Citation: Madison L. Wallace, Ken S. Rosenthal. Vaccine protection of the mother, the fetus, neonates and infants[J]. AIMS Allergy and Immunology, 2024, 8(2): 124-145. doi: 10.3934/Allergy.2024007
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A problem of significant interest and importance in solid mechanics is the analysis of delamination phenomena in joined solids. In this sense, composite laminates, materials with inclusions, masonry structures with mortar beds, may be considered as typical joined bodies. The structural response of joined solids strongly depends on the mechanical behaviour of the internal adhesive layers, where several microstructural failure mechanisms lead to progressive degradation of the mechanical properties, up to complete delamination (macrocrack). Moreover, under compressive loading conditions, macrocraks may close and produce frictional effects.
Adhesive layers are generally modelled as zero thickness surfaces by means of interface mechanical device, whose internal constitutive law is defined as a relation between traction and jump-displacement components.
Interface constitutive modelling may be formulated at mesoscale level, reproducing the average mechanical behaviour of an adhesive material portion, known as representative surface element (RSE) whose size is sufficiently large with respect to the microstructure characteristic dimensions.
In the literature, interface constitutive laws have been initially used in the pioneering cohesive-zone models of Dugdale and Barenblatt [1,2], to describe the progressive separation process in the fracture process zone (FPZ). These cohesive-zone models are defined in the framework of fracture mechanics, possibly coupled with damage mechanics or with plasticity theory. Interface models in the analysis of composite delamination are developed in the damage mechanics framework [3,4,5,6,7,8,9,10,11], where plastic and frictional phenomena are neglected. Alternative formulations [12,13,14] are developed in the framework of non-associative softening-plasticity theory, allow to catch the residual frictional behaviour of the fully cracked material.
Cohesive damaging with residual frictional effects has been initially proposed in [15] for composite laminates and improved in [16,17]. In [18] and, by the same author in [19,20,21], an original mesoscale interpretation of the damage parameter allows to model the transition from the pure cohesive damaging behaviour of the sound material to the pure frictional behaviour of the fully cracked one. In [20], the cohesive-frictional constitutive model has been successfully used for the analysis of frictional effects in Mode Ⅱ delamination tests of composite material, focusing the attention on experimental tests, which were been performed with an increasing cycling loading path. In the present paper the theoretical and computational issues, related to the use of a cohesive-frictional model combined with the kinematic formulation of XFEM, are analysed in detail.
Most of the proposed constitutive models assume the initial behaviour of interface as elastic, by a linear relationship between traction and jump displacement. The normal and tangential elastic parameters are defined in function of the elastic behaviour of the adhesive medium keeping joined the two bodies. For problems of joined solids without any adhesive layer, where bodies are directly bonded one each other, the initial elastic behaviour is assumed as an approximate penalty approach to numerically simulate the mechanical constrain between the bodies.
From the kinematical point of view, the joining surface is modelled as jump displacement between the edges of the joined bodies to describe opening and relative sliding phenomena in the delamination phase. Jump displacements can be active also in the interface sound condition and considered as elastic deformation, which can produce material penetration in compressive state, or elastic delamination in tensile state. In order to bound such effects, a high initial elastic stiffness has to be assumed, but it can produce numerical problems such as spurious traction oscillations, as shown in [22].
In the framework of FEM resolution strategy, adhesive layers are generally modelled by means of interface elements, which are defined in a zero thickness domain (surface element for 3D mechanical problems or linear element for 2D mechanical problems) connecting, node by node, the meshes of the joined bodies. Interface finite elements are of simple implementation but, as a drawback, they require two different meshes for the connected bodies with coincident nodes on the connecting surface. Generally, the domain discretization problem by use of interface elements can be quit burdensome.
An alternative formulation is the extended finite element method (XFEM), which allows to define discontinuous displacement fields inside a generic domain, without the need of the mesh to be conforming to the discontinuity surface. The standard displacement based formulation is enriched by a discontinuous displacement field, which is governed by additional degrees of freedom. The spatial position of displacements discontinuity is implicitly defined by the level set method and it can be arbitrarily positioned inside the mesh.
The XFEM has been developed by Belytschko el al. [23,24] to model crack formation and propagation, voids and inhomogeneity. Several XFEM schemes have been developed and proposed in literature: for two dimensional linear elastic fracture mechanics (LEFM) in [23], with the step function enrichment in [24], for three dimensional crack propagation in [25], for material discontinuity problems in [26,27], with second-order XFEM formulation in [27], for cohesive crack models in [28,29,30]. The XFEM formulation has also been proposed for the modelling of physically existing discontinuity surface. In [31], XFEM and level set method are analysed for the modelling of interface material failure with a damage separation law for the interface, neglecting frictional effects. In [32], the XFEM formulation has been employed to model the frictional effects on the contact surface between two adjacent bodies, but neither decohesion nor delamination have been considered. In [33], the material microstructure has been modelled by XFEM formulation, including voids and material interface, in a finite element multiscale resolution strategy. In [34], material interface has been modelled in a higher order XFEM framework, including curved discontinuity surface, for which attention is focused on the integration procedure and convergence of numerical solutions.
The main target of the present paper is the modelling, in a unified framework, of several mechanical problems such as: frictional contact, delamination, decohesion and smooth transition from the initial cohesive behaviour up to the frictional residual on. Such a complex mechanical behaviour can be modelled, for a joining or discontinuity surface, in the kinematic framework of XFEM, for which the interface can be geometrically placed arbitrarily in a unique mesh, without the requirement of defining two or more meshes with coincident nodes at the joining surface.
The implemented constitutive model has been developed by the same author in [19]. The solution proposed in the present paper is limited to two-dimensional problems for which the connection surface is geometrically represented by a line. The finite element formulation is based on the triangular six nodes eXtended element published in [30], which allows to model displacement fields with a strong discontinuity at a generic line inside the mesh.
Consider two solid domains Ωa and Ωb perfectly bonded and in mutual contact on the common internal surface Γc, with applied external tractions t on the free boundary Γt and with imposed displacement ˉu on Γu, as represented in Figure 1a in a two-dimensional case. The hypotheses of homogeneous material and small strain are assumed. In Figure 1b the overall domain Ω=Ωa∪Ωb is discretized in triangular finite elements and the mesh does not conform the internal connecting surface Γc.
The kinematic formulation developed in [30] allows to model a discontinuous displacement field for both the partially cracked finite element ("crack tip element") and for the completely cracked finite element. Moreover both a first-order scheme, with a three node triangular element and a second-order scheme, with a six node triangular element, are developed.
The displacement field of the whole domain Ω is defined as the additive combination of a continuous part uc and a discontinuous one ud :
u(x)=uc(x)+ud(x) | (1) |
where the continuous part is defined by standard shape functions
uc(x)=∑i∈INi(x)ui | (2) |
and I is the set of all nodes of the meshed domain and ui is the displacement vector of the i-th node. With reference to domain Ωenr, defined by the set of elements entirely intersected by the connecting surface Γc, and the relevant set on nodes Ienr⊂I, the discontinuous part of the displacement field is written in the following form
ud(x)=∑i∈IenrNi(x)Ψi(x)ai | (3) |
where Ψi(x) is the enrichment function and ai contains the relevant degree of freedoms.
The spatial position of the connecting surface Γc is defined by the level set method, that is
Γc={x∈Ω:ϕ(x)=0} | (4) |
where function ϕ(x) assumes different signs in the two domain Ωa and Ωb and whose iso-zero curve coincides with surface Γc, as shown in Figure 1a. A local reference with tangential and normal axes (t,n) is defined at a generic point of the connecting surface Γc and the normal axis n is oriented towards the positive values of level set function.
