Review

Saccharomyces cerevisiae and its industrial applications

  • These two authors contributed equally
  • Received: 13 September 2019 Accepted: 19 January 2020 Published: 11 February 2020
  • Saccharomyces cerevisiae is the best studied eukaryote and a valuable tool for most aspects of basic research on eukaryotic organisms. This is due to its unicellular nature, which often simplifies matters, offering the combination of the facts that nearly all biological functions found in eukaryotes are also present and well conserved in S. cerevisiae. In addition, it is also easily amenable to genetic manipulation. Moreover, unlike other model organisms, S. cerevisiae is concomitantly of great importance for various biotechnological applications, some of which date back to several thousands of years. S. cerevisiae's biotechnological usefulness resides in its unique biological characteristics, i.e., its fermentation capacity, accompanied by the production of alcohol and CO2 and its resilience to adverse conditions of osmolarity and low pH. Among the most prominent applications involving the use of S. cerevisiae are the ones in food, beverage -especially wine- and biofuel production industries. This review focuses exactly on the function of S. cerevisiae in these applications, alone or in conjunction with other useful microorganisms involved in these processes. Furthermore, various aspects of the potential of the reservoir of wild, environmental, S. cerevisiae isolates are examined under the perspective of their use for such applications.

    Citation: Maria Parapouli, Anastasios Vasileiadis, Amalia-Sofia Afendra, Efstathios Hatziloukas. Saccharomyces cerevisiae and its industrial applications[J]. AIMS Microbiology, 2020, 6(1): 1-31. doi: 10.3934/microbiol.2020001

    Related Papers:

  • Saccharomyces cerevisiae is the best studied eukaryote and a valuable tool for most aspects of basic research on eukaryotic organisms. This is due to its unicellular nature, which often simplifies matters, offering the combination of the facts that nearly all biological functions found in eukaryotes are also present and well conserved in S. cerevisiae. In addition, it is also easily amenable to genetic manipulation. Moreover, unlike other model organisms, S. cerevisiae is concomitantly of great importance for various biotechnological applications, some of which date back to several thousands of years. S. cerevisiae's biotechnological usefulness resides in its unique biological characteristics, i.e., its fermentation capacity, accompanied by the production of alcohol and CO2 and its resilience to adverse conditions of osmolarity and low pH. Among the most prominent applications involving the use of S. cerevisiae are the ones in food, beverage -especially wine- and biofuel production industries. This review focuses exactly on the function of S. cerevisiae in these applications, alone or in conjunction with other useful microorganisms involved in these processes. Furthermore, various aspects of the potential of the reservoir of wild, environmental, S. cerevisiae isolates are examined under the perspective of their use for such applications.


    加载中


    Conflict of interest



    All authors declare no conflicts of interest in this paper.

