Dysbiosis, small intestinal bacterial overgrowth and biofilms in autism and chronic illness

Anju Usman Singh; Anju Usman Singh

doi:10.3934/molsci.2018.2.160

AIMS Molecular Science

2018, Volume 5, Issue 2: 160-165. doi: 10.3934/molsci.2018.2.160

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Dysbiosis, small intestinal bacterial overgrowth and biofilms in autism and chronic illness

Anju Usman Singh ^,

True Health Medical Center, 603 E Diehl Rd, Suite 135, Naperville, IL 60563, USA

Received: 28 February 2018 Accepted: 22 May 2018 Published: 07 June 2018

Recent evidences highlight that alteration of gut microbiota homeostasis could trigger several human pathologies, among them autism spectrum disorders (ASD). This short hypothesis article summarizes the recent literature and offers a novel, complementary and biomedical drugs/natural agents-combined therapy for treating gastrointestinal issues and microbial biofilms in ASD and chronic illness.
- autism,
- gut brain axis,
- gastrointestinal symptoms,
- biofilms,
- SIBO
Citation: Anju Usman Singh. Dysbiosis, small intestinal bacterial overgrowth and biofilms in autism and chronic illness[J]. AIMS Molecular Science, 2018, 5(2): 160-165. doi: 10.3934/molsci.2018.2.160

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Abstract

Recent evidences highlight that alteration of gut microbiota homeostasis could trigger several human pathologies, among them autism spectrum disorders (ASD). This short hypothesis article summarizes the recent literature and offers a novel, complementary and biomedical drugs/natural agents-combined therapy for treating gastrointestinal issues and microbial biofilms in ASD and chronic illness.