For elements completely intersected by the surface Γc, the enrichment function is defined as
Ψi(x)=12sign(ϕ(x))−12sign(ϕi), i∈Ienr, x∈Ωenr | (5) |
where ϕi=ϕ(xi) is the level set value at the i-th node.
Due to the specific form of the enrichment functions Ψi(x), the enrichment displacement field vanishes outside the enriched elements, as shown in Figure 2 for a three node triangular element.
In the finite element framework the interface deformation is defined as a jump displacement between the adjacent edges of the two connected bodies, lying on the surface Γc. The jump displacement across the connecting surface Γc is defined as the difference of displacement between the two adjacent points on the positive and on the negative part of Γc, that is
[[u(x)]]=u(x+)−u(x−), x∈Γc | (6) |
where x+ and x− are points respectively on the positive side of Γc and on its negative side, with reference to the sign of the level-set function. By substitution of Eqs 1, 2, 3 and 5 in Eq 6, it can be observed that jump displacement is function of the enriching parameters ai, that is
[[u(x)]]=∑i∈IenrNi(x)ai, x∈Γc | (7) |
In the present paper, the initial behaviour of the interface is assumed elastic and the jump displacements can be different than zero also in the undamaged state of the connecting surface. The enriching degrees of freedom ai with i∈Ienr, which belong to nodes contained in the domain Ωenr of elements crossed by the interface, are always unconstrained and some numerical problems, such as spurious traction oscillations, can emerge (see [22]).
In [31], two different formulations are considered respectively for the sound interface and for the cracked one. In the former case, the finite element model is enhanced with a weak discontinuity field, in order to model the kinematical behaviour at the initial state, when the two bodies are perfectly bonded with zero jump displacements and with independent deformation states on the two element parts. Finally, when in a finite element the internal interface attains the delamination condition, the element is enriched with a strong discontinuity field by releasing the relevant degrees of freedom. Nevertheless, in such formulation numerical problem of stress singularity or high stress concentration are observed.
The position inside the mesh of the connecting surface is defined in the input file by means of linear or quadratic parametric equations, or circle equations. Inside a single finite element the connecting surface is linearised and the following intersection schemes are considered:
a) side to side, when connecting surface intersects two element sides (Figure 2);
b) node to side, when connecting surface contains one node and intersects its opposite side;
c) node to node, when connecting surface contains two vertex nodes;
d) one node, when connecting surface contains just one vertex node, without cutting the element internal domain.
In (a) and (b) schemes, the finite element is completely cut, whereas in scheme (c) the interface coincides with a finite element side.
The interface constitutive model proposed in [19] is adopted for the numerical analysis; the model is developed in two-dimensional space, with reference to a zero thickness linear interface and it is described in the present section.
Interface constitutive models typically link the displacement discontinuity [[u(x)]] and the adhesion forces t(x). As described in previous section, the kinematics is defined by the displacement discontinuity across the interface, and it can be decomposed in two components: the normal one (Mode Ⅰ) and the tangential one (Mode Ⅱ). The interface equilibrium condition imposes continuity of traction t across interface, therefore it is assumed t=t+=t−, where t+ and t− are the traction vectors, respectively, on the positive edge and on the negative one. Statics and kinematics of an infinitesimal element dS of the connecting surface Γc are represented in Figures 3a and b.
The proposed constitutive model is developed in the damage mechanics framework [35] considering the Representative Surface Element (RSE), whose size is assumed sufficiently large compared to the adhesive material inhomogeneities (Figure 4), and average damage in the RSE is defined as
ω=dScdS | (8) |
where dSc measures the area of the micro-cracked RSE portion and dS measures the RSE area.
The damage variable ω measures the specific areal crack density of the infinitesimal surface element dS and it allows us to define, at the material point, the extensions of the two complementary fractions: the micro-cracked one ωdS and of the sound one (1−ω)dS (see Figure 4). Two different constitutive laws can be formulated for the two fractions and the damage variable governs the progressive transition of the adhesive constitutive model from the initial elastic-cohesive behaviour to the residual frictional one. In particular, a cohesive linear elastic law is assumed for the sound fraction and a non-associative elastic-plastic constitutive relation, with Coulomb yield surface, is assumed for the cracked fraction. The compressive behaviour of both the sound fraction and the damaged one, is modelled as linearly elastic.
The constitutive model formulation is developed considering the index s for the sound fraction variables and index c for the micro-cracked fraction ones. For the sound fraction the elastic deformation is define as
δes=[[u]]−δps | (9) |
where δps measures the plastic contribution. For the cracked fraction, which is represented in Figure 5a, the variable δec measures the asperities elastic deformation, represented in Figure 5b, and it is defined by the following relation
where δpc measures the plastic component (sliding and dilatancy represented in Figure 5c) and δdc is the detachment jump displacement (Figure 5d).
The vector δpc represents the jump displacement caused by the irreversible sliding of asperities among each others and it develops when the limit of frictional strength is attained. Moreover, since frictional behaviour is active only for compressive normal traction, positive normal traction produces loss of contact between the crack edges, which is measured by the detachment displacement δdc.
The constitutive model is developed in a thermodynamic framework following the classic Coleman and Noll procedures (for more detail see [35,36,37]). The Helmholtz free energy density (for unit interface length) is defined as
Ψ=Ψel(δes,δec,ω)+Ψin(ξ)==12(1−ω)δeTsKsδes+12ωδeTcKcδec+Ψin(ξ) | (11) |
where Ψel and Ψin are respectively the elastic part and the internal one; Ks and Kc are diagonal elastic matrices, respectively, of the sound fraction and of the micro-cracked one; ξ is a scalar state internal variable, which governs damage hardening. The second thermodynamic principle, in the form of Clausius-Duhem inequality, imposes a pointwise positiveness of rate dissipation energy density given as the difference between the work done by external forces and the variation of the free energy, for any change of the state variables. This condition is mathematically written as
D=tT[[˙u]]−˙Ψ≥0, | (12) |
where rate of Helmholtz free energy is defined as
˙Ψ=∂Ψel∂ω˙ω+∂Ψel∂δes⋅˙δes+∂Ψel∂δec⋅˙δec+∂Ψin∂ξ˙ξ==−(Y˙ω−tTs˙δes−tTc˙δec−χ˙ξ) | (13) |
ts and tc are conjugated variable of the elastic deformations δes and δec, that is
ts=∂Ψel∂δes=(1−ω)Ks | (14) |
tc=∂Ψel∂δec=ωKcδec, | (15) |
Y is the energy release rate and χ is the static hardening-like variable
Y=−∂Ψel∂ω=12δeTsKsδes−12δeTcKcδec | (16) |
χ=∂Ψin∂ξ. | (17) |
For an elastic loading step, where ˙ω=0, ˙ξ=0, ˙δps=0 and ˙δpc=0, rate elastic deformations are ˙δes=˙δec=[[˙u]], dissipation has to be null (D=0) and after substitution Eq 12 reads
D=(t−ts−tc)T[[˙u]]=0. | (18) |
Since Eq 18 has to be verified for any elastic loading step [[˙u]], the following internal equilibrium condition is obtained
t=ts+tc | (19) |
and, after substitution of Eqs 14 and 15, the overall interface elastic traction-displacement relation is obtained
t=(1−ω)Ksδes+ωKcδec. | (20) |
Equation 20 is assumed to be valid also for inelastic loading steps, in which dissipation is
D=tTs˙δps+tTc˙δpc+Y˙ω−χ˙ξ≥0. | (21) |
where detachment δdc does not produce any dissipation.