    [1] Goffeau A, Barrell BG, Bussey H, et al. (1996) Life with 6000 genes. Science 274: 563-547. doi: 10.1126/science.274.5287.546
    [2] Wood V, Rutherford KM, Ivens A, et al. (2001) A re-annotation of the Saccharomyces cerevisiae genome. Comp Funct Genomics 2: 143-154. doi: 10.1002/cfg.86
    [3] Doolittle WF (1999) Lateral genomics. Trends Cell Biol 9: M5-8. doi: 10.1016/S0962-8924(99)01664-5
    [4] Hall C, Brachat S, Dietrich FS (2005) Contribution of horizontal gene transfer to the evolution of Saccharomyces cerevisiaeEukaryot Cell 4: 1102-1115. doi: 10.1128/EC.4.6.1102-1115.2005
    [5] Galeote V, Novo M, Salema-Oom M, et al. (2010) FSY1, a horizontally transferred gene in the Saccharomyces cerevisiae EC1118 wine yeast strain, encodes a high-affinity fructose/H+ symporter. Microbiology 156: 3754-3761. doi: 10.1099/mic.0.041673-0
    [6] de Zamaroczy M, Bernardi G (1985) Sequence organization of the mitochondrial genome of yeast--a review. Gene 37: 1-17. doi: 10.1016/0378-1119(85)90252-5
    [7] Foury F, Roganti T, Lecrenier N, et al. (1998) The complete sequence of the mitochondrial genome of Saccharomyces cerevisiaeFEBS Lett 440: 325-331. doi: 10.1016/S0014-5793(98)01467-7
    [8] Futcher AB (1988) The 2 micron circle plasmid of Saccharomyces cerevisiaeYeast 4: 27-40. doi: 10.1002/yea.320040104
    [9] Wickner RB (1996) Double-stranded RNA viruses of Saccharomyces cerevisiaeMicrobiol Rev 60: 250-265. doi: 10.1128/MMBR.60.1.250-265.1996
    [10] Thomson JM, Gaucher EA, Burgan MF, et al. (2005) Resurrecting ancestral alcohol dehydrogenases from yeast. Nat Genet 37: 630-635. doi: 10.1038/ng1553
    [11] Pronk JT, Yde Steensma H, Van Dijken JP (1996) Pyruvate metabolism in Saccharomyces cerevisiaeYeast 12: 1607-1633. doi: 10.1002/(SICI)1097-0061(199612)12:16<1607::AID-YEA70>3.0.CO;2-4
    [12] Hagman A, Sall T, Compagno C, et al. (2013) Yeast ‘make-accumulate-consume’ life strategy evolved as a multi-step process that predates the whole genome duplication. PLoS One 8: e68734. doi: 10.1371/journal.pone.0068734
    [13] Wolfe KH, Shields DC (1997) Molecular evidence for an ancient duplication of the entire yeast genome. Nature 387: 708-713. doi: 10.1038/42711
    [14] Ihmels J, Bergmann S, Gerami-Nejad M, et al. (2005) Rewiring of the yeast transcriptional network through the evolution of motif usage. Science 309: 938-940. doi: 10.1126/science.1113833
    [15] Rozpedowska E, Hellborg L, Ishchuk OP, et al. (2011) Parallel evolution of the make-accumulate-consume strategy in Saccharomyces and Dekkera yeasts. Nat Commun 2: 302. doi: 10.1038/ncomms1305
    [16] Mortimer R, Polsinelli M (1999) On the origins of wine yeast. Res Microbiol 150: 199-204. doi: 10.1016/S0923-2508(99)80036-9
    [17] Taylor MW, Tsai P, Anfang N, et al. (2014) Pyrosequencing reveals regional differences in fruit-associated fungal communities. Environ Microbiol 16: 2848-2858. doi: 10.1111/1462-2920.12456
    [18] Stefanini I, Dapporto L, Legras JL, et al. (2012) Role of social wasps in Saccharomyces cerevisiae ecology and evolution. Proc Natl Acad Sci USA 109: 13398-13403. doi: 10.1073/pnas.1208362109
    [19] Buser CC, Newcomb RD, Gaskett AC, et al. (2014) Niche construction initiates the evolution of mutualistic interactions. Ecol Lett 17: 1257-1264. doi: 10.1111/ele.12331
    [20] Wang QM, Liu WQ, Liti G, et al. (2012) Surprisingly diverged populations of Saccharomyces cerevisiae in natural environments remote from human activity. Mol Ecol 21: 5404-5417. doi: 10.1111/j.1365-294X.2012.05732.x
    [21] Camarasa C, Sanchez I, Brial P, et al. (2011) Phenotypic landscape of Saccharomyces cerevisiae during wine fermentation: evidence for origin-dependent metabolic traits. PLoS One 6: e25147. doi: 10.1371/journal.pone.0025147
    [22] Stewart GG (2014) SACCHAROMYCES | Saccharomyces cerevisiaeEncyclopedia of Food Microbiology (Second Edition) Oxford: Academic Press, 309-315. doi: 10.1016/B978-0-12-384730-0.00292-5
    [23] Hittinger CT, Steele JL, Ryder DS (2018) Diverse yeasts for diverse fermented beverages and foods. Curr Opin Biotechnol 49: 199-206. doi: 10.1016/j.copbio.2017.10.004
    [24] McGovern PE, Glusker DL, Exner LJ, et al. (1996) Neolithic resinated wine. Nature 381: 480. doi: 10.1038/381480a0
    [25] Cavalieri D, McGovern PE, Hartl DL, et al. (2003) Evidence for S. cerevisiae fermentation in ancient wine. J Mol Evol 57 Suppl 1: S226-232. doi: 10.1007/s00239-003-0031-2
    [26] Pasteur L (1860)  Mémoire sur la fermentation alcoolique Mallet-Bachelier.
    [27] Marsit S, Dequin S (2015) Diversity and adaptive evolution of Saccharomyces wine yeast: a review. FEMS Yeast Res 15: fov067. doi: 10.1093/femsyr/fov067
    [28] Bauer F, Pretorius IS (2000) Yeast stress response and fermentation efficiency: how to survive the making of wine-a review. S Afr J Enol Vitic 21: 27-51.
    [29] Eldarov MA, Kishkovskaia SA, Tanaschuk TN, et al. (2016) Genomics and biochemistry of Saccharomyces cerevisiae wine yeast strains. Biochemistry (Mosc) 81: 1650-1668. doi: 10.1134/S0006297916130046
    [30] Swiegers JH, Saerens SM, Pretorius IS (2016) Novel yeast strains as tools for adjusting the flavor of fermented beverages to market specifications. Biotechnol Flavor Prod 62-132. doi: 10.1002/9781118354056.ch3
    [31] Matallana E, Aranda A (2017) Biotechnological impact of stress response on wine yeast. Lett Appl Microbiol 64: 103-110. doi: 10.1111/lam.12677