References

[1]	Cryan JF, Dinan TG (2012) Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 13: 701–712. doi: 10.1038/nrn3346
[2]	Borre YE, Moloney RD, Clarke G, et al. (2014) The impact of microbiota on brain and behavior: Mechanisms & therapeutic potential. Adv Exp Med Biol 817: 373–403. doi: 10.1007/978-1-4939-0897-4_17
[3]	Diagnostic and Statistical Manual of Mental Disorders (DSM-V), 2013. American Psychiatric Association, 189: 4189.
[4]	Siniscalco D, Cirillo A, Bradstreet JJ, et al. (2013) Epigenetic findings in autism: New perspectives for therapy. Int J Environ Res Public Health 10: 4261–4273. doi: 10.3390/ijerph10094261
[5]	Frye RE, Slattery J, Macfabe DF, et al. (2015) Approaches to studying and manipulating the enteric microbiome to improve autism symptoms. Microb Ecol Health Dis 26: 26878.
[6]	De Magistris L, Picardi A, Siniscalco D, et al. (2013) Antibodies against food antigens in patients with autistic spectrum disorders. BioMed Res Int 2013: 729349.
[7]	Mcelhanon BO, Mccracken C, Karpen S, et al. (2014) Gastrointestinal symptoms in autism spectrum disorder: A meta-analysis. Pediatrics 133: 872–883. doi: 10.1542/peds.2013-3995
[8]	Adams JB, Johansen LJ, Powell LD, et al. (2011) Gastrointestinal flora and gastrointestinal status in children with autism-comparisons to typical children and correlation with autism severity. BMC Gastroenterol 11: 22. doi: 10.1186/1471-230X-11-22
[9]	Nikolov RN, Bearss KE, Lettinga J, et al. (2009) Gastrointestinal symptoms in a sample of children with pervasive developmental disorders. J Autism Dev Disord 39: 405–413. doi: 10.1007/s10803-008-0637-8
[10]	Iovene MR, Bombace F, Maresca R, et al. (2017) Intestinal dysbiosis and Yeast Isolation in Stool of Subjects with Autism Spectrum Disorders. Mycopathologia 182: 349–363. doi: 10.1007/s11046-016-0068-6
[11]	Siniscalco D (2014) Gut bacteria-brain axis in autism. Autism 4: e124.
[12]	Kranich J, Maslowski KM, Mackay CR (2011) Commensal flora and the regulation of inflammatory and autoimmune responses. Semin Immunol 23: 139–145. doi: 10.1016/j.smim.2011.01.011
[13]	Macfarlane S, Macfarlane GT (2006) Composition and metabolic activities of bacterial biofilms colonizing food residues in the human gut. Appl Environ Microbiol 72: 6204–6211. doi: 10.1128/AEM.00754-06
[14]	Liu Y, Fatheree NY, Mangalat N, et al. (2010) Human-derived probiotic Lactobacillus reuteri strains differentially reduce intestinal inflammation. Am J Physiol Gastrointest Liver Physiol 299: G1087–G1096. doi: 10.1152/ajpgi.00124.2010
[15]	Fateh R, Iravani S, Frootan M, et al. (2011) Synbiotic preparation in men suffering from functional constipation: A randomised controlled trial. Swiss Med Wkly 141: w13239.
[16]	Vuong HE, Hsiao EY (2017) Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder. Biol Psychiatry 81: 411–423. doi: 10.1016/j.biopsych.2016.08.024
[17]	Strati F, Cavalieri D, Albanese D, et al. (2017) New evidences on the altered gut microbiota in autism spectrum disorders. Microbiome 5: 24. doi: 10.1186/s40168-017-0242-1
[18]	Finegold SM, Molitoris D, Song Y, et al. (2002) Gastrointestinal microflora studies in late-onset autism. Clin Infect Dis 35: S6–S16. doi: 10.1086/341914
[19]	Wang L, Christophersen CT, Sorich MJ, et al. (2013) Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorder. Mol Autism 4: 42.
[20]	Williams BL, Hornig M, Parekh T, et al. (2012) Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances. MBio 3: 54–64.
[21]	Kang DW, Park JG, Ilhan ZE, et al. (2013) Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children. PLoS One 8: e68322. doi: 10.1371/journal.pone.0068322
[22]	Ding HT, Taur Y, Walkup JT (2017) Gut microbiota and autism: Key concepts and findings. J Autism Dev Disord 47: 480–489. doi: 10.1007/s10803-016-2960-9
[23]	Frye RE, Nankova B, Bhattacharyya S, et al. (2017) Modulation of immunological pathways in autistic and neurotypical lymphoblastoid cell lines by the enteric microbiome metabolite propionic acid. Front Immunol 8: 1670. doi: 10.3389/fimmu.2017.01670
[24]	Shaw W (2010) Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophrenia. Nutr Neurosci 13: 135–143.
[25]	Wang L, Yu YM, Zhang YQ, et al. (2018) Hydrogen breath test to detect small intestinal bacterial overgrowth: A prevalence case-control study in autism. Eur Child Adolesc Psychiatry 27: 233–240. doi: 10.1007/s00787-017-1039-2
[26]	Adike A, DiBaise JK (2018) Small Intestinal Bacterial Overgrowth: Nutritional Implications, Diagnosis, and Management. Gastroenterol Clin North Am 47: 193–208. doi: 10.1016/j.gtc.2017.09.008
[27]	House SA, Goodman DC, Weinstein SJ, et al. (2016) Prescription use among children with autism spectrum disorders in Northern New England: Intensity and small area variation. J Pediatr 169: 277–283. doi: 10.1016/j.jpeds.2015.10.027
[28]	Rana SV, Bhardwaj SB (2008) Small intestinal bacterial overgrowth. Scand J Gastroenterol 43: 1030–1037. doi: 10.1080/00365520801947074
[29]	Quera PR, Quigley EM, Madrid SAM (2005) Small intestinal bacterial overgrowth. An update. Rev Med Chile 133: 1361–1370.
[30]	Gatta L, Scarpignato C (2017) Systematic review with meta-analysis: Rifaximin is effective and safe for the treatment of small intestine bacterial overgrowth. Aliment Pharmacol Ther 45: 604–616. doi: 10.1111/apt.13928
[31]	Kwiatkowski L, Rice E, Langland J (2017) Integrative treatment of chronic abdominal bloating and pain associated with overgrowth of small intestinal bacteria: A case report. Altern Ther Health Med 23: 56–61.
[32]	Kernien JF, Snarr BD, Sheppard DC, et al. (2018) The interface between fungal biofilms and innate immunity. Front Immunol 8: 1968. doi: 10.3389/fimmu.2017.01968
[33]	Anwar H, Dasgupta MK, Costerton JW (1990) Testing the susceptibility of bacteria in biofilms to antibacterial agents. Antimicrob Agents Chemother 34: 2043–2046. doi: 10.1128/AAC.34.11.2043
[34]	Høiby N, Bjarnsholt T, Moser C, et al. (2015) ESCMID guideline for the diagnosis and treatment of biofilm infections 2014. Clin Microbiol Infect 1: 1–25.
[35]	Smith A, Buchinsky FJ, Post JC (2011) Eradicating chronic ear, nose, and throat infections: A systematically conducted literature review of advances in biofilm treatment. Otolaryngol Head Neck Surg 144: 338–347. doi: 10.1177/0194599810391620
[36]	Slobodníková L, Fialová S, Rendeková K, et al. (2016) Antibiofilm activity of plant polyphenols. Molecules 21: 1717. doi: 10.3390/molecules21121717
[37]	Li XH, Lee JH (2017) Antibiofilm agents: A new perspective for antimicrobial strategy. J Microbiol 55: 753–766. doi: 10.1007/s12275-017-7274-x
[38]	de Magistris L, Familiari V, Pascotto A, et al. (2010) Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives. J Pediatr Gastroenterol Nutr 51: 418–424. doi: 10.1097/MPG.0b013e3181dcc4a5
[39]	Wan MLY, Ling KH, El-Nezami H, et al. (2018) Influence of functional food components on gut health. Crit Rev Food Sci Nutr 2018: 1–10.
[40]	Laparra JM, Sanz Y (2010) Interactions of gut microbiota with functional food components and nutraceuticals. Pharmacol Res 61: 219–225. doi: 10.1016/j.phrs.2009.11.001

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