Dissipation positiveness is ensured by means of suitable activation criteria, which govern the evolution of plastic and damaging phenomena. In particular, damage evolution is governed by the following yield function
ϕd(Y,χ)=Y−χ(ξ)−Y0≤0, | (22) |
with Y0 assumed as initial yielding threshold. The relevant flow rules with the loading-unloading conditions read
˙ω=∂ϕd∂Y˙λd=˙λd,˙ξ=−∂ϕd∂χ˙λd=˙λd,˙λd≥0,ϕd˙λd=0,˙ϕd˙λd=0. | (23) |
The damage hardening-like law is
χ(ξ):=12KsNˉu2e[(ˉufˉuf(1−ξ)+ˉueξ)2−1], | (24) |
where ˉue and ˉuf are jumps displacement limit values, respectively, at the elastic threshold and at the unitary damage condition in a pure tensile state and KsN is the normal elastic stiffness of the interface sound fraction. Hardening law in Eq 24 produce linear softening in the traction-jump displacement space and it produces the following simple Mode Ⅰ fracture energy
GI=12KsNˉueˉuf. | (25) |
Plastic phenomena in the sound fraction are neglected (δps=0), whereas, in micro-cracked fraction, plastic phenomena evolution is governed by means of the classical Coulomb yield function, generally used for frictional materials,
ϕp=|tcT|+αtcN≤0. | (26) |
under the hypothesis of non-associative plasticity, by means of the following plastic potential
Ωp=|tcT|+βtcN, | (27) |
where α and β, with α≥β, are respectively the frictional coefficient and the dilatancy one. The plastic flow rules and loading/unloading conditions are
˙δpcT=∂Ωp∂tcT˙λp=sgn(tcT)˙λp,˙δpcN=∂Ωp∂tcN˙λp=β˙λp,˙λp≥0,ϕp˙λp=0,˙ϕp˙λp=0. | (28) |
By substitution of Eqs 28 and 23 in Eq 21, dissipation assumes the following form
D=(|tcT|+βtcN)˙λp+Y0˙λd≥0 | (29) |
and positiveness is ensured for any damaging or plastic loading step. The cohesive-frictional interface constitutive model has been implemented in the open source finite element code FEAP [38]. The interface kinematics is implicitly defined inside the triangular six nodes extended finite element. The enrichment degrees of freedom are active for the nodes of all the finite elements crossed the joining surface ΓC; on the contrary, the other enrichment degrees of freedom are restrained. Three Gauss integration points are considered for each finite element, where the two components of the jump displacement are computed through Eq 7 and passed to the subroutine of the interface constitutive model, which give back the tractions components and the constitutive stiffness matrix. Details on the implementation of both user defined finite elements and user defined constitutive models can be found in [38].
The proposed interface constitutive model and the triangular extended finite element have been implemented in the open source finite element code FEAP [38]. The numerical results of delamination phenomenon in joined bodies are presented.
The first simulation is the two-dimensional analysis of delamination between a square matrix the the circular inclusion, represented in Figure 6 with dimensions and boundary conditions. Matrix and inclusion are considered as elastic isotropic with the following constitutive parameters: EM=40000 N/mm2, νM=0.2, EI=400000 N/mm2, νI=0.2. With reference to the proposed interface constitutive model, the elastic parameters of the sound fractions are: KsN=400000 N/mm,KsT=347830 N/mm; the elastic parameters of the cracked fractions are: KcN=400000 N/mm,KcT=6956.6 N/mm; the jump displacement limit values are ˉue=10−6 mm,ˉuf=5×10−5 mm; frictional and dilatancy coefficients are α=0.364,β=0.176.
The domains of the two joined solids are numerically modelled by the not conforming mesh of XFEM triangular elements represented in Figure 6c; they are also modelled by quadrilateral isoparametric elements and interface elements in the mesh represented in Figure 6b, which conforms to the joining surface between matrix and inclusion. The numerical responses carried out by the two approaches, XFEM and classical interface elements, are compared in terms of force vs displacement in Figure 7 and the results are numerically coincident. Figures 8a and b plot the maps of vertical normal stress carried out, respectively, at the reference loading steps a and b represented in Figure 7.
The second proposed simulation is the two-dimensional sliding test between two elastic solids in mutual contact along a curvilinear surface, without any cohesive strength. The configuration test is represented in Figure 9a together with the adopted mesh, which is defined for the whole domain and it does not conform the contact surface. The hypothesis of small displacement is assumed. In the considered sliding test, the lower elastic solid is constrained along the lower boundary side and the upper elastic solid is subjected to a constant vertical force Fy=1000 N and to a monotonically increasing horizontal displacement at the upper boundary side, as shown in Figure 9a. Rotation of the upper boundary side is restrained. The elastic parameters of the two solids are E=40000 N/mm2, ν=0.2; for the contacts surface, frictional and dilatancy coefficients respectively are α=tan20∘, β=0. The map of vertical stresses, obtained by the numerical simulation for the imposed horizontal displacement ux=3.0 mm, is plotted in Figure 9b. The results of the numerical simulation are plotted in Figure 10 in terms of horizontal displacement vs horizontal force. The second numerical simulation shows that the proposed formulation allows to model problems of frictional contact with a very simple mesh generation, where a quite complex contact surface is defined in the input file as an isoparametric quadratic function.
The last numerical simulation reproduces the experimental results of a three points bending test performed on a carbon fibres-epoxy composite beam, whose dimensions are represented in Figure 11. The composite panel has been manufactured by hand lay-up and vacuum-bag techniques by a sequence of 12 unidirectional plies of carbon fibres. A Mylar foil was inserted at the mid-plane of the composite panels during the lay-up process in order to produce a starter delamination crack. Four specimens have been tested under displacement control and simultaneously the crack extension has been monitored by an high resolution camera. The experimental test results are plotted in Figure 12 in terms of imposed displacement vs vertical reaction. The fracture energy values obtained for the four experimental tests are reported in Table 1 with the relevant mean value. The three points bending test has been numerically simulated by using a two-dimensional mesh of 9×110 six nodes extended triangular elements in plane strain condition. The composite material is assumed as elastic isotropic with the following constitutive parameters: E=80580 N/mm2 and ν=0.23. The interface constitutive parameters are: KsN=KsT=90000 N/mm, KcN=90000 N/mm,KcT=3000 N/mm; the jump displacement limit values are ˉue=6.9×10−4 mm,ˉuf=0.014593 mm; frictional and dilatancy coefficients respectively are α=tan35∘, β=0. The adopted constitutive parameters produces the fracture energy value GII=12KsN⋅ˉue⋅ˉuf=0.4531 N/mm. The results of the numerical simulation are compared to the experimental results in Figure 12 in terms of imposed displacement vs load P, showing a good agreement between the two results. The numerical simulation produces: the same stiffness in the elastic branch; the same values of load and imposed displacement at the delamination condition; a response close to the experimental data also in the post-delamination branch. Moreover, the set of parameters chosen for the cohesive law produce a mode Ⅱ fracture energy very close to the values obtained by the experimental data. The discretization of the pre-cracked specimen, by XFEM formulation, has been obtained by the generation the mesh of the overall rectangular domain and by defining, in the input file, the line of the pre-existing crack, with unitary damage, and the line of possible delamination. The discretization of the same problem with standard interface element would be extremely much more onerous.
Specimen number | Fracture energy GII [N/mm] |
1 | 0.4706 |
2 | 0.4737 |
3 | 0.4198 |
4 | 0.4481 |
Mean value | 0.4531 |
Finally, the map of horizontal normal stress at the maximum loading condition is plotted in Figure 13 for the whole specimen together with a zoom around the crack tip.