    [32] Mina M, Tsaltas D (2017) Contribution of yeast in wine aroma and flavour. Yeast - industrial applications .
    [33] Cordente AG, Curtin CD, Varela C, et al. (2012) Flavour-active wine yeasts. Appl Microbiol Biotechnol 96: 601-618. doi: 10.1007/s00253-012-4370-z
    [34] Ehrlich F (1907) Über die Bedingungen der Fuselölbildung und über ihren Zusammenhang mit dem Eiweißaufbau der Hefe. Berichte der deutschen chemischen Gesellschaft 40: 1027-1047. doi: 10.1002/cber.190704001156
    [35] Hazelwood LA, Daran JM, van Maris AJ, et al. (2008) The Ehrlich pathway for fusel alcohol production: a century of research on Saccharomyces cerevisiae metabolism. Appl Environ Microbiol 74: 2259-2266. doi: 10.1128/AEM.02625-07
    [36] Styger G, Jacobson D, Bauer FF (2011) Identifying genes that impact on aroma profiles produced by Saccharomyces cerevisiae and the production of higher alcohols. Appl Microbiol Biotechnol 91: 713-730. doi: 10.1007/s00253-011-3237-z
    [37] Styger G, Jacobson D, Prior BA, et al. (2013) Genetic analysis of the metabolic pathways responsible for aroma metabolite production by Saccharomyces cerevisiaeAppl Microbiol Biotechnol 97: 4429-4442. doi: 10.1007/s00253-012-4522-1
    [38] Swiegers JH, Pretorius IS (2005) Yeast modulation of wine flavor. Adv Appl Microbiol 57: 131-175. doi: 10.1016/S0065-2164(05)57005-9
    [39] Ugliano MA, Henschke P, Herderich M, et al. (2007) Nitrogen management is critical for wine flavour and style. Aust N Z Wine Ind J 22: 24-30.
    [40] Vilanova M, Pretorius IS, Henschke PA (2015) Influence of diammonium phosphate addition to fermentation on wine biologicals. Processing and impact on active components in Food San Diego: Academic Press, 483-491. doi: 10.1016/B978-0-12-404699-3.00058-5
    [41] Carrau FM, Medina K, Farina L, et al. (2008) Production of fermentation aroma compounds by Saccharomyces cerevisiae wine yeasts: effects of yeast assimilable nitrogen on two model strains. FEMS Yeast Res 8: 1196-1207. doi: 10.1111/j.1567-1364.2008.00412.x
    [42] Verstrepen KJ, Van Laere SD, Vanderhaegen BM, et al. (2003) Expression levels of the yeast alcohol acetyltransferase genes ATF1, Lg-ATF1, and ATF2 control the formation of a broad range of volatile esters. Appl Environ Microbiol 69: 5228-5237. doi: 10.1128/AEM.69.9.5228-5237.2003
    [43] Lambrechts MG, Pretorius IS (2000) Yeast and its importance to wine aroma—A Review. S Afri J Enology Viti 21: 97-129.
    [44] Ruiz J, Kiene F, Belda I, et al. (2019) Effects on varietal aromas during wine making: a review of the impact of varietal aromas on the flavor of wine. Appl Microbiol Biotechnol 103: 7425-7450. doi: 10.1007/s00253-019-10008-9
    [45] Saerens SM, Delvaux FR, Verstrepen KJ, et al. (2010) Production and biological function of volatile esters in Saccharomyces cerevisiaeMicrob Biotechnol 3: 165-177. doi: 10.1111/j.1751-7915.2009.00106.x
    [46] Mason AB, Dufour JP (2000) Alcohol acetyltransferases and the significance of ester synthesis in yeast. Yeast 16: 1287-1298. doi: 10.1002/1097-0061(200010)16:14<1287::AID-YEA613>3.0.CO;2-I
    [47] Lilly M, Lambrechts MG, Pretorius IS (2000) Effect of increased yeast alcohol acetyltransferase activity on flavor profiles of wine and distillates. Appl Environ Microbiol 66: 744-753. doi: 10.1128/AEM.66.2.744-753.2000
    [48] Lilly M, Bauer FF, Lambrechts MG, et al. (2006) The effect of increased yeast alcohol acetyltransferase and esterase activity on the flavour profiles of wine and distillates. Yeast 23: 641-659. doi: 10.1002/yea.1382
    [49] Kruis AJ, Levisson M, Mars AE, et al. (2017) Ethyl acetate production by the elusive alcohol acetyltransferase from yeast. Metab Eng 41: 92-101. doi: 10.1016/j.ymben.2017.03.004
    [50] Kruis AJ, Gallone B, Jonker T, et al. (2018) Contribution of Eat1 and Other Alcohol Acyltransferases to Ester Production in Saccharomyces cerevisiaeFront Microbiol 9: 3202. doi: 10.3389/fmicb.2018.03202
    [51] Saerens SM, Verstrepen KJ, Van Laere SD, et al. (2006) The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity. J Biol Chem 281: 4446-4456. doi: 10.1074/jbc.M512028200
    [52] Fukuda K, Kuwahata O, Kiyokawa Y, et al. (1996) Molecular cloning and nucleotide sequence of the isoamyl acetate-hydrolyzing esterase gene (EST2) from Saccharomyces cerevisiaeJ Ferment Bioeng 82: 8-15. doi: 10.1016/0922-338X(96)89447-5
    [53] Fukuda K, Yamamoto N, Kiyokawa Y, et al. (1998) Balance of activities of alcohol acetyltransferase and esterase in Saccharomyces cerevisiae is important for production of isoamyl acetate. Appl Environ Microbiol 64: 4076-4078. doi: 10.1128/AEM.64.10.4076-4078.1998
    [54] Liu S-Q, Pilone GJ (2000) An overview of formation and roles of acetaldehyde in winemaking with emphasis on microbiological implications. Int J Food Sci Technol 35: 49-61. doi: 10.1046/j.1365-2621.2000.00341.x
    [55] Styger G, Prior B, Bauer FF (2011) Wine flavor and aroma. J Ind Microbiol Biotechnol 38: 1145-1159. doi: 10.1007/s10295-011-1018-4
    [56] de Assis LJ, Zingali RB, Masuda CA, et al. (2013) Pyruvate decarboxylase activity is regulated by the Ser/Thr protein phosphatase Sit4p in the yeast Saccharomyces cerevisiaeFEMS Yeast Res 13: 518-528. doi: 10.1111/1567-1364.12052
