Department of Gastroenterology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, 310004, Zhejiang Province, China
2.
Departments of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, 310004, Zhejiang Province, China
Received:
14 March 2019
Accepted:
17 December 2019
Published:
24 April 2020
To investigate the significance of lymph node micrometastasis in T1N0 early gastric cancer. Lymph node micrometastasis may be a key mechanism in the recurrent T1N0 EGC patients after surgical treatment. It's unknow whether it is safe to leave the lymph nodes with micrometastasis untreated after ESD. A total of 106 T1N0 EGC patients were enrolled in this study. Immunohistochemical technique with CAM5.2 was employed to detect lymph node micrometastasis, and Immunohistochemical with D2-40 was used to detect the lymphatic vessels. Prognostic significance of lymph node micrometastasis and the relationship of lymph nodes micrometastasis with Clinicopathological features were analyzed. Twenty-two of the 106 T1N0 EGC cases were detected with lymph nodes micrometastasis, with the detection rate of 20.8%. The median survival time of the group with positive lymph nodes micrometastasis was lower than that of the group with negative micrometastasis, 48 vs 60 months. The incidence of lymph nodes micrometastasis in submucosal T1N0 EGC was 23.9%, while no micrometastasis was found in the mucosal T1N0 EGC. Of all the 30 cases according with the expanded ESD indications, six patients were found with lymph nodes micrometastasis. The occurrence of lymph node micrometastasis was common in T1N0 EGC. The cases with positive lymph nodes micrometastasis showed a lower median survival time than those with negative micrometastasis. lymph nodes micrometastasis incidence was higher in the submucosal ECG than in the mucosal ECG. lymph nodes micrometastasis was also found in the cases according to the expanded ESD indications.
Citation: Guochun Lou, Jie Dong, Jing Du, Wanyuan Chen, Xianglei He. Clinical significance of lymph node micrometastasis in T1N0 early gastric cancer[J]. Mathematical Biosciences and Engineering, 2020, 17(4): 3252-3259. doi: 10.3934/mbe.2020185
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Abstract
To investigate the significance of lymph node micrometastasis in T1N0 early gastric cancer. Lymph node micrometastasis may be a key mechanism in the recurrent T1N0 EGC patients after surgical treatment. It's unknow whether it is safe to leave the lymph nodes with micrometastasis untreated after ESD. A total of 106 T1N0 EGC patients were enrolled in this study. Immunohistochemical technique with CAM5.2 was employed to detect lymph node micrometastasis, and Immunohistochemical with D2-40 was used to detect the lymphatic vessels. Prognostic significance of lymph node micrometastasis and the relationship of lymph nodes micrometastasis with Clinicopathological features were analyzed. Twenty-two of the 106 T1N0 EGC cases were detected with lymph nodes micrometastasis, with the detection rate of 20.8%. The median survival time of the group with positive lymph nodes micrometastasis was lower than that of the group with negative micrometastasis, 48 vs 60 months. The incidence of lymph nodes micrometastasis in submucosal T1N0 EGC was 23.9%, while no micrometastasis was found in the mucosal T1N0 EGC. Of all the 30 cases according with the expanded ESD indications, six patients were found with lymph nodes micrometastasis. The occurrence of lymph node micrometastasis was common in T1N0 EGC. The cases with positive lymph nodes micrometastasis showed a lower median survival time than those with negative micrometastasis. lymph nodes micrometastasis incidence was higher in the submucosal ECG than in the mucosal ECG. lymph nodes micrometastasis was also found in the cases according to the expanded ESD indications.
1.
Introduction
Supply chain management (SCM) operates in certain functional sectors to grow businesses and increase consumer value. These functions include controlling inventories, managing material and product quality, packaging, warehousing, logistics, and recycling. In the past, the manufacturers have been the ones who have designed the supply chain. Retailers transfer all relevant data and money flows to upward SCM. However, retailers are sometimes unreliable in terms of their behavior. They hide consumer information from manufacturers. Thus, data asymmetry issues often arise, rendering the entire system unreliable. Hence, data safety is a major factor in eliminating unreliability.