The first numerical simulation proposed in the present paper has been discretized either by the standard interface elements and by the extended finite elements and the results of the two numerical simulations are practically coincident, showing the effectiveness of the implemented XFEM formulation.
Whereas interface finite elements are of very simple implementation in a finite element code, the most difficult in their use is the discretization phase, which requires a separate mesh for each connected body, with coincident nodes of the discretized bodies on the joining surface. The domain discretization phase, by use of interface elements, can be quite burdensome. Some alternative formulations of non-matching interface elements have been proposed in literature [39,40], which allow the discretization of the two connected bodies with independent meshes. The two meshes can be defined with non-coincident nodes on the joining surface ΓC, with an easier discretization phase.
On the contrary, the principal advantage of the XFEM formulation in the modelling of different bodies connected by joining surface is the discretization. The whole domain can be discretized with a unique mesh and the position of joining surface can be analytically defined, with much lower time needed for such operation, with respect to the interface formulation. Moreover, the XFEM formulation allows also to model extrinsic cohesive law, with initial rigid behaviour. Disadvantages of the XFEM formulation is the implementation, which can be very onerous, and the mesh density of the joining surface, which cannot be easily controlled for each element.
The present paper proposes a unified approach for the modelling of friction and delamination phenomena on discontinuity surfaces, discretized in an overall mesh based on an XFEM formulation. The proposed approach allows us to model both the delamination phenomenon with crack propagation of two joined solids and the frictional contact phenomenon between two adjacent solids. The transition, from the initially cohesive behaviour with delamination phenomena, to the final behaviour with residual frictional strength is also considered.
The discontinuity surfaces has been arbitrarily defined inside the mesh in parametric formulation, a unique mesh can be defined for whole domain, including connected bodies and discontinuity surface. On the contrary, in a standard approach, separated meshes have to be defined for the connected or adjacent bodies and specific interface finite elements for the discontinuity surface. Moreover, the meshes of the adjacent or connected bodies have to be defined with spatially coincident nodes on the discontinuity surface.
Funding: The financial support of the Italian Ministry for University and Research (MIUR), under the grant PRIN-2015, project No.2015LYYXA8, "Multiscale mechanical models for the design and optimization of microstructured smart materials and metamaterials" is gratefully acknowledged.
The authors declare that they have no conflict of interest.
[1] |
Chan MY, Smith MA (2018) Infections in pregnancy. Comprehensive Toxicology . Amsterdam: Elsevier Science 232-249. https://doi.org/10.1016/B978-0-12-801238-3.64293-9 ![]() |
[2] |
Khan AM, Morris SK, Bhutta ZA (2017) Neonatal and perinatal infections. Ped Clin North America 64: 785-798. https://doi.org/10.1016/j.pcl.2017.03.008 ![]() |
[3] |
Etti M, Calvert A, Galiza E, et al. (2022) Maternal vaccination: a review of current evidence and recommendations. Am J Obstet Gynecol 226: 459-474. https://doi.org/10.1016/j.ajog.2021.10.041 ![]() |
[4] |
Kurasawa K (2023) Maternal vaccination-current status, challenges, and opportunities. J Obstet Gynaecol Res 49: 493-509. https://doi.org/10.1111/jog.15503 ![]() |
[5] |
Engmann C, Fleming JA, Khan S, et al. (2020) Closer and closer? Maternal immunization: current promise, future horizons. J Perinatol 40: 844-857. https://doi.org/10.1038/s41372-020-0668-3 ![]() |
[6] |
Mackin DW, Walker SP (2021) The historical aspects of vaccination in pregnancy. Best Practice Res Clin Obstetrics Gyn 76: 13-22. https://doi.org/10.1016/j.bpobgyn.2020.09.005 ![]() |
[7] |
Psarris A, Sindos M, Daskalakis G, et al. (2019) Immunizations during pregnancy: How, when and why. Eur J Obstetrics Gyn Reprod Biol 240: 29-35. https://doi.org/10.1016/j.ejogrb.2019.06.019 ![]() |
[8] |
Giles ML, Way SS, Marchant A, et al. (2023) Maternal vaccination to prevent adverse pregnancy outcomes: An underutilized molecular immunological intervention?. J Mol Biol 435: 168097. https://doi.org/10.1016/j.jmb.2023.168097 ![]() |
[9] | Centers for Disease Control, U.S.A. Immunization Schedules. Available from: https://www.cdc.gov/vaccines/schedules/index.html |
[10] | Centers for Disease Control, U.S.A. Pregnancy and Vaccination. Available from: https://www.cdc.gov/vaccines/pregnancy/index.html |
[11] | (2021) Centers for disease control and preventionEpidemiology and Prevention of Vaccine-Preventable Diseases. “The Pink Book”. Washington: D.C. Public Health Foundation. |
[12] | FDAVaccines Licensed for Use in the United States. Available from: https://www.fda.gov/vaccines-blood-biologics/vaccines/vaccines-licensed-use-united-states |
[13] | Strikas RA (2015) Advisory committee on immunization practices recommended immunization schedules for persons aged 0 through 18 years--United States, 2015. MMWR Morb Mortal Wkly Rep 64: 93-94. https://doi.org/10.1111/ajt.13293 |
[14] | Centers for Disease ControlGuidelines for vaccinating pregnant women. Available from: https://www.cdc.gov/vaccines/pregnancy/hcp-toolkit/guidelines.html#Passive%20Immunization%20During%20Pregnancy |
[15] |
Zhang HQ, Zhang QY, Yuan ZM, et al. (2023) The potential epidemic threat of Ebola virus and the development of a preventive vaccine. J Biosaf Biosecur 5: 67-78. https://doi.org/10.1016/j.jobb.2023.05.001 ![]() |
[16] |
Malik S, Kishore S, Nag S, et al. (2023) Ebola virus disease vaccines: development, current perspectives and challenges. Vaccines 11: 268. https://doi.org/10.3390/vaccines11020268 ![]() |
[17] |
Woolsey C, Geisbert TW (2021) Current state of Ebola virus vaccines: A snapshot. PLoS Pathog 17: e1010078. https://doi.org/10.1371/journal.ppat.1010078 ![]() |
[18] |
Zhang J, Zhang XF, Huang SJ, et al. (2015) Long-term efficacy of a hepatitis E vaccine. N Engl J Med 372: 914-922. https://doi.org/10.1056/NEJMoa1406011 ![]() |
[19] | WHOHepatitis E (2023). Available from: https://www.who.int/news-room/fact-sheets/detail/hepatitis-e |