    [57] Eglinton J, Griesser M, Henschke P, et al. (2004) Yeast-mediated formation of pigmented polymers in red wine. Red wine color American Chemical Society, 7-21. doi: 10.1021/bk-2004-0886.ch002
    [58] Klosowski G, Mikulski D, Rolbiecka A, et al. (2017) Changes in the concentration of carbonyl compounds during the alcoholic fermentation process carried out with Saccharomyces cerevisiae yeast. Pol J Microbiol 66: 327-334. doi: 10.5604/01.3001.0010.4861
    [59] Romano P, Suzzi G, Turbanti L, et al. (1994) Acetaldehyde production in Saccharomyces cerevisiae wine yeasts. FEMS Microbiol Lett 118: 213-218. doi: 10.1111/j.1574-6968.1994.tb06830.x
    [60] Schuller D, Casal M (2005) The use of genetically modified Saccharomyces cerevisiae strains in the wine industry. Appl Microbiol Biotechnol 68: 292-304. doi: 10.1007/s00253-005-1994-2
    [61] Scacco A, Oliva D, Di Maio S, et al. (2012) Indigenous Saccharomyces cerevisiae strains and their influence on the quality of Cataratto, Inzolia and Grillo white wines. Food Res Int 46: 1-9. doi: 10.1016/j.foodres.2011.10.038
    [62] Alves Z, Melo A, Figueiredo AR, et al. (2015) Exploring the Saccharomyces cerevisiae volatile metabolome: indigenous versus commercial strains. PLoS One 10: e0143641. doi: 10.1371/journal.pone.0143641
    [63] Álvarez-Pérez JM, Álvarez-Rodríguez ML, Campo E, et al. (2016) Selection of Saccharomyces cerevisiae strains applied to the production of Prieto Picudo Rosé wines with a different aromatic profile. S Afri J Enology Viti 35: 15.
    [64] Tufariello M, Chiriatti MA, Grieco F, et al. (2014) Influence of autochthonous Saccharomyces cerevisiae strains on volatile profile of Negroamaro wines. LWT - Food Sci Technol 58: 35-48. doi: 10.1016/j.lwt.2014.03.016
    [65] Parapouli M, Sfakianaki A, Monokrousos N, et al. (2019) Comparative transcriptional analysis of flavour-biosynthetic genes of a native Saccharomyces cerevisiae strain fermenting in its natural must environment, vs. a commercial strain and correlation of the genes' activities with the produced flavour compounds. J Biol Res (Thessalon) 26: 5. doi: 10.1186/s40709-019-0096-8
    [66] Romano P, Capece A (2017) Wine microbiology. Starter Cultures in Food Production 255-282. doi: 10.1002/9781118933794.ch13
    [67] Bokulich NA, Thorngate JH, Richardson PM, et al. (2014) Microbial biogeography of wine grapes is conditioned by cultivar, vintage, and climate. Proc Natl Acad Sci USA 111: E139-148. doi: 10.1073/pnas.1317377110
    [68] Ciani M, Morales P, Comitini F, et al. (2016) Non-conventional yeast species for lowering ethanol content of wines. Front Microbiol 7: 642.
    [69] Maturano YP, Assof M, Fabani MP, et al. (2015) Enzymatic activities produced by mixed Saccharomyces and non-Saccharomyces cultures: relationship with wine volatile composition. Antonie Van Leeuwenhoek 108: 1239-1256. doi: 10.1007/s10482-015-0578-0
    [70] Tristezza M, Tufariello M, Capozzi V, et al. (2016) The oenological potential of hanseniaspora uvarum in simultaneous and sequential co-fermentation with Saccharomyces cerevisiae for industrial wine production. Front Microbiol 7: 670. doi: 10.3389/fmicb.2016.00670
    [71] Viana F, Belloch C, Valles S, et al. (2011) Monitoring a mixed starter of Hanseniaspora vineae-Saccharomyces cerevisiae in natural must: impact on 2-phenylethyl acetate production. Int J Food Microbiol 151: 235-240. doi: 10.1016/j.ijfoodmicro.2011.09.005
    [72] Medina K, Boido E, Farina L, et al. (2013) Increased flavour diversity of Chardonnay wines by spontaneous fermentation and co-fermentation with Hanseniaspora vineaeFood Chem 141: 2513-2521. doi: 10.1016/j.foodchem.2013.04.056
    [73] Kim DH, Hong YA, Park HD (2008) Co-fermentation of grape must by Issatchenkia orientalis and Saccharomyces cerevisiae reduces the malic acid content in wine. Biotechnol Lett 30: 1633-1638. doi: 10.1007/s10529-008-9726-1
    [74] Gobbi M, Comitini F, Domizio P, et al. (2013) Lachancea thermotolerans and Saccharomyces cerevisiae in simultaneous and sequential co-fermentation: a strategy to enhance acidity and improve the overall quality of wine. Food Microbiol 33: 271-281. doi: 10.1016/j.fm.2012.10.004
    [75] Comitini F, Gobbi M, Domizio P, et al. (2011) Selected non-Saccharomyces wine yeasts in controlled multistarter fermentations with Saccharomyces cerevisiaeFood Microbiol 28: 873-882. doi: 10.1016/j.fm.2010.12.001
    [76] Sadineni V, Kondapalli N, Obulam VSR (2011) Effect of co-fermentation with Saccharomyces cerevisiae and Torulaspora delbrueckii or Metschnikowia pulcherrima on the aroma and sensory properties of mango wine. Ann Microbiol 62: 1353-1360. doi: 10.1007/s13213-011-0383-6
    [77] Parapouli M, Hatziloukas E, Drainas C, et al. (2010) The effect of Debina grapevine indigenous yeast strains of Metschnikowia and Saccharomyces on wine flavour. J Ind Microbiol Biotechnol 37: 85-93. doi: 10.1007/s10295-009-0651-7
    [78] Saez JS, Lopes CA, Kirs VC, et al. (2010) Enhanced volatile phenols in wine fermented with Saccharomyces cerevisiae and spoiled with Pichia guilliermondii and Dekkera bruxellensisLett Appl Microbiol 51: 170-176.
    [79] Azzolini M, Fedrizzi B, Tosi E, et al. (2012) Effects of Torulaspora delbrueckii and Saccharomyces cerevisiae mixed cultures on fermentation and aroma of Amarone wine. European Food Res Technol 235: 303-313. doi: 10.1007/s00217-012-1762-3