Although retailers are major players in SCM because they have the opportunity to deal directly with consumers, they are sometimes the main reason for system unreliability. However, retailers may also provide additional services to customers to increase their profits. Furthermore, retailers may keep this information confidential from the manufacturers. Consequently, asymmetric information flows throughout the system. Therefore, the manufacturer is willing to implement a vendor-managed inventory (VMI) policy. The manufacturer maintains the inventory level for each retailer. The VMI policy discusses the sharing of retailers carrying costs.
The manufacturer sends finished products to all the retailers at distinct locations using forward logistics. The manufacturer accumulates all items utilized by each retailer through reverse logistics. The cost of reverse logistics varies with the rate of accumulated used goods. Realistically, it is impossible to gather all sold products, implying a 100% accumulation rate. Both forward and backward logistics emit carbon into the atmosphere. Industries are taking the initiative to reduce carbon emissions to protect the environment. Industries are charged a certain amount for every ton of carbon emissions they produce, a carbon tax. The cap-and-trade (CAPT) policy sets a permitted higher emissions limit, and a cap on production factories. Moreover, if an unconsumed emissions limit exists after production, the industry sells that extra emissions limit to another industry (trade). This supports the tracking of total emissions.
A distinct literature related to the VMI supply chain highlights factors such as information asymmetry, carbon emissions reduction, and forward and backward logistics. Currently, demand is a major aspect of marketing. Most studies have dealt with fuzziness, lead time, advertisement, a distribution-free approach, and all the factors discussed earlier. However, random lead time demand with unreliability, carbon tax, CAPT policy, and forward and reverse logistics in a two-echelon VMI supply chain have not yet been discussed. This is the largest research gap concerning random lead time demand in an unreliable supply chain, together with the carbon tax, CAPT policy, VMI contracts, forward and reverse logistics, reorder points, and safety stock. From this point of view, this research gap has motivated us to conduct this research.
1.1. Contribution of the study
The proposed contribution fills the research gap in the literature by recommending random lead time demand with two types of distribution functions that incorporate a carbon tax, CAPT policy from an environmental perspective, consideration of safety stock, reorder points, and VMI system into an unreliable supply chain model.
The other goals of this research are as follows. First, to discard information asymmetry from SCM. Second, to incorporate a VMI contract for SCM coordination. Third, to control random demand to fulfill supply chain demand. Fourth, to adapt a CAPT policy in consideration of the environment. Finally, to improve economic growth and SCM collaboration for an everlasting business association. The significant contributions of this study are as follows:
(a) This study is conducted to discard unreliability factors from the supply chain system.
(b) VMI policy is highlighted to eliminate this unreliable matter from the supply chain.
(c) Random lead time demand under two distribution functions, uniform and normal, is considered to handle uncertainty.
(d) Environmental characteristics are observed through a carbon tax, CAPT policy, and accumulated utilized items.
(e) An improved economic benefit is provided for the industry compared to previous literature.
1.2. Structure of the study
The remainder of this paper is structured as follows. Section 3 elaborates on the problem definition, notation, and hypothesis. Section 4 represents mathematical modelling. Section 5 describes a numerical example with a comparative graphical presentation. Section 6 presents the sensitivity analyses with diagrammatic illustrations. In Section 7, important managerial insights from this study are discussed. Section 8 presents this study's conclusions, limitations, findings, and recommendations. Finally, some references utilized throughout the model are provided.
2.
Literature review
This section presents a detailed literature review. The discussion is based on the keywords used in this research.
2.1. Unreliable retailers and information asymmetry
As retailers are the last members of upward SCM, they receive major data regarding their customer requirements, information on their investments in customer satisfaction, and knowledge about upcoming market trends. However, in some cases, the retailers are unreliable. In such cases, information asymmetry occurs throughout the system. This asymmetry of retailer data creates unfaithful circumstances within SCM. This directly impacts inventory and can effect profits. Avinadav et al. [1] studied the idea of an ex-post voluntary declaration under information asymmetry, along with a revenue-contributing technique. They found that communicating with a risk-averse retailer is much more profitable for the manufacturer than communicating with a risk-neutral retailer under hidden superiority. Guchhait and Sarkar [2] formulated a mathematical model to reduce system unreliability. By contrast, the manufacturer used a VMI policy for several unreliable retailers. Fallahpour et al. [3] examined an integrated system to develop sustainability and Industry 4.0, the principles of supplier selection management. Their study assumed the fuzzy best-worst method (FBWM) and a two-stage fuzzy inference system (FIS) to determine supplier selection. Xu and Xu [4] presented a two-echelon supply chain model for production and distribution enterprises. They discussed a signal game model in which manufacturing enterprises select channel encroachment without information. They showed that while the direct selling cost was maximum, encroachment benefited the distribution enterprise.