[20] |
Ciglenecki I, Rumunu J, Wamala JF, et al. (2022) The first reactive vaccination campaign against hepatitis E. Lancet Inf Dis 22: 1110-1111. https://doi.org/10.1016/S1473-3099(22)00421-2 ![]() |
[21] | Centers for Disease ControlMalaria vaccines. Available from: https://www.cdc.gov/malaria/php/public-health-strategy/malaria-vaccines.html |
[22] |
Björkman A, Benn CS, Aaby P, et al. (2023) RTS, S/AS01 malaria vaccine—proven safe and effective?. Lancet Infect Dis 23: e318-e322. https://doi.org/10.1016/S1473-3099(23)00126-3 ![]() |
[23] |
Verma A, Anand A, Patel VA, et al. (2024) Breaking the malaria barrier: The WHO-approved R21/Matrix-M vaccine and its global impact-an editorial. Ann Med Surg (Lond) 86: 1824-1827. https://doi.org/10.1097/MS9.0000000000001648 ![]() |
[24] | McIntosh EDG (2020) Development of vaccines against the sexually transmitted infections gonorrhoea, syphilis, Chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus. Ther Adv Vaccines Immunother 8. https://doi.org/10.1177/2515135520923887 |
[25] |
De la Maza LM, Darville TL, Pal S (2021) Chlamydia trachomatis vaccines for genital infections: where are we and how far is there to go?. Expert Rev Vaccines 20: 421-435. https://doi.org/10.1080/14760584.2021.1899817 ![]() |
[26] |
Murray SM, McKay PF (2021) Chlamydia trachomatis: Cell biology, immunology and vaccination. Vaccine 39: 2965-2975. https://doi.org/10.1016/j.vaccine.2021.03.043 ![]() |
[27] |
Wagenlehner FME, Naber KG (2019) A step further in a vaccine for Escherichia coli. Lancet Infect Dis 19: 565-567. https://doi.org/10.1016/S1473-3099(19)30069-6 ![]() |
[28] |
Kowarik M, Wetter M, Haeuptle MA, et al. (2021) The development and characterization of an E. coli O25B bioconjugate vaccine. Glycoconj J 38: 421-435. https://doi.org/10.1007/s10719-021-09985-9 ![]() |
[29] |
Mayer RL, Verbeke R, Asselman C, et al. (2022) Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes. Nat Commun 13: 6075. https://doi.org/10.1038/s41467-022-33721-y ![]() |
[30] |
Haese EC, Thai VC, Kahler CM (2021) Vaccine candidates for the control and prevention of the sexually transmitted disease gonorrhea. Vaccines 9: 804. https://doi.org/10.3390/vaccines9070804 ![]() |
[31] |
Jefferson A, Smith A, Fasinu PS, et al. (2021) Sexually transmitted Neisseria gonorrhoeae infections-update on drug treatment and vaccine development. Medicines (Basel) 8: 11. https://doi.org/10.3390/medicines8020011 ![]() |
[32] |
Lin EY, Adamson PC, Klausner JD (2021) Epidemiology, Treatments, and vaccine development for antimicrobial-resistant Neisseria gonorrhoeae: Current strategies and future directions. Drugs 81: 1153-1169. https://doi.org/10.1007/s40265-021-01530-0 ![]() |
[33] |
Johnson B (2023) GSK's gonorrhea vaccine receives fast-track designation to expedite clinical trials. Nature Med 29: 2146-2147. https://doi.org/10.1038/d41591-023-00069-9 ![]() |
[34] |
Scully IL, Timofeyeva Y, Illenberger A, et al. (2021) Performance of a four-antigen Staphylococcus aureus vaccine in preclinical models of invasive S. aureus disease. Microorg 15: 177. https://doi.org/10.3390/microorganisms9010177 ![]() |
[35] |
Madhi SA, Anderson AS, Absalon J, et al. (2023) Potential for maternally administered vaccine for infant Group B Streptococcus. N Engl J Med 389: 215-227. https://doi.org/10.1056/NEJMoa2116045 ![]() |
[36] |
Mahmoud A, Toth I, Stephenson R (2022) Developing an effective glycan-based vaccine for Streptococcus pyogenes. Angew Chem Int Ed 61. https://doi.org/10.1002/anie.202115342 ![]() |
[37] |
Smeesters PR, de Crombrugghe G, Tsoi SK, et al. (2024) Global Streptococcus pyogenes strain diversity, disease associations, and implications for vaccine development: A systematic review. Lancet Microbe 5: e181-e193. https://doi.org/10.1016/S2666-5247(23)00318-X ![]() |
[38] |
Walkinshaw DR, Wright MEE, Mullin AE, et al. (2023) The Streptococcus pyogenes vaccine landscape. npj Vaccines 8: 16. https://doi.org/10.1038/s41541-023-00609-x ![]() |
[39] |
Kojima N, Konda KA, Klausner JD (2022) Notes on syphilis vaccine development. Front Immunol 13: 952284. https://doi.org/10.3389/fimmu.2022.952284 ![]() |
[40] |
Noda AA, Méndez M, Rodríguez I, et al. (2022) Genetic recombination in treponema pallidum: implications for diagnosis, epidemiology, and vaccine development. Sex Transm Dis 49: e7-e10. https://doi.org/10.1097/OLQ.0000000000001497 ![]() |
[41] |
Scarpini S, Morigi F, Betti L, et al. (2021) Development of a vaccine against human cytomegalovirus: advances, barriers, and implications for the clinical practice. Vaccines 9: 551. https://doi.org/10.3390/vaccines9060551 ![]() |
[42] |
Schleiss MR, Diamond DJ (2020) Exciting times for cytomegalovirus (CMV) vaccine development: Navigating the pathways toward the goal of protecting infants against congenital CMV infection. Vaccines 8: 526. https://doi.org/10.3390/vaccines8030526 ![]() |
[43] |
Hu X, Wang HY, Otero CE, et al. (2022) Lessons from acquired natural immunity and clinical trials to inform next-generation human cytomegalovirus vaccine development. Ann Rev Vir 9: 491-520. https://doi.org/10.1146/annurev-virology-100220-010653 ![]() |
[44] |
Yechezkel I, Law M, Tzarum N (2021) From structural studies to HCV vaccine design. Viruses 13: 833. https://doi.org/10.3390/v13050833 ![]() |
[45] |
Malik S, Sah R, Ahsan O, et al. (2023) Insights into the novel therapeutics and vaccines against herpes simplex virus. Vaccines 11: 325. https://doi.org/10.3390/vaccines11020325 ![]() |
[46] |
Chentoufi A, Dhanushkodi NR, Srivastava R, et al. (2022) Combinatorial herpes simplex vaccine strategies: From bedside to bench and back. Front Immunol 13. https://doi.org/10.3389/fimmu.2022.849515 ![]() |
[47] |
Awasthi S, Friedman HM (2021) An mRNA vaccine to prevent genital herpes. Trans Res 242: 56-65. https://doi.org/10.1016/j.trsl.2021.12.006 ![]() |
[48] |
Stanfield BA, Kousoulas KG, Fernandez A, et al. (2021) Rational design of live-attenuated vaccines against herpes simplex viruses. Viruses 13: 1637. https://doi.org/10.3390/v13081637 ![]() |
[49] |
Ng'uni T, Chasara C, Ndhlovu ZM (2020) Major scientific hurdles in HIV vaccine development: historical perspective and future directions. Front Immunol 11: 590780. https://doi.org/10.3389/fimmu.2020.590780 ![]() |
[50] |
Nkolola JP, Barouch DH (2023) Prophylactic HIV-1 vaccine trials: past, present, and future. Lancet 11: E117-E124. https://doi.org/10.1016/S2352-3018(23)00264-3 ![]() |
[51] |