    [80] Renault P, Coulon J, de Revel G, et al. (2015) Increase of fruity aroma during mixed T. delbrueckii/S. cerevisiae wine fermentation is linked to specific esters enhancement. Int J Food Microbiol 207: 40-48. doi: 10.1016/j.ijfoodmicro.2015.04.037
    [81] Izquierdo Cañas PM, García-Romero E, Heras Manso JM, et al. (2014) Influence of sequential inoculation of Wickerhamomyces anomalus and Saccharomyces cerevisiae in the quality of red wines. European Food Res Technol 239: 279-286. doi: 10.1007/s00217-014-2220-1
    [82] Kontoudakis N, Gonzalez E, Gil M, et al. (2011) Influence of wine pH on changes in color and polyphenol composition induced by micro-oxygenation. J Agric Food Chem 59: 1974-1984. doi: 10.1021/jf103038g
    [83] Ozturk B, Anli E (2014) Different techniques for reducing alcohol levels in wine: A review. BIO Web of Conferences 3: 02012. doi: 10.1051/bioconf/20140302012
    [84] García-Martín N, Perez-Magariño S, Ortega-Heras M, et al. (2010) Sugar reduction in musts with nanofiltration membranes to obtain low alcohol-content wines. Sep Purif Technol 76: 158-170. doi: 10.1016/j.seppur.2010.10.002
    [85] Salgado CM, Palacio L, Prádanos P, et al. (2015) Comparative study of red grape must nanofiltration: Laboratory and pilot plant scales. Food Bioprod Process 94: 610-620. doi: 10.1016/j.fbp.2014.08.007
    [86] Mira H, de Pinho MN, Guiomar A, et al. (2017) Membrane processing of grape must for control of the alcohol content in fermented beverages. J Membr Sci Res 3: 308-312.
    [87] Barrio E, González SS, Arias A, et al. (2006) Molecular mechanisms involved in the adaptive evolution of industrial yeasts. Yeasts in food and beverages Berlin, Heidelberg: Springer Berlin Heidelberg, 153-174. doi: 10.1007/978-3-540-28398-0_6
    [88] Alonso-Del-Real J, Contreras-Ruiz A, Castiglioni GL, et al. (2017) The use of mixed populations of Saccharomyces cerevisiae and S. kudriavzevii to reduce ethanol content in wine: limited aeration, inoculum proportions, and sequential inoculation. Front Microbiol 8: 2087. doi: 10.3389/fmicb.2017.02087
    [89] Wang C, Mas A, Esteve-Zarzoso B (2016) The interaction between Saccharomyces cerevisiae and non-Saccharomyces yeast during alcoholic fermentation is species and strain specific. Front Microbiol 7: 502.
    [90] Curiel JA, Morales P, Gonzalez R, et al. (2017) Different non-Saccharomyces yeast species stimulate nutrient consumption in S. cerevisiae mixed cultures. Front Microbiol 8: 2121. doi: 10.3389/fmicb.2017.02121
    [91] Branco P, Francisco D, Chambon C, et al. (2014) Identification of novel GAPDH-derived antimicrobial peptides secreted by Saccharomyces cerevisiae and involved in wine microbial interactions. Appl Microbiol Biotechnol 98: 843-853. doi: 10.1007/s00253-013-5411-y
    [92] Perez-Torrado R, Rantsiou K, Perrone B, et al. (2017) Ecological interactions among Saccharomyces cerevisiae strains: insight into the dominance phenomenon. Sci Rep 7: 43603. doi: 10.1038/srep43603
    [93] Longo R, Blackman JW, Torley PJ, et al. (2017) Changes in volatile composition and sensory attributes of wines during alcohol content reduction. J Sci Food Agric 97: 8-16. doi: 10.1002/jsfa.7757
    [94] Heitmann M, Zannini E, Arendt E (2018) Impact of Saccharomyces cerevisiae metabolites produced during fermentation on bread quality parameters: A review. Crit Rev Food Sci Nutr 58: 1152-1164. doi: 10.1080/10408398.2016.1244153
    [95] Joseph R, Bachhawat AK (2014) Yeasts: Production and Commercial Uses. Encyclopedia of Food Microbiology, 2 Eds Oxford: Academic Press, 823-830. doi: 10.1016/B978-0-12-384730-0.00361-X
    [96] Nielsen J (2019) Yeast systems biology: model organism and cell factory. Biotechnol J 14: e1800421. doi: 10.1002/biot.201800421
    [97] Money NP (2018)  The Rise of Yeast: How the Sugar Fungus Shaped Civilization Oxford University Press.
    [98] Carbonetto B, Ramsayer J, Nidelet T, et al. (2018) Bakery yeasts, a new model for studies in ecology and evolution. Yeast 35: 591-603. doi: 10.1002/yea.3350
    [99] Duan SF, Han PJ, Wang QM, et al. (2018) The origin and adaptive evolution of domesticated populations of yeast from Far East Asia. Nat Commun 9: 2690. doi: 10.1038/s41467-018-05106-7
    [100] Menezes R, Tenreiro S, Macedo D, et al. (2015) From the baker to the bedside: yeast models of Parkinson's disease. Microb Cell 2: 262-279. doi: 10.15698/mic2015.08.219
    [101] Hidalgo A, Brandolini A (2014) BREAD | Bread from Wheat Flour. Encyclopedia of Food Microbiology, 2Eds Oxford: Academic Press, 303-308. doi: 10.1016/B978-0-12-384730-0.00044-6
    [102] De Vuyst L, Harth H, Van Kerrebroeck S, et al. (2016) Yeast diversity of sourdoughs and associated metabolic properties and functionalities. Int J Food Microbiol 239: 26-34. doi: 10.1016/j.ijfoodmicro.2016.07.018
    [103] Legras JL, Merdinoglu D, Cornuet JM, et al. (2007) Bread, beer and wine: Saccharomyces cerevisiae diversity reflects human history. Mol Ecol 16: 2091-2102. doi: 10.1111/j.1365-294X.2007.03266.x
    [104] Albertin W, Marullo P, Aigle M, et al. (2009) Evidence for autotetraploidy associated with reproductive isolation in Saccharomyces cerevisiae: towards a new domesticated species. J Evol Biol 22: 2157-2170. doi: 10.1111/j.1420-9101.2009.01828.x
    [105] Peter J, De Chiara M, Friedrich A, et al. (2018) Genome evolution across 1,011 Saccharomyces cerevisiae isolates. Nature 556: 339-344. doi: 10.1038/s41586-018-0030-5