2.2. Vendor-managed inventory (VMI)
With the help of this policy, the manufacturer can eliminate the system's unreliability, as it has the power to control supply chain management. Based on the agreement of the VMI policy, the manufacturer is responsible for taking care of the retailer's holding costs and shares the revenue of the total profit. This policy ensures inventory shrinkage and maintains symmetrical information in supply chain management. First, the VMI policy reduces the system's unreliability. However, this policy supports retailers in reducing their total costs and achieving profits. By adopting the concept of environmental pollution along with green emissions, Karampour et al. [5] presented a two-echelon supply chain model to offer a green backorder for VMI and carbon emission reduction. Their model justified optimality by inserting a non-dominated sorting genetic algorithm (NSGA-II), multi-objective Keshtel algorithm, and multi-objective deer algorithm. Taleizadeh et al. [6] applied a VMI policy to a system with a single vendor and two retailers. They differentiated between the (R,T) and (r,Q) replenishment methods to determine which method was more cost-effective under partial backlogging. Bertazzi et al. [7] addressed a long–haul transportation method in which full container load deliveries on one side and less than container load or air freight shipments were integrated under the VMI policy. Asadkhani et al. [8] considered a vendor-buyer supply chain model with vendor-managed inventory with a consignment stock (VMI-CS) contract. The vendor carried the buyer's financial holding costs according to the contract. In addition, each shipment included a random portion of repairable products that needed to be removed from the inventory system.
2.3. Cap and trade (CAPT) policy and carbon tax
The amount of carbon emitted into the air is higher during forward and backward logistics. The CAPT policy can control carbon emission levels. The manufacturer pays an amount for each ton of carbon emitted (carbon tax). It is uncertain how much carbon will be emitted by any industry. The CAPT policy sets the authorized maximum emission limit (i.e., the cap on industries). The industry must purchase additional limits if the maximum emission level is achieved during manufacturing. The industry with an extra unutilized limit sells that limit to other factories according to their requirements, that is, trade. Ma et al. [9] developed a mathematical model to determine the effect of a carbon tax. A supplier evaluation technique was used to select the suppliers to fulfill the manufacturer's random demand. Later, Fathollahi-Fard et al. [10] described a truck-scheduling model using a cross-docking system. Their model was used to formulate three new social engineering optimizers to solve the truck scheduling problem. They also determined the optimal circumstances for receiving and transferring truck sequences. Manupati et al. [11] investigated various inventory models in the multi-echelon supply chain with strict carbon capping, carbon tax, and CAPT policies under the consideration of lead time. Zhou et al. [12] analyzed the research advancements in SCM in the carbon tax field by observing a collaboration between qualitative and quantitative techniques. Sarkar and Guchhait [13] expanded the earlier literature with a hybrid closed-loop SCM in cooperation, in which the carbon cap restricted emissions from the vendor's entire hybrid manufacturing system. Certain elements were considered in their study, such as service provided by the retailer, product quality, gift process, and customer awareness by the vendor. Their model analyzed the situation under random market demand. Their study highlighted the techniques vendors and other supply chain players use to contribute to reproduction responsibility. Table 1 provides a comparable study to the earlier literature.
This section briefly discusses this study's limitations. This section presents all associated notation and hypotheses for the proposed model.
3.1. Problem definition
This study presents a two-echelon SCM model with a single manufacturer and multiple unreliable retailers for one product type. Each retailer within this SCM is independent of other retailers. As these retailers are unreliable, asymmetry occurs in the system data. The manufacturer utilizes the VMI technique to control inventories to overcome this unreliability. Under VMI policy, the manufacturer handles the inventory from each retailer. Although retailers order products, manufacturers decide how much time to replenish and schedule products. Furthermore, the manufacturer pays each retailer the inventory cost. The entire management system is under the CAPT policy, and a carbon tax is charged to the manufacturer for carbon emissions. This study considers both forward and backward logistics. All utilized products are acquired from each retailer and returned to the manufacturer during reverse logistics. The return rate of the products is β. The retailer's lead time demand for items follows uniform and normal distribution function.