Schiffner T, Phung I, Ray R, et al. (2024) Vaccination induces broadly neutralizing antibody precursors to HIV gp41. Nat Immunol 25: 1073-1082. https://doi.org/10.1038/s41590-024-01833-w ![]() |
[52] |
Leggat DJ, Cohen KW, Willis JR, et al. (2022) Vaccination induces HIV broadly neutralizing antibody precursors in humans. Science 378: eadd6502. https://doi.org/10.1126/science.add6502 ![]() |
[53] |
Haynes BF, Wiehe K, Borrow P, et al. (2023) Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies. Nat Rev Immunol 23: 142-158. https://doi.org/10.1038/s41577-022-00753-w ![]() |
[54] |
Matarazzo L, Bettencourt PJG (2023) mRNA vaccines: a new opportunity for malaria, tuberculosis and HIV. Front Immunol 14. https://doi.org/10.3389/fimmu.2023.1172691 ![]() |
[55] |
Suzuki H, Noguchi T, Matsugu N, et al. (2022) Safety and immunogenicity of parvovirus B19 virus-like particle vaccine lacking phospholipase A2 activity. Vaccine 40: 6100-6106. https://doi.org/10.1016/j.vaccine.2022.09.009 ![]() |
[56] |
Zhang Y, Li D, Lu S, et al. (2022) Toxoplasmosis vaccines: what we have and where to go?. Npj Vaccines 7: 131. https://doi.org/10.1038/s41541-022-00563-0 ![]() |
[57] |
Wang Y, Ling L, Zhang Z, et al. (2022) Current advances in Zika vaccine development. Vaccines (Basel) 10: 1816. https://doi.org/10.3390/vaccines10111816 ![]() |
[58] |
Pielnaa P, Al-Saadawe M, Saro A, et al. (2020) Zika virus-spread, epidemiology, genome, transmission cycle, clinical manifestation, associated challenges, vaccine and antiviral drug development. Virology 543: 34-42. https://doi.org/10.1016/j.virol.2020.01.015 ![]() |
[59] |
Mordmüller B, Sulyok M, Egger-Adam D, et al. (2019) First-in-human, randomized, double-blind clinical trial of differentially adjuvanted PAMVAC, a vaccine candidate to prevent pregnancy-associated malaria. Clin Infect Dis 69: 1509-1516. https://doi.org/10.1093/cid/ciy1140 ![]() |
[60] |
Sirima SB, Richert L, Chêne A, et al. (2020) PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study. Lancet Infect Dis 20: 585-597. https://doi.org/10.1016/S1473-3099(19)30739-X ![]() |
[61] |
Kochhar S, Bonhoeffer J, Jones CE, et al. (2017) Immunization in pregnancy clinical research in low and middle income countries: study design, regulatory and safety considerations. Vaccine 35: 6575-6581. https://doi.org/10.1016/j.vaccine.2017.03.103 ![]() |
[62] | Centers for Disease Control and PreventionVaccine Adverse Event Reporting System (VAERS) (2021). Available from: https://vaers.hhs.gov/ |
[63] |
Healy SA, Fried M, Richie T, et al. (2019) Malaria vaccine trials in pregnant women: An imperative without precedent. Vaccine 37: 763-770. https://doi.org/10.1016/j.vaccine.2018.12.025 ![]() |
[64] | U.S. Food and Drug AdministrationFDA approves first vaccine for pregnant individuals to prevent rsv in infants (2023). Available from: https://www.fda.gov/news-events/press-announcements/fda-approves-first-vaccine-pregnant-individuals-prevent-rsv-infants |
[65] | Centers for Disease Control and PreventionCOVID-19 vaccines while pregnant or breastfeeding (2019). Available from: https://www.cdc.gov/coronavirus/2019-ncov/vaccines/recommendations/pregnancy.html |
[66] |
Badell ML, Dude CM, Rasmussen SA, et al. (2022) COVID-19 vaccination in pregnancy. BMJ 378: e069741. https://doi.org/10.1136/bmj-2021-069741 ![]() |
[67] |
Mitchell SL, Schulkin J, Power ML (2023) Vaccine hesitancy in pregnant women: A narrative review. Vaccine 41: 4220-4227. https://doi.org/10.1016/j.vaccine.2023.05.047 ![]() |
[68] |
Tuckerman J, Kaufman J, Danchin M (2022) Effective approaches to combat vaccine hesitancy. Pediatr Infect Dis J 41: e243-e245. https://doi.org/10.1097/INF.0000000000003499 ![]() |
[69] |
Kuehn M, LaMori J, DeMartino JK, et al. (2022) Assessing barriers to access and equity for COVID-19 vaccination in the US. BMC Public Health 22: 2263. https://doi.org/10.1186/s12889-022-14636-1 ![]() |
[70] |
Howard FHN, Kwan A, Winder N, et al. (2022) Understanding immune responses to viruses-do underlying Th1/Th2 cell biases predict outcome?. Viruses 14: 1493. https://doi.org/10.3390/v14071493 ![]() |
[71] |
Kim YH, Hong KJ, Kim H, et al. (2022) Influenza vaccines: past, present, and future. Rev Med Virol 32: e2243. https://doi.org/10.1002/rmv.2243 ![]() |
[72] |
Aleebrahim-Dehkordi E, Molavi B, Mokhtari M, et al. (2022) T helper type (Th1/Th2) responses to SARS-CoV-2 and influenza A (H1N1) virus: From cytokines produced to immune responses. Transpl Immunol 70: 101495. https://doi.org/10.1016/j.trim.2021.101495 ![]() |
[73] |
Rappuoli R, De Gregorio E, Costantino P (2018) On the mechanisms of conjugate vaccines. Proc Natl Acad Sci USA 116: 14-16. https://doi.org/10.1073/pnas.1819612116 ![]() |
[74] |
Sallusto F, Lanzavecchia A, Araki K, et al. (2010) From vaccines to memory and back. Immunity 33: 451-463. https://doi.org/10.1016/j.immuni.2010.10.008 ![]() |
[75] |
Siegrist CA (2008) Vaccine immunology. Vaccines 5: 17-36. https://doi.org/10.1016/B978-1-4160-3611-1.50006-4 ![]() |
[76] |
Wang Q, Tan MT, Keegan BP, et al. (2014) Time course study of the antigen-specific immune response to a PLGA microparticle vaccine formulation. Biomaterials 35: 8385-8393. https://doi.org/10.1016/j.biomaterials.2014.05.067 ![]() |
[77] |
Pyzik M, Kozicky LK, Gandhi AK, et al. (2023) The therapeutic age of the neonatal Fc receptor. Nat Rev Immunol 23: 415-432. https://doi.org/10.1038/s41577-022-00821-1 ![]() |
[78] |
Li Z, Palaniyandi S, Zeng R, et al. (2011) Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection. Proc Natl Acad Sci USA 108: 4388-4393. https://doi.org/10.1073/pnas.1012861108 ![]() |
[79] |
Palmeira P, Quinello C, Silveira-Lessa AL, et al. (2012) IgG placental transfer in healthy and pathological pregnancies. Clin Dev Immunol 2012: 985646. https://doi.org/10.1155/2012/985646 ![]() |
[80] | Li Y, Jin L, Chen T (2020) The effects of secretory IgA in the mucosal immune system. Biomed Res Int 2020: 2032057. https://doi.org/10.1155/2020/2032057 |
[81] |
Correa VA, Portilho AI, De Gaspari E (2022) Vaccines, adjuvants and key factors for mucosal immune response. Immunology 167: 124-138. https://doi.org/10.1111/imm.13526 ![]() |
[82] |
Mor G, Aldo P, Alvero A (2017) The unique immunological and microbial aspects of pregnancy. Nat Rev Immunol 17: 469-482. https://doi.org/10.1038/nri.2017.64 ![]() |
[83] |
Philbin VJ, Levy O (2009) Developmental biology of the innate immune response: implications for neonatal and infant vaccine development. Pediatr Res 65: 98R-105R. https://doi.org/10.1203/PDR.0b013e31819f195d ![]() |