    [106] De Bellis P, Rizzello CG, Sisto A, et al. (2019) Use of a selected Leuconostoc Citreum strain as a starter for making a ‘Yeast-Free’ bread. Foods 8: 70. doi: 10.3390/foods8020070
    [107] Heitmann M, Zannini E, Arendt EK (2015) Impact of different beer yeasts on wheat dough and bread quality parameters. J Cereal Sci $V 63: 49-56. doi: 10.1016/j.jcs.2015.02.008
    [108] Schwan RF, Wheals AE (2004) The microbiology of cocoa fermentation and its role in chocolate quality. Crit Rev Food Sci Nutr 44: 205-221. doi: 10.1080/10408690490464104
    [109] De Vuyst L, Weckx S (2016) The cocoa bean fermentation process: from ecosystem analysis to starter culture development. J Appl Microbiol 121: 5-17. doi: 10.1111/jam.13045
    [110] Aprotosoaie AC, Luca SV, Miron A (2016) Flavor chemistry of Cocoa and Cocoa products-an overview. Compr Rev Food Sci Food Saf 15: 73-91. doi: 10.1111/1541-4337.12180
    [111] Gutiérrez TJ (2017) State-of-the-Art Chocolate manufacture: a review. Compr Rev Food Sci Food Saf 16: 1313-1344. doi: 10.1111/1541-4337.12301
    [112] Papalexandratou Z, De Vuyst L (2011) Assessment of the yeast species composition of cocoa bean fermentations in different cocoa-producing regions using denaturing gradient gel electrophoresis. FEMS Yeast Res 11: 564-574. doi: 10.1111/j.1567-1364.2011.00747.x
    [113] Meersman E, Steensels J, Struyf N, et al. (2016) Tuning chocolate flavor through development of thermotolerant Saccharomyces cerevisiae starter cultures with increased acetate ester production. Appl Environ Microbiol 82: 732-746. doi: 10.1128/AEM.02556-15
    [114] Meersman E, Steensels J, Paulus T, et al. (2015) Breeding strategy to generate robust yeast starter cultures for Cocoa pulp fermentations. Appl Environ Microbiol 81: 6166-6176. doi: 10.1128/AEM.00133-15
    [115] Ho VT, Zhao J, Fleet G (2014) Yeasts are essential for cocoa bean fermentation. Int J Food Microbiol 174: 72-87. doi: 10.1016/j.ijfoodmicro.2013.12.014
    [116] Ho VT, Zhao J, Fleet G (2015) The effect of lactic acid bacteria on cocoa bean fermentation. Int J Food Microbiol 205: 54-67. doi: 10.1016/j.ijfoodmicro.2015.03.031
    [117] Ho VTT, Fleet GH, Zhao J (2018) Unravelling the contribution of lactic acid bacteria and acetic acid bacteria to cocoa fermentation using inoculated organisms. Int J Food Microbiol 279: 43-56. doi: 10.1016/j.ijfoodmicro.2018.04.040
    [118] Schwan RF (1998) Cocoa fermentations conducted with a defined microbial cocktail inoculum. Appl Environ Microbiol 64: 1477-1483. doi: 10.1128/AEM.64.4.1477-1483.1998
    [119] Jespersen L, Nielsen DS, Honholt S, et al. (2005) Occurrence and diversity of yeasts involved in fermentation of West African cocoa beans. FEMS Yeast Res 5: 441-453. doi: 10.1016/j.femsyr.2004.11.002
    [120] Daniel HM, Vrancken G, Takrama JF, et al. (2009) Yeast diversity of Ghanaian cocoa bean heap fermentations. FEMS Yeast Res 9: 774-783. doi: 10.1111/j.1567-1364.2009.00520.x
    [121] Meersman E, Steensels J, Mathawan M, et al. (2013) Detailed analysis of the microbial population in Malaysian spontaneous cocoa pulp fermentations reveals a core and variable microbiota. PLoS One 8: e81559. doi: 10.1371/journal.pone.0081559
    [122] Ramos CL, Dias DR, Miguel M, et al. (2014) Impact of different cocoa hybrids (Theobroma cacao L.) and S. cerevisiae UFLA CA11 inoculation on microbial communities and volatile compounds of cocoa fermentation. Food Res Int 64: 908-918. doi: 10.1016/j.foodres.2014.08.033
    [123] Batista NN, Ramos CL, Ribeiro DD, et al. (2015) Dynamic behavior of Saccharomyces cerevisiae, Pichia kluyveri and Hanseniaspora uvarum during spontaneous and inoculated cocoa fermentations and their effect on sensory characteristics of chocolate. LWT-Food Sci Technol 63: 221-227. doi: 10.1016/j.lwt.2015.03.051
    [124] Mota-Gutierrez J, Botta C, Ferrocino I, et al. (2018) Dynamics and biodiversity of bacterial and yeast communities during fermentation of Cocoa beans. Appl Environ Microbiol 84: e01164-01118. doi: 10.1128/AEM.01164-18
    [125] Ardhana MM, Fleet GH (2003) The microbial ecology of cocoa bean fermentations in Indonesia. Int J Food Microbiol 86: 87-99. doi: 10.1016/S0168-1605(03)00081-3
    [126] Moreira IMdV, Miguel MGdCP, Duarte WF, et al. (2013) Microbial succession and the dynamics of metabolites and sugars during the fermentation of three different cocoa (Theobroma cacao L.) hybrids. Food Res Int 54: 9-17. doi: 10.1016/j.foodres.2013.06.001
    [127] Mota-Gutierrez J, Barbosa-Pereira L, Ferrocino I, et al. (2019) Traceability of functional volatile compounds generated on inoculated Cocoa fermentation and its potential health benefits. Nutrients 11: 884. doi: 10.3390/nu11040884
    [128] Castro-Alayo EM, Idrogo-Vasquez G, Siche R, et al. (2019) Formation of aromatic compounds precursors during fermentation of Criollo and Forastero cocoa. Heliyon 5: e01157. doi: 10.1016/j.heliyon.2019.e01157
    [129] Buamah R, Dzogbefia V, Oldham J (1997) Pure yeast culture fermentation of cocoa (Theobroma cacao L): effect on yield of sweatings and cocoa bean quality. World J Microbiol Biotechnol 13: 457-462. doi: 10.1023/A:1018536519325
    [130] Meersman E, Struyf N, Kyomugasho C, et al. (2017) Characterization and degradation of pectic polysaccharides in cocoa pulp. J Agric Food Chem 65: 9726-9734. doi: 10.1021/acs.jafc.7b03854