3.2. Notation
The following notation is used to generate the proposed model:
Index
r
retailer r, r=1,2,...,n
Decision
variables
sr
service provided by the retailer r to customers
lr
retailer r's lot size (units/cycle)
qr
safety stock of the retailer r
Nr
number of times the manufacturer produces qr quantity (integer)
Dependent
variable
Qm
manufacturer's lot size (units/cycle), Qm=∑nr=1lr
Rr
reorder point of retailer r (units/cycle)
Parameters
Lr
retailer r's lead time (week)
dr
retailer r's demand (unit/unit time)
D
manufacturer's demand D=∑nrdr (unit/unit time)
P
constant production rate of the manufacturer (unit/unit time)
yr
retailer r's per unit selling price ($/unit)
Cm
cost of manufacturing per unit product ($/unit)
Cp
purchasing cost of retailer r from the manufacturer per unit product
(wholesale price of the manufacturer) ($/unit)
Csr
cost of stockout of retailer r per unit ($/unit)
C0sr
marginal profit due to partial backorder shortage of retailer r per unit ($/unit)
Chm
manufacturer's holding cost per unit per unit time ($/unit/unit time)
Chr
retailer r's carrying cost ($/unit/unit time)
Ar
cost for ordering of retailer r ($/order)
Ir
retailer r's service investment ($/cycle)
Xr
retailer r's random lead time demand having cumulative distribution function
(c.d.f.) F
MrLr
mean of lead time demand Xr
σr√Lr
standard deviation of lead time demand Xr
ar,br
minimum and maximum parametric value of the interval (Xr∼U(ar,br))
g1
emitted carbon from production (gallon/unit)
g2
emitted carbon from transportation (gallon/km)
f
carbon tax per unit item ($/unit)
Mc
carbon cap limit of the manufacturer (gallon/cycle)
Pc
cost of purchasing carbon cap ($/unit)
Tc
trading price of non-utilized carbon cap limit ($/unit)
Jmr
distance from manufacturer to rth retailer in forward logistics (km)
Jrm
distance from rth retailer to manufacturer in reverse logistics (km)
The following hypotheses are taken to originate the proposed research.
1) In this research, a two-echelon SCM is illustrated in which a single manufacturer and multiple retailers are there. The manufacturer produces a single type of product and transfers it to several retailers. Because there is only one manufacturer, the wholesale price per unit product, that is, Cp, remains fixed for all retailers. In addition, n retailers are positioned in various locations, and therefore selling price of per unit product, i.e., yr fluctuates [14,15,16].
2) In that two-echelon SCM model, retailers are assumed as unreliable. For example, retailers provide useful services to their customers, however, the manufacturer is unaware of this information. Retailers may hide some valuable data from the manufacturer. This results in information asymmetry throughout the system. The manufacturer applies VMI policy to control this situation and clear unreliability from the entire system. By the contract of this policy, the manufacturer shares the carrying cost of retailers [17,18].
3) In this model, the market demand for products is fixed. Retailer r's lead time demand for products follows some distribution functions Xr, which are uniform and normal distribution functions [19]. Retailer r has a backorder rate ϕr(0<ϕr<1) due to the random lead time demand.
4) The entire system emits carbon at the time of production and transportation from manufacturer to retailers. The manufacturer pays a carbon tax to the government for carbon emissions. The CAPT policy restricts the limit of emitted carbon for the manufacturer. The manufacturer cannot emit carbon higher than the carbon emissions limit (cap). If the production system emits lower carbon than the emissions limit, the manufacturer sells the new extra emissions limit to other industries (trade) [20].
5) While the retailer's inventory level touches the reorder point, the retailer orders products from the manufacturer. The reorder point (Rr) of retailer r is Rr=∑nr=1(MrLr+qrσr√Lr), where MrLr is the expected value and σr√Lr is the standard deviation of the random variable Xr. qrσr√Lr is the safety stock and qr is the safety factor of the retailer r. Here, the safety factor qr is considered a decision variable instead of reorder point Rr[21,22].