[84] |
Basha S, Surendran N, Pichichero M (2014) Immune responses in neonates. Expert Rev Clin Immunol 10: 1171-1184. https://doi.org/10.1586/1744666X.2014.942288 ![]() |
[85] |
Whittaker E, Goldblatt D, McIntyre P, et al. (2018) Neonatal immunization: Rationale, current state, and future prospects. Front Immunol 9: 532. https://doi.org/10.3389/fimmu.2018.00532 ![]() |
[86] |
Semmes EC, Chen JL, Goswami R, et al. (2021) Understanding early-life adaptive immunity to guide interventions for pediatric health. Front Immunol 11. https://doi.org/10.3389/fimmu.2020.595297 ![]() |
[87] |
Apostol AC, Jensen KDC, Beaudin AE (2020) training the fetal immune system through maternal inflammation—A layered hygiene hypothesis. Front Immunol 11. https://doi.org/10.3389/fimmu.2020.00123 ![]() |
[88] |
Yu JC, Khodadadi H, Malik A, et al. (2018) Innate immunity of neonates and infants. Front Immunol 9: 1759. https://doi.org/10.3389/fimmu.2018.01759 ![]() |
[89] |
Megli CJ, Coyne CB (2022) Infections at the maternal–fetal interface: an overview of pathogenesis and defence. Nat Rev Microbiol 20: 67-82. https://doi.org/10.1038/s41579-021-00610-y ![]() |
[90] |
Camacho-Gonzalez A, Spearman PW, Stoll BJ (2013) Neonatal infectious diseases: evaluation of neonatal 9. Pediatr Clin North Am 60: 367-389. https://doi.org/10.1016/j.pcl.2012.12.003 ![]() |
[91] |
Atyeo C, Alter G (2021) The multifaceted roles of breast milk antibodies. Cell 184: 1486-1499. https://doi.org/10.1016/j.cell.2021.02.031 ![]() |
[92] |
Kumar M, Saadaoui M, Al Khodor S (2022) Infections and pregnancy: Effects on maternal and child health. Front Cell Infect Microbiol 12: 873253. https://doi.org/10.3389/fcimb.2022.873253 ![]() |
[93] |
Yockey LJ, Lucas C, Iwasaki A (2020) Contributions of maternal and fetal antiviral immunity in congenital disease. Science 368: 608-612. https://doi.org/10.1126/science.aaz1960 ![]() |
[94] |
Kwon S, Joshi AD, Lo CH, et al. (2021) Association of social distancing and face mask use with risk of COVID-19. Nat Commun 12: 3737. https://doi.org/10.1038/s41467-021-24115-7 ![]() |
[95] |
Mallory ML, Lindesmith LC, Baric RS (2018) Vaccination-induced herd immunity: Successes and challenges. J Allergy Clin Immunol 142: 64-66. https://doi.org/10.1016/j.jaci.2018.05.007 ![]() |
[96] |
Amaral E, Money D, Jamieson D, et al. (2023) Vaccination during pregnancy: A golden opportunity to embrace. Int J Gynecol Obstet 163: 476-483. https://doi.org/10.1002/ijgo.14981 ![]() |
[97] |
Gigi CE, Anumba DOC (2021) Parvovirus B19 infection in pregnancy-A review. Eur J Obstet Gynecol Reprod Biol 264: 358-362. https://doi.org/10.1016/j.ejogrb.2021.07.046 ![]() |
[98] |
Leruez-Ville M, Foulon I, Pass R, et al. (2020) Cytomegalovirus infection during pregnancy: state of the science. Am J Obstetrics Gynecology 223: 330-349. https://doi.org/10.1016/j.ajog.2020.02.018 ![]() |
[99] |
Pesch MH, Schleiss MR (2022) Emerging concepts in congenital cytomegalovirus. Pediatrics 150: e2021055896. https://doi.org/10.1542/peds.2021-055896 ![]() |
[100] |
Gerna G, Fornara C, Furione M, et al. (2021) Congenital human cytomegalovirus infection: A narrative review of maternal immune response and diagnosis in view of the development of a vaccine and prevention of primary and non-primary infections in pregnancy. Microorganisms 9: 1749. https://doi.org/10.3390/microorganisms9081749 ![]() |
[101] |
Marchant A, Sadarangani M, Garand M, et al. (2017) Maternal immunisation: collaborating with mother nature. Lancet Infect Dis 17: e197-e208. https://doi.org/10.1016/S1473-3099(17)30229-3 ![]() |
[102] | Immunization Action CoalitionVaccinations for pregnant women. Available from: https://www.immunize.org/nslt.d/n63/vacs_pregnant_women.pdf |
[103] |
Pollard AJ, Bijker EM (2021) A guide to vaccinology: From basic principles to new developments. Nat Rev Immunol 21: 83-100. https://doi.org/10.1038/s41577-020-00479-7 ![]() |
[104] | World Health OrganizationGuidelines for developing a national immunization strategy. Available from: https://iris.who.int/bitstream/handle/10665/351144/WHO-IVB-2021.05-eng.pdf |
[105] |
Slifka MK, Amanna IJ (2018) Passive immunization. Plotkin's Vaccines . Amsterdam: Elsevier Science 84-95. e10. https://doi.org/10.1016/B978-0-323-35761-6.00008-0 ![]() |
[106] |
Hammitt LL, Dagan R, Yuan Y, et al. (2022) Nirsevimab for prevention of RSV in healthy late-preterm and term infants. N Engl J Med 386: 837-846. https://doi.org/10.1056/NEJMoa2110275 ![]() |
[107] |
Terrault NA, Levy MT, Cheung KW, et al. (2021) Viral hepatitis and pregnancy. Nat Rev Gastroenterol Hepatol 18: 117-130. https://doi.org/10.1038/s41575-020-00361-w ![]() |
[108] | Lange C, Aaby P, Behr MA, et al. (2021) 100 years of Mycobacterium bovis bacille Calmette-Guérin. Lancet Infect Dis . https://doi.org/10.1016/S1473-3099(21)00403-5 |
[109] | WHONew TB Vaccine Research. Available from: https://www.who.int/teams/global-tuberculosis-programme/research-innovation/vaccines |
[110] |
Lai R, Ogunsola AF, Rakib T, et al. (2023) Key advances in vaccine development for tuberculosis—success and challenges. npj Vaccines 8: 158. https://doi.org/10.1038/s41541-023-00750-7 ![]() |
[111] | Hongmin K, Han-Gyu C, Sung Jae S (2023) Bridging the gaps to overcome major hurdles in the development of next-generation tuberculosis vaccines. Front Immunol 14. https://doi.org/10.3389/fimmu.2023.1193058 |
[112] | Concepcion F, Estivariz MD, Link-Gelles R, et al. (2021) Poliomyelitis. Centers for Disease Control and Prevention. Epidemiology and Prevention of Vaccine-Preventable Diseases. “The Pink Book” . Washington: D.C. Public Health Foundation. |
[113] |
O'Ryan M (2017) Rotavirus Vaccines: a story of success with challenges ahead. F1000Res 6: 1517. https://doi.org/10.12688/f1000research ![]() |
[114] |
Connolly SA, Jardetzky TS, Longnecker R (2021) The structural basis of herpesvirus entry. Nat Rev Microbiol 19: 110-121. https://doi.org/10.1038/s41579-020-00448-w ![]() |
[115] |
Ruckwardt TJ (2023) The road to approved vaccines for respiratory syncytial virus. npj Vaccines 8: 138. https://doi.org/10.1038/s41541-023-00734-7 ![]() |
[116] |
Barouch D (2022) COVID-19 vaccines—immunity, variants, boosters. N Engl J Med 387: 1011-1020. https://doi.org/10.1056/NEJMra2206573 ![]() |
[117] | Centers for Disease ControlVaccine Effectiveness: How Well Do Flu Vaccines Work?. Available from https://www.cdc.gov/flu/vaccines-work/vaccineeffect.htm |