    [131] Lefeber T, Papalexandratou Z, Gobert W, et al. (2012) On-farm implementation of a starter culture for improved cocoa bean fermentation and its influence on the flavour of chocolates produced thereof. Food Microbiol 30: 379-392. doi: 10.1016/j.fm.2011.12.021
    [132] Visintin S, Ramos L, Batista N, et al. (2017) Impact of Saccharomyces cerevisiae and Torulaspora delbrueckii starter cultures on cocoa beans fermentation. Int J Food Microbiol 257: 31-40. doi: 10.1016/j.ijfoodmicro.2017.06.004
    [133] Magalhaes da Veiga Moreira I, de Figueiredo Vilela L, da Cruz Pedroso Miguel MG, et al. (2017) Impact of a microbial cocktail used as a starter culture on cocoa fermentation and chocolate flavor. Molecules 22. doi: 10.3390/molecules22050766
    [134] Menezes AGT, Batista NN, Ramos CL, et al. (2016) Investigation of chocolate produced from four different Brazilian varieties of cocoa ( Theobroma cacao L.) inoculated with Saccharomyces cerevisiaeFood Res Int 81: 83-90. doi: 10.1016/j.foodres.2015.12.036
    [135] Assi-Clair BJ, Koné MK, Kouamé K, et al. (2019) Effect of aroma potential of Saccharomyces cerevisiae fermentation on the volatile profile of raw cocoa and sensory attributes of chocolate produced thereof. European Food Res Technol 245: 1459-1471. doi: 10.1007/s00217-018-3181-6
    [136] Songstad D, Lakshmanan P, Chen J, et al. (2009) Historical perspective of biofuels: learning from the past to rediscover the future. In Vitro Cell Dev Biol: Plant 45: 189-192. doi: 10.1007/s11627-009-9218-6
    [137] Guo M, Song W, Buhain J (2015) Bioenergy and biofuels: history, status, and perspective. Renewable Sustainable Energy Rev 42: 712-725. doi: 10.1016/j.rser.2014.10.013
    [138] Balat M, Balat H (2009) Recent trends in global production and utilization of bio-ethanol fuel. Applied energy 86: 2273-2282. doi: 10.1016/j.apenergy.2009.03.015
    [139] John RP, Anisha GS, Nampoothiri KM, et al. (2011) Micro and macroalgal biomass: a renewable source for bioethanol. Bioresour Technol 102: 186-193. doi: 10.1016/j.biortech.2010.06.139
    [140] Nigam PS, Singh A (2011) Production of liquid biofuels from renewable resources. Progress in energy and combustion science 37: 52-68. doi: 10.1016/j.pecs.2010.01.003
    [141] Mohd Azhar SH, Abdulla R, Jambo SA, et al. (2017) Yeasts in sustainable bioethanol production: A review. Biochem Biophys Rep 10: 52-61.
    [142] Pilgrim C, Vierhout R (2017) Status of the worldwide fuel alcohol industry. The alcohol textbook 1-22.
    [143] Walker GM, Walker RS (2018) Enhancing yeast alcoholic fermentations. Adv Appl Microbiol 68: 87-129. doi: 10.1016/bs.aambs.2018.05.003
    [144] Walker GM (2004) Metals in yeast fermentation processes. Adv Appl Microbiol 54: 197-229. doi: 10.1016/S0065-2164(04)54008-X
    [145] Flores JA, Gschaedler A, Amaya-Delgado L, et al. (2013) Simultaneous saccharification and fermentation of Agave tequilana fructans by Kluyveromyces marxianus yeasts for bioethanol and tequila production. Bioresour Technol 146: 267-273. doi: 10.1016/j.biortech.2013.07.078
    [146] Passoth V, Blomqvist J, Schnurer J (2007) Dekkera bruxellensis and Lactobacillus vini form a stable ethanol-producing consortium in a commercial alcohol production process. Appl Environ Microbiol 73: 4354-4356. doi: 10.1128/AEM.00437-07
    [147] Liang M, Damiani A, He QP, et al. (2013) Elucidating xylose metabolism of Scheffersomyces stipitis for lignocellulosic ethanol production. ACS Sustainable Chem Eng 2: 38-48. doi: 10.1021/sc400265g
    [148] Obata O, Akunna J, Bockhorn H, et al. (2016) Ethanol production from brown seaweed using non-conventional yeasts. Bioethanology 2: 134-145.
    [149] Nandy SK, Srivastava RK (2018) A review on sustainable yeast biotechnological processes and applications. Microbiol Res 207: 83-90. doi: 10.1016/j.micres.2017.11.013
    [150] Giudici P, Zambonelli C, Kunkee R (1993) Increased production of n-propanol in wine by yeast strains having an impaired ability to form hydrogen sulfide. Am J Enol Vitic 44: 17-21.
    [151] Nishimura Y (2016) 1-Propanol production of S. cerevisiae engineering 2-Ketobutyrate biosynthetic pathway.
    [152] Buijs NA, Siewers V, Nielsen J (2013) Advanced biofuel production by the yeast Saccharomyces cerevisiaeCurr Opin Chem Biol 17: 480-488. doi: 10.1016/j.cbpa.2013.03.036
    [153] Schadeweg V, Boles E (2016) n-Butanol production in Saccharomyces cerevisiae is limited by the availability of coenzyme A and cytosolic acetyl-CoA. Biotechnol biofuels 9: 44. doi: 10.1186/s13068-016-0456-7
    [154] Anthony LC, Huang LL, Rick WY (2014) Production of isobutanol in yeast mitochondria. Google Patents.
    [155] Festel G, Boles E, Weber C, et al. (2013) Fermentative production of isobutanol with yeast. Google Patents.
    [156] Urano J, Dundon CA (2012) Cytosolic isobutanol pathway localization for the production of isobutanol. Google Patents.
    [157] Walker GM (2014) Fermentation (Industrial): media for industrial fermentations. Encyclopedia of food microbiology, 2Eds Academic Press, 769-777. doi: 10.1016/B978-0-12-384730-0.00107-5
    [158] Alvira P, Tomas-Pejo E, Ballesteros M, et al. (2010) Pretreatment technologies for an efficient bioethanol production process based on enzymatic hydrolysis: A review. Bioresour Technol 101: 4851-4861. doi: 10.1016/j.biortech.2009.11.093