6) This research analyzes two types of logistics during the transfer of finished products from the manufacturer to each retailer. Through forward logistics, the manufacturer transport products to several retailers, and by reverse logistics, all the utilized products are accumulated from all retailers to the manufacturer. The cost during reverse logistics varies with the acquired used items [23].
4.
Mathematical modelling
A single manufacturer develops a single type of product, and after that, those products are sent to n number of retailers. r retailers are having their demand of products D=∑nr=1dr and are ordering products of Qm=∑nr=1lr. VMI is utilized to maintain the inventory by the manufacturer. The manufacturer accumulates the used items. The manufacturer analyzes the emitted carbon from the production system. The manufacturer pays for the carbon emissions, and after that, bound the emitted carbon in the atmosphere, the CAPT policy is taken. Retailer's lead time demand is observed as random and follows two distinct distribution functions, normal and uniform. Safety stock, lead time, and reorder point are adequately examined here. Further, the manufacturer & retailer's model and associated costs are clarified in the following section.
4.1. Manufacturer's model
All the related revenue (wholesale price and CAPT policy for emitted carbon) and costs of the manufacturer (manufacturing cost, transportation cost, holding cost, and carbon tax for emitted carbon) are discussed below. The manufacturer produces Nrlr quantity for every order lr and sends it to lr over Nr times. Subsequently, the cycle length of the manufacturer is ∑nr=1Nrlrdr=NQmD.
4.1.1. Manufacturing cost
The manufacturer produces products as per the ordering amount. The manufacturer produces NQm=∑nr=1Nrlr products for n retailers. If the unit cost of manufacturing is Cm, then the entire cost of manufacturing Qm items per cycle is (CmNQm)DNQm=CmD.
4.1.2. Wholesale price
The manufacturer sells the product to each retailer with a fixed wholesale price Cp. Once the manufacturer has received the total order of items Qm from all retailers, they gain revenue. This revenue per cycle is analyzed as (CpNQm)DNQm=CpD.
4.1.3. Carbon tax for emitted carbon
The manufacturer pays carbon tax for emissions from production and transportation. Each unit required energy in inventory processing performance. W=∑nr=1Jmr+∑nr=1Jrm is the entire transportation distance for forward and reverse logistics for delivering and collecting products. g1 is the per unit carbon emissions from the production section, and g2 is the per kilometer emitted carbon from the transportation sector. Subsequently, the total emitted carbon from two sectors, i.e., from the production and transportation sectors, is
Te=[g1NQm+g2W]DNQm.
In the aforementioned equation, the first term represents the carbon emissions from the manufacturing sector, and the second term stands for the emitted carbon from the transportation section. If f is per unit carbon tax paid by the manufacturer, then the entire carbon tax for emissions per cycle, that is, TCE is
TCE=fTe=f[g1D+g2WDNQm].
4.1.4. CAPT policy for emitted carbon
Using the CAPT policy, the manufacturer reduces unnecessary emitted carbon from the production sector. The manufacturer purchases several carbon cap (Mc) from any reputed agency or the government with some price Pc. Hence, the manufacturer can emit carbon (Te) up to the cap limit. Two scenarios may emerge during production time. In the first case, if a limit exists on some unused emissions, the manufacturer sells this limit to other industries at a given price Tc. In the second case, if the carbon emissions limit Mc is used up, the manufacturer will purchase another carbon limit from an external source. Subsequently, related expressions of the CAPT policy for emitted carbon are defined as
In the aforementioned equation, the first equation stands for the non-utilized capability of carbon emissions. The second equation is the shortage quantity of carbon emissions limit while the manufacturer emits maximum carbon rather than the cap limit. g1NQm is the emissions from the production section and g2W is the emissions from transportation. Hence, the revenue observed from the CAPT policy is Rc=Tc(Mc−Te)+−Pc(Te−Mc)+=Tc(Mc−Te)+(Tc−Pc)(Te−Mc)+. Applying the shortage amount of emitted carbon, the revenue is
The manufacturer considers several transportation costs when sending products to retailers and acquiring utilized products from retailers. Now, two types of transportation costs are taken in this model. First is a fixed cost, the constant base cost for the transport system, that is, Kf. That fixed transportation cost Kf is the lowest cost while transporting items, whatever the products and distance. Second is variable transportation cost Kv, which varies with the ordering items and distance between all retailers and the manufacturer. During forward logistics, the distance from the manufacturer to the retailer r is Jmr. Subsequently, the total transportation cost per cycle during forward logistics is
(Kf+Kv∑nr=1NrlrJmr)DNQm.