[118] | Centers for Disease ControlSelecting Viruses for the Seasonal Influenza Vaccine. Available from: https://www.cdc.gov/flu/prevent/vaccine-selection.htm |
[119] | Centers for Disease Control.Use of an additional updated 2023–2024 covid-19 vaccine dose for adults aged ≥ 65 years: Recommendations of the advisory committee on immunization practices—united states, 2024. MMWR (2024) 73: 377-381. https://doi.org/10.15585/mmwr.mm7316a4 |
[120] |
Masomian M, Ahmad Z, Gew LT, et al. (2020) Development of next generation Streptococcus pneumoniae vaccines conferring broad protection. Vaccines 8: 132. https://doi.org/10.3390/vaccines8010132 ![]() |
[121] |
Li S, Liang H, Zhao SH, et al. (2023) Recent progress in pneumococcal protein vaccines. Front Immunol 14: 1278346. https://doi.org/10.3389/fimmu.2023.1278346 ![]() |
[122] |
Dhama K, Dhawan M, Tiwari R, et al. (2022) COVID-19 intranasal vaccines: current progress, advantages, prospects, and challenges. Hum Vaccin Immunother 18: 2045853. https://doi.org/10.1080/21645515.2022.2045853 ![]() |
[123] |
Salloum M, Paviotti A, Bastiaens H, et al. (2023) The inclusion of pregnant women in vaccine clinical trials: An overview of late-stage clinical trials' records between 2018 and 2023. Vaccine 41: 7076-7083. https://doi.org/10.1016/j.vaccine.2023.10.057 ![]() |
[124] |
Matić Z, Šantak M (2022) Current view on novel vaccine technologies to combat human infectious diseases. Appl Microbiol Biotechnol 106: 25-56. https://doi.org/10.1007/s00253-021-11713-0 ![]() |
[125] |
Zhao T, Cai Y, Jiang Y, et al. (2023) Vaccine adjuvants: mechanisms and platforms. Sig Transduct Target Ther 8: 283. https://doi.org/10.1038/s41392-023-01557-7 ![]() |
[126] |
Rzymski P, Szuster-Ciesielska A, Dzieciątkowski T, et al. (2023) mRNA vaccines: The future of prevention of viral infections?. J Med Virol 95: e28572. https://doi.org/10.1002/jmv.28572 ![]() |
[127] |
Nagashima KA, Mousa JJ (2021) Next-generation influenza HA immunogens and adjuvants in pursuit of a broadly protective vaccine. Viruses 13: 546. https://doi.org/10.3390/v13040546 ![]() |
[128] |
Rappuoli R, Bottomley MJ, D'Oro U, et al. (2016) Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design. J Exp Med 213: 469-481. https://doi.org/10.1084/jem.20151960 ![]() |
[129] |
Pagliari S, Dema B, Sanchez-Martinez A, et al. (2023) DNA vaccines: history, molecular mechanisms and future perspectives. J Mol Biol 435: 168297. https://doi.org/10.1016/j.jmb.2023.168297 ![]() |
[130] |
Slütter B, Jiskoot W (2016) Sizing the optimal dimensions of a vaccine delivery system: a particulate matter. Expert Opin Drug Deliv 13: 167-170. https://doi.org/10.1517/17425247.2016.1121989 ![]() |
[131] |
Facciolà A, Visalli G, Laganà A, et al. (2022) An overview of vaccine adjuvants: Current evidence and future perspectives. Vaccines 10: 819. https://doi.org/10.3390/vaccines10050819 ![]() |
[132] |
Nesbitt RC, Asilaza VK, Gignoux E, et al. (2024) Vaccination coverage and adverse events following a reactive vaccination campaign against hepatitis E in Bentiu displaced persons camp, South Sudan. PLoS Negl Trop Dis 18: e0011661. https://doi.org/10.1371/journal.pntd.0011661 ![]() |
[133] |
Gigi CE, Anumba DOC (2021) Parvovirus B19 infection in pregnancy-A review. Eur J Obstet Gynecol Reprod Biol 264: 358-362. https://doi.org/10.1016/j.ejogrb.2021.07.046 ![]() |
[134] |
Dittmer FP, Guimarães CM, Peixoto AB, et al. (2024) Parvovirus B19 infection and pregnancy: Review of the current knowledge. J Pers Med 14: 139. https://doi.org/10.3390/jpm14020139 ![]() |
[135] |
Sartori P, Egloff C, Hcini N, et al. (2023) Primary, secondary, and tertiary prevention of congenital cytomegalovirus infection. Viruses 15: 819. https://doi.org/10.3390/v15040819 ![]() |
[136] |
Adugna A (2023) Therapeutic strategies and promising vaccine for hepatitis C virus infection. Immun Inflamm Dis 11: e977. https://doi.org/10.1002/iid3.977 ![]() |
[137] |
Fuerst TR, Pierce BG, Keck ZY, et al. (2018) Designing a B cell-based vaccine against a highly variable hepatitis C virus. Front Microbiol 8. https://doi.org/10.3389/fmicb.2017.02692 ![]() |
[138] |
Zhao Q, He K, Zhang X, et al. (2022) Production and immunogenicity of different prophylactic vaccines for hepatitis C virus (Review). Exp Ther Med 24: 474. https://doi.org/10.3892/etm.2022.11401 ![]() |
1. | F. Parrinello, G. Borino, Non associative damage interface model for mixed mode delamination and frictional contact, 2019, 76, 09977538, 108, 10.1016/j.euromechsol.2019.03.012 | |
2. | Francesco Parrinello, Vincenzo Gulizzi, Ivano Benedetti, A Model for Low-Cycle Fatigue in Micro-Structured Materials, 2019, 827, 1662-9795, 134, 10.4028/www.scientific.net/KEM.827.134 | |
3. | Francesco Parrinello, Hybrid equilibrium element with interelement interface for the analysis of delamination and crack propagation problems, 2021, 122, 0029-5981, 190, 10.1002/nme.6531 | |
4. | Francesco Parrinello, Guido Borino, 2020, Chapter 35, 978-3-030-41056-8, 419, 10.1007/978-3-030-41057-5_35 | |
5. | Francesco Parrinello, Guido Borino, An extrinsic interface developed in an equilibrium based finite element formulation, 2019, 18, 24523216, 616, 10.1016/j.prostr.2019.08.207 | |
6. | Francesco Parrinello, Hybrid Equilibrium Finite Element Formulation for Cohesive Crack Propagation, 2019, 827, 1662-9795, 104, 10.4028/www.scientific.net/KEM.827.104 | |
7. | F. Parrinello, I. Benedetti, A coupled plasticity-damage cohesive-frictional interface for low-cycle fatigue analysis, 2022, 224, 00207403, 107298, 10.1016/j.ijmecsci.2022.107298 | |
8. | Aazim Shafi Lone, G. A. Harmain, Azher Jameel, Modeling of contact interfaces by penalty based enriched finite element method, 2022, 1537-6494, 1, 10.1080/15376494.2022.2034075 | |
9. | András Szekrényes, Differential quadrature solution for composite flat plates with delamination using higher-order layerwise models, 2022, 248, 00207683, 111621, 10.1016/j.ijsolstr.2022.111621 | |
10. | András Szekrényes, Application of differential quadrature method to delaminated first-order shear deformable composite plates, 2021, 166, 02638231, 108028, 10.1016/j.tws.2021.108028 | |
11. | Guido Borino, Francesco Parrinello, A symmetric tangent stiffness approach to cohesive mechanical interfaces in large displacements, 2022, 23, 1550-2287, 551, 10.1080/15502287.2022.2032481 |
Specimen number | Fracture energy GII [N/mm] |
1 | 0.4706 |
2 | 0.4737 |
3 | 0.4198 |
4 | 0.4481 |
Mean value | 0.4531 |