second Part of Theorem 1.1. We distinguish two cases.

    Case 1. (ap)=1.

    In this case,

    {{aj2}p: 1jp12}={{k2}p: 1kp12}

    So it suffices to show (1.3) for a=1. In view of (1.1) with a=1, we only need to prove that

    (1)|{0<k<p4: (kp)=1}|1j<k(p1)/2(ζj2+ζk2)>0. (2.1)

    As (1p)=1, for each 1j(p1)/2 there is a unique integer j{1,,(p1)/2} such that pj2j2 (mod p). As (2p)=1, we have jj. For any distinct j,k{1,,(p1)/2}, we have ζj2+ζk20 (since ζ2j2ζ2k2) and

    (ζj2+ζk2)(ζj2+ζk2)=(ζj2+ζk2)(ζj2+ζk2)=|ζj2+ζk2|2>0;

    also,

    {j,k}={j,k}j=k and k=jj=k.

    For 1j(p1)/2, clearly

    ζj2+ζj2=ζj2+ζj2=2cos2πj2p=2cos2πj2p

    and hence

    ζj2+ζj2>0cos2πj2p>0{j2}p<p4 or {j2}p<p4.

    Thus the sign of the product

    1j<k(p1)/2pj2+k2(ζj2+ζk2)=(1)(p1)/41j<j(p1)/2(ζj2ζj2)

    is

    (1)(p1)/4|{1k<p4: (kp)=1}|=(1)|{1k<p4: (kp)=1}|.

    So (2.1) holds and (1.3) follows.

    Case 2. (ap)=1.

    By the discussion in Case 1, we have

    (1)|{0<k<p4: (kp)=1}|1j<k(p1)/2(ζj2+ζk2)=εh(p)p. (2.2)

    Let φa be the element of the Galois group Gal(Q(ζ)/Q) with φa(ζ)=ζa. Then

    φa(p)=φa(p1x=0ζx2)=p1x=0ζax2=(ap)p=p

    by the evaluation of quadratic Gauss sums (cf. [5,pp.70-75]). Hence

    φa(εh(p)p)=(N(εp)εp)h(p)=εh(p)p

    where N(εp) is the norm of εp with respect to the field extension Q(ζ)/Q, and we have used the known results N(εp)=1 and 2h(p) (cf. [4,p.185 and p.187]). Thus, by applying the automorphism φa to the identity (2.2), we get

    (1)|{0<k<p4: (kp)=1}|1j<k(p1)/2(ζaj2+ζak2)=φa(εh(p)p)=εh(p)p=(ap)ε(ap)h(p)p.

    In view of the above, we have proven Theorem 1.1(ⅱ).

    Lemma 2.2. Let p be an odd prime, and let aZ with pa. Then

    |{(j,k): 1j<kp12  {aj2}p>{ak2}p}|+|{(j,k): 1j<kp12  {ak2aj2}p>p2}||{(j,k): 1j<kp12  |{aj2}p{ak2}p|>p2}| (mod 2). (2.3)

    Proof. This can be easily checked by distinguishing the cases {aj2}p<{ak2}p and {aj2}p>{ak2}p for 1j<k(p1)/2.

    Proof of Theorem 1.2. In view of Lemma 2.2, it suffices to show that

    |{(j,k): 1j<kp12  |{aj2}p{ak2}p|>p2}||{1k<p4: (akp)=1}| (mod 2). (2.4)

    As (1p)=1, for each 1j(p1)/2 there is a unique integer j{1,,(p1)/2} such that j2j2 (mod p) and hence aj2aj2 (mod p). Clearly, |{1j(p1)/2: j=j}|1. Note that

    |{aj2}p{ak2}p|=|(p{aj2}p)(p{ak2}p)|=|{aj2}p{ak2}p|.

    If j and k are distinct elements of {1,,(p1)/2}, then {j,k}={j,k} if and only if j=k and k=j. Thus

    |{(j,k): 1j<kp12  |{aj2}p{ak2}p|>p2}|12|{1jp12: |{aj2}p{aj2}|=|2{aj2}pp|>p2}|=12|{1jp12: {aj2}p<p4 or {aj2}p>34p}|=12|{1jp12: {aj2}p<p4}|+12|{1jp12: {aj2}p<p4}|=|{1jp12: {aj2}p<p4}|=|{1k<p4: (akp)=1}| (mod 2).

    This proves the desired (2.4). So (1.6) holds.

    We first need a result of Sun [7].