In addition, for reverse logistics, the distance from the manufacturer to the retailer r is Jrm. The accumulation rate of utilized products is β. The accumulated products for transportation is β∑nr=1NrlrJrm. The total transportation cost during reverse logistics is
(Kf+Kvβ∑nr=1NrlrJrm)DNQm.
Hence, the entire cost of transportation is
2KfDNQm+Kvn∑r=1dr(Jmr+βJrm).
4.1.6. Holding cost
The manufacturer receives Qm ordered products from r number of retailers and produces NQm quantity products at a rate P unit. The manufacturer delivers Qm products to all retailers over N times. Each retailer receives lr quantity over Nr times, that is, N=∑nr=1Nr. Dm=∑nr=1dr. Subsequently, the total inventory is
n∑r=1lr2[2drP+Nr(1−drP)−1].
Subsequently, the holding cost of the manufacturer is
Chmn∑r=1lr2[2drP+Nr(1−drP)−1].
In addition, the manufacturer pays the holding cost for retailers too, as per the VMI contract.
4.1.7. Total profit of the manufacturer
Equation (4.1) provides the expected total profit of the manufacturer per cycle, which is described as
It is considered that multiple retailers are with a single manufacturer in a two-echelon SCM. Retailers of the supply chain are untrustable. Retailers hide data from the manufacturer. In addition, retailers furnish some services to their customers; however, the manufacturer is unaware of this data. Consequently, information instability originates in the system. From the settlement of the VMI policy, the manufacturer bears the retailer's holding cost. The retailer r receives ordered quantity lr with a cycle time drlr.
In the next section, retailers' associated revenue (selling price) and related costs (ordering cost, purchasing cost, shortage cost, service investment, and customer satisfaction cost) are determined below.
4.2.1. Selling price
As retailers are in various regions, the selling price of products for each retailer is different. Though the purchasing cost of each retailer is equal, the revenue they earn from their business varies. The unit selling price of the product is yr. Therefore, the revenue of all retailers per cycle is ∑nr=1yrdr.
4.2.2. Ordering cost
The manufacturer orders products whenever the inventory reaches the reorder point. While retailer r orders lr quantity of products from the manufacturer, retailer r bears some ordering cost Ar. Subsequently, the total cost of ordering each retailer per cycle is taken as ∑nr=1Ardrlr.
4.2.3. Purchasing cost
Each retailer buys products from a single manufacturer. Every retailer pays the same purchasing amount to the manufacturer. In addition, retailers purchasing cost is similar to the manufacturer's wholesale price. While the unit purchasing cost is Cp and the ordering product is lr, the entire purchasing cost per cycle is Cp∑nr=1dr.
4.2.4. Shortage cost
As retailers have stochastic safety stock, stockout occurs when the market demand exceeds safety stock. If Xr>Rr, then the shortage quantity for stockout is E[Xr−Rr]+. As safety stock is stochastic, shortage with partial backorder is considered where the backorder rate of retailer r is ϕr,0<ϕr<1. The partial backordered quantity for holding is (1−ϕr)E[Xr−Rr]+. Cs is unit stockout cost and C0sr is the marginal profit from partial backorder quantity.
As per the VMI contract, the manufacturer incurs the holding cost of each retailer. Retailer r holds products for safety stock qrσr√Lr along with the average inventory lr2. Partial backordered quantity is (1−ϕr)E[Xr−Rr]+. If Chr is the unit cost for retailer r, then the entire holding cost is
4.2.6. Investment due to service and cost for customer satisfaction
Retailer r provides some service sr to their customers. For this customer service, the retailer invests some money with investment parameter Ir. Following that, investment due to service is observed as ∑nr=1Irsr22. Customer satisfaction level depends on that provided service. If customers are still unsatisfied, retailer r provides extra facilities for their satisfaction. The cost for customer satisfaction is ∑nr=1(1−sr)2lcr, where lcr is cost regarding customer satisfaction. Therefore, the total cost based on the customer service is given as ∑nr=1[Irsr22+(1−sr)2lcr].