    [159] Yang B, Dai Z, Ding SY, et al. (2011) Enzymatic hydrolysis of cellulosic biomass. Biofuels 2: 421-449. doi: 10.4155/bfs.11.116
    [160] Canilha L, Chandel AK, Suzane dos Santos Milessi T, et al. (2012) Bioconversion of sugarcane biomass into ethanol: an overview about composition, pretreatment methods, detoxification of hydrolysates, enzymatic saccharification, and ethanol fermentation. BioMed Res Int 2012.
    [161] Chandel AK, Chan E, Rudravaram R, et al. (2007) Economics and environmental impact of bioethanol production technologies: an appraisal. Biotechnol Mol Biol Rev 2: 14-32.
    [162] Hadiyanto H, Ariyanti D, Aini A, et al. (2013) Batch and fed-batch fermentation system on ethanol production from whey using Kluyveromyces marxianusInt J Renewable Energy Dev 2: 127-131. doi: 10.14710/ijred.2.3.127-131
    [163] Cheng NG, Hasan M, Kumoro AC, et al. (2009) Production of ethanol by fed-batch fermentation. Pertanika J Sci Technol 17: 399-408.
    [164] Ivanova V, Petrova P, Hristov J (2011) Application in the ethanol fermentation of immobilized yeast cells in matrix of alginate/magnetic nanoparticles, on chitosan-magnetite microparticles and cellulose-coated magnetic nanoparticles. arXiv preprint arXiv 11050619.
    [165] Jain A, Chaurasia SP (2014) Bioethanol production in membrane bioreactor (MBR) system: a review. Int J Environ Res Dev 4: 387-394.
    [166] Kang Q, Appels L, Tan T, et al. (2014) Bioethanol from lignocellulosic biomass: current findings determine research priorities. Sci World J 2014: 298153.
    [167] Caspeta L, Chen Y, Ghiaci P, et al. (2014) Biofuels. Altered sterol composition renders yeast thermotolerant. Science 346: 75-78. doi: 10.1126/science.1258137
    [168] Phisalaphong M, Srirattana N, Tanthapanichakoon W (2006) Mathematical modeling to investigate temperature effect on kinetic parameters of ethanol fermentation. Biochem Eng J 28: 36-43. doi: 10.1016/j.bej.2005.08.039
    [169] Lam FH, Ghaderi A, Fink GR, et al. (2014) Biofuels. Engineering alcohol tolerance in yeast. Science 346: 71-75. doi: 10.1126/science.1257859
    [170] Trofimova Y, Walker G, Rapoport A (2010) Anhydrobiosis in yeast: influence of calcium and magnesium ions on yeast resistance to dehydration–rehydration. FEMS Microbiol Lett 308: 55-61. doi: 10.1111/j.1574-6968.2010.01989.x
    [171] Medina VG, Almering MJ, van Maris AJ, et al. (2010) Elimination of glycerol production in anaerobic cultures of a Saccharomyces cerevisiae strain engineered to use acetic acid as an electron acceptor. Appl Environ Microbiol 76: 190-195. doi: 10.1128/AEM.01772-09
    [172] Lopes ML, de Lima Paulillo SC, Godoy A, et al. (2016) Ethanol production in Brazil: a bridge between science and industry. Braz J Microbiol 47: 64-76. doi: 10.1016/j.bjm.2016.10.003
    [173] Carvalho-Netto OV, Carazzolle MF, Mofatto LS, et al. (2015) Saccharomyces cerevisiae transcriptional reprograming due to bacterial contamination during industrial scale bioethanol production. Microb Cell Fact 14: 13. doi: 10.1186/s12934-015-0196-6
    [174] Steensels J, Snoek T, Meersman E, et al. (2014) Improving industrial yeast strains: exploiting natural and artificial diversity. FEMS Microbiol Rev 38: 947-995. doi: 10.1111/1574-6976.12073
    [175] Basso LC, de Amorim HV, de Oliveira AJ, et al. (2008) Yeast selection for fuel ethanol production in Brazil. FEMS Yeast Res 8: 1155-1163. doi: 10.1111/j.1567-1364.2008.00428.x
    [176] Kim JH, Ryu J, Huh IY, et al. (2014) Ethanol production from galactose by a newly isolated Saccharomyces cerevisiae KL17. Bioprocess Biosyst Eng 37: 1871-1878. doi: 10.1007/s00449-014-1161-1
    [177] Deparis Q, Claes A, Foulquie-Moreno MR, et al. (2017) Engineering tolerance to industrially relevant stress factors in yeast cell factories. FEMS Yeast Res 17. doi: 10.1093/femsyr/fox036
    [178] Demeke MM, Foulquie-Moreno MR, Dumortier F, et al. (2015) Rapid evolution of recombinant Saccharomyces cerevisiae for xylose fermentation through formation of extra-chromosomal circular DNA. PLoS Genet 11: e1005010. doi: 10.1371/journal.pgen.1005010
    [179] Wright SA (2017) Worldwide distilled spirits production. The alcohol textbook, 6 Eds 23-39.
    [180] Kumari R, Pramanik K (2013) Bioethanol production from Ipomoea carnea biomass using a potential hybrid yeast strain. Appl Biochem Biotechnol 171: 771-785. doi: 10.1007/s12010-013-0398-5
    [181] Ariyajaroenwong P, Laopaiboon P, Jaisil P, et al. (2012) Repeated-batch ethanol production from sweet sorghum juice by Saccharomyces cerevisiae immobilized on sweet sorghum stalks. Energies 5: 1215-1228. doi: 10.3390/en5041215
    [182] Argyros DA, Stonehouse EA (2017) Yeast train improvement for alcohol production. The alcohol textbook 287-297.
    [183] Ingledew WM (2017) Very high gravity (VHG) and associated new technologies for fuel alcohol production. The alcohol textbook 363-376.
    [184] Matsushika A, Inoue H, Kodaki T, et al. (2009) Ethanol production from xylose in engineered Saccharomyces cerevisiae strains: current state and perspectives. Appl Microbiol Biotechnol 84: 37-53. doi: 10.1007/s00253-009-2101-x
  • Reader Comments
  • © 2020 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Metrics

Article views(18805) PDF downloads(2098) Cited by(151)

Article outline

Figures and Tables

Tables(1)

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return

Catalog