    Lemma 3.1. Let p=2n+1 be a prime with n odd, and let aZ with pa. Then

    (1)|{(j,k): 1j<kn  {aj2}p>{ak2}p}|={1                                    if p3 (mod 8),(1)(h(p)+1)/2(ap)       if p7 (mod 8). (3.1)

    Proof. By Sun [7,Theorem 1.4(ⅱ)],

    1j<k(p1)/2(cotπaj2pcotπak2p)={(2p1/p)(p3)/8if p3 (mod 8),(1)(h(p)+1)/2(ap)(2p1/p)(p3)/8if p7 (mod 8).

    This implies (3.1) since for any 1j<k(p1)/2 we have

    cotπaj2p<cotπak2p{aj2}p>{ak2}p.

    We are done.

    Theorem 3.2. Let p=2n+1 be a prime with n odd, and let a,b{1,,p1}. Then

    (1)|{(s,t): 0t<sn  {as2b}p>{at2b}p}||{0<r<b: (rp)=(ap)}|={1                                    if p3 (mod 8),(1)(h(p)1)/2(ap)       if p7 (mod 8). (3.2)

    Proof. Let 0t<sn. By comparing {as2}p and {at2}p with b, we verify case by case that

    [{as2b}p>{at2b}p]+[{as2}p>{at2}p]

    is odd if and only if

    {as2}pb>{at2}p  or  {at2}pb>{as2}p,

    where for an assertion A we define

    [A]={1if A holds,0otherwise.

    Note that

    |{(s,t): 0t<sn, {as2}pb>{at2}p or {as2}p<b{at2}p}|=|{(r1,r2): 0r1<br2p1  (ar1p),(ar2p)1}|=|{0r<b: (arp)1}|×(p+12|{0r<b: (arp)1}|)|{0r<b: (arp)1}|=1+|{0<r<b: (rp)=(ap)}| (mod 2)

    and

    |{(s,t): 0t<sn  {as2}p>{at2}p}|=(n+12)|{(s,t): 0t<sn  {as2}p<{at2}p}|

    with (n+12)p+14 (mod 2). Combining the above with (3.1), we finally obtain (3.2).

    Lemma 4.1. Let p be a prime with p3 (mod 4).

    (ⅰ) (Dirichlet (cf. [5,p.238])) If p>3 then

    (2(2p))h(p)=(p1)/2k=1(kp).

    (ⅱ) (B. C. Berndt and S. Chowla [1]) If p3 (mod 8), then 0<k<p/4(kp)=0. If p7 (mod 8), then p/4<k<p/2(kp)=0.

    Proof of Theorem 1.3. We just prove the second part in details since the first part can be proved similarly.

    Write n=(p1)/2, and set

    a=p+12  and  b={(5p+1)/8if p3 (mod 8),(p+1)/8if p7 (mod 8).

    For any rZ, we have

    Tnr=n(n+1)2(2n+1)r2+r22ar2b (mod p).

    Thus

    |{(j,k): 0j<kn & {Tj}p>{Tk}p}|=|{(t,s): 0t<sn & {Tns}p>{Tnt}p}|=|{(t,s): 0t<sn & {as2b}p>{at2b}p}|.

    Note that (ap)=(2p). Set

    B:=|{0<r<b: (rp)=(2p)}|. (4.1)

    Applying Theorem 3.2, from the above we obtain

    |{(j,k): 1j<kn & {Tj}p>{Tk}p}|B+{0 (mod 2)                             if p3 (mod 8),(h(p)1)/2 (mod 2)       if p7 (mod 8). (4.2)

    When p7 (mod 8), we have

    B+1=|{1kp+18: (kp)=1}|

    and hence (1.8) follows from (4.2).

    Below we handle the case p3 (mod 8). Observe that

    B=(p1)/2k=11(kp)2+|{p2<k<5p+18: (2kpp)=1}|=p1412(p1)/2k=1(kp)+|{0<r<p+14: 2r  (rp)=1}|.

    Applying Lemma 4.1, we obtain

    B=p143h(p)2+0<k<p/41+(kp)2|{0<r<p+14: 2r  (rp)=1}|h(p)+12+p38|{0<k<p+18: (2kp)=1}|=h(p)+12+|{0<k<p+18: (2kp)=1}|=h(p)+12+|{1kp+18: (kp)=1}| (mod 2).

    So, in this case, (1.8) also follows from (4.2).

    We would like to thank the referee for helpful comments.



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