4.2.7. Total profit of retailers
From Eq (4.2), the expected total profit of the retailer per cycle is given as
As expected, the total profit EPc(lr,sr,qr,Nr) of SCM given by Eq (4.3) is a non-linear function of lr, sr, lr, and Nr. Thus, the numerical method is portrayed to analyze the solution.
Optimum solutions of the expected total profit of the supply chain in Eq (4.3) are found by classical optimization. Equation (4.3) is a mixed-integer linear problem. Unique solutions of continuous variables lr,sr,qr, and Nr are obtained using necessary conditions of classical optimization. The values of continuous decision variables are as follows:
A numerical example is provided to validate this model. All the input parameters are extracted from Guchhait and Sarkar [2]. There are four retailers in the SCM, that is, r=4. Other parameters are (Cm,Cp)=$(80,160)/unit, Chm=$0.55/unit, (I1,I2,I3,I4)=$(2,3,5,4), Kf=$0.5/shipment, Kv=$0.13/km, Mc=6000 gallons, (y1,y2,y3,y4)=$(200,205,208,206)/unit, (Cs1,Cs2,Cs3,Cs4)=$(8,7,9,7)/unit, (Ch1,Ch2,Ch3,Ch4)=$(44,44,41.6,40.8)/unit/year, (Tc,Pc)=$(30,60)/unit emission, (Jm1,Jm2,Jm3,Jm4)=(45,46,45,45)km, (L1,L2,L3,L4)=(3,5,5,5)week, (d1,d2,d3,d4)=(300,300,300,300)unit/year, (J1m,J2m,J3m,J4m)=(43,42,45,43)km, (m1,m2,m3,m4)=(50,50,50,50), β=0.5, f=$3.1/unit, (lc1,lc2,lc3,lc4)=(0.3,0.8,0.4,0.5), (A1,A2,A3,A4)=$(10,50,50,50)/order, (a1,a2,a3,a4)=(0.9,0.9,0.9,0.9), and (b1,b2,b3,b4)=(4,4,4,4),(ϕ1,ϕ2,ϕ3,ϕ4)=(0.9,0.9,0.9,0.9),(C0s1,C0s2,C0s3,C0s4)=$(60,70,60,65)/unit, P=1000 unit/year.
Table 4 shows that the optimum results of this study are adequately mentioned. Figures 2–5 shows that the total profit of SCM EPc(lr,sr,qr,Nr) is at a global maximum.
In Guchhait and Sarkar's [2] model, the SCM's total profit was $168,806.93. Figure 1 shows that while the mean value of demand considers a uniform distribution, the proposed research achieved maximum profit compared to the Guchhait and Sarkar [2] model.
5.1. Usefulness of numerical results in practice with the environmental perspective
Total carbon emissions from the entire SCM (Te) are 2378.64 and 2378.63 gallons, respectively, whereas the mean value of demand follows uniform and normal distribution functions, respectively. From Table 5, for a uniform distribution, the production sector emits 90.81%, and the transportation sector emits 9.12% of the total emitted carbon. For the normal distribution function, the production sector emits 90.81%, and the transportation sector emits 9.12% of the total emitted carbon. Numerically, the carbon cap limit of the manufacturer (Mc) was 6000 gallons. Therefore, the total carbon emissions Te are much lower than Mc for both distribution functions. Hence, an extra unused carbon cap is used for trading, contributing to manufacturer revenue.
Table 5.
Interpretation of emitted carbon from production and transportation sector under two distribution functions.
The effect of various parameters from −50% to +50% on the total profit of SCM is discussed in this section. Table 6 lists the numerical results of the sensitivity analysis. Pictorial illustrations of the sensitivity are presented in Figures 6–9.
(i) As soon as the manufacturer's production cost increases towards +50%, the total profit of SCM gradually decreases. The negative percentage change is more than the positive percentage change in production cost.
(ii) The negative and positive percentage changes of the carbon tax from −50% to +50% remain the same. Therefore, an increased ordering cost value implies a decreased value of SCM's total profit.
