Research article

The role of electric charge in SARS-CoV-2 and other viral infections

  • Received: 02 February 2024 Revised: 07 May 2024 Accepted: 14 May 2024 Published: 23 May 2024
  • This study analyzed the role of electric charge in human viral infections. Examples of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), dengue, Ebola, influenza A, and respiratory syncytial virus (RSV) are presented. Charge distribution in SARS-CoV-2 and electrostatic interactions of SARS-CoV-2 with its receptor, angiotensin-converting enzyme 2 (ACE2), were evaluated, and the mean time required for respired SARS-CoV-2 virus attachment was evaluated. The virus–cell attachment modality of all of the above viruses was calculated. The impact of electric charge on other viral-related processes, such as replication of virion material, release, and immune response, was also discussed. Special charge conditions in virus treatments were also indicated.

    Citation: Piotr H. Pawłowski, Piotr Zielenkiewicz. The role of electric charge in SARS-CoV-2 and other viral infections[J]. AIMS Biophysics, 2024, 11(2): 166-188. doi: 10.3934/biophy.2024011

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  • This study analyzed the role of electric charge in human viral infections. Examples of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), dengue, Ebola, influenza A, and respiratory syncytial virus (RSV) are presented. Charge distribution in SARS-CoV-2 and electrostatic interactions of SARS-CoV-2 with its receptor, angiotensin-converting enzyme 2 (ACE2), were evaluated, and the mean time required for respired SARS-CoV-2 virus attachment was evaluated. The virus–cell attachment modality of all of the above viruses was calculated. The impact of electric charge on other viral-related processes, such as replication of virion material, release, and immune response, was also discussed. Special charge conditions in virus treatments were also indicated.



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    Conflict of interest



    The authors declare that there are no conflicts of interest.

    Author contributions



    PH Pawłowski: Conceived and designed the theoretical models, analyzed data, and drafted the manuscript. P Zielenkiewicz: Critical feedback, data analysis, and revised the manuscript.

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