(iii) The scaling parameter regarding retailers' service investment is less sensitive than other parameters. Maximizing the retailers' service investment specifies that the total profit of SCM gradually diminishes.
(iv) The most sensitive parameter among all parameters is the retailers' selling price of products. This specific parameter is the main factor in raising the total profit of SCM. While the selling price is maximized, the SCM's total profit is increased. In this case, both percentage changes are similar.
(v) The total profit of SCM diminishes while the manufacturer's variable transportation cost rises. This parameter is a little bit sensitive. For this parameter, the positive percentage change is similar to the negative.
(vi) If one increases the cost related to customer satisfaction up to 50%, then the total profit of SCM decreases. Therefore, for this parameter, the negative percentage change equals the positive percentage change.
(vii) The percentage changes in the unit holding cost of retailers show that if one maximizes the unit holding cost, then the total profit of SCM decreases and vice-versa. Both the positive and negative percentage changes of this parameter are the same.
(viii) Within the range from −50% to +50%, changes in the percentage of ordering cost of retailers highlight that the total profit of SCM is changed. If the ordering cost increases within that range, then the total profit of SCM is minimized.
7.
Managerial insights
In this model, the CAPT policy is adapted by considering the environment. The amount of carbon emitted into the air is higher because of heavy transportation during forward and backward logistics. The CAPT policy can control this carbon emission level. In addition, the manufacturer pays an amount for each ton of carbon emitted (carbon tax). The CAPT policy sets the authorized maximum emission limit (i.e., the cap on industries). Using this CAPT policy, the actual carbon emissions can be detected. In addition to the CAPT policy, manufacturers collect utilized products from retailers for recycling. Because of the environmental aspects, the CAPT policy and recycling would be the best options to protect the environment.
Here, the manufacturer implemented the VMI policy. In agreement with this policy, the manufacturer is responsible for meeting the requirements of each retailer, such as maintaining the quantity and quality of the required products from time to time. Under this VMI policy, the manufacturer shares the holding cost with each retailer. Under this contract, retailers do not need to bear any costs for holding finished goods. This would help retailers diminish their costs, as they do not manage the holding costs. Consequently, the industry will benefit if it applies a VMI policy during the business.
8.
Conclusions, limitations, and future works
This research discussed untrustable issues of retailers and their viewpoints within SCM. Because multiple retailers involved in SCM are untrustable, information asymmetry was observed in the system. This study included VMI policy to eliminate the unreliability of the entire system. We analyzed the optimal retailer's lot size, customer service by the retailer, and retailer's reorder point under random demand. The retailer's lead time demand follows two random distribution functions, uniform and normal. Numerical findings show that the proposed study was economically 50.24% more beneficial for SCM than previous studies in the literature. The numerical results proved that this study maximized the supply chain's total profit compared to previous research. This study was beneficial from an environmental perspective. The manufacturer traded an extra carbon cap and earns profits under the CAPT policy. Thus, the CAPT policy was both economically and environmentally beneficial.
This research considered a single type of product. This approach can be extended by considering multiple products [24] and deteriorating products [25,26]. This study is limited to a two-echelon supply chain model. This model can be extended to a multi-echelon supply chain model. This study used a single period. Therefore, the multi-period multi-echelon model is a better extension of this study. In addition, it was considered a player of SCM with equal power. This is another major limitation.
For future works, this research recommended solving this model by applying the Stackelberg technique and expanding by utilizing robust optimization to deal with the unequal power of SCM players or with other methodologies [27]. Advertisement is one of the major tactics used to attract consumer attention to any enterprise. In the future, this research can be broadened by determining promotion effort [28], and price-dependent stochastic demands [29]. In addition, the application of a cross-docking scheme [30], water supply and wastewater collection system (WSWCS) under uncertainty [31], price discount policy [32], Internet of Things [33], and green products [34,35,36] will help achieve development goals.
Use of AI tools declaration
The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.
Acknowledgments
The authors thank the Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia, for funding this research through project number (IF-PSAU-2021/01/18925).
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VMI: vendor-managed inventory; VMI-CS: vendor-managed inventory-consignment stock; CAPT: cap and trade; −: not applicable.
Distribution
Mean
Variance
Expected shortage quantity
(MrLr)
(σr√Lr)
E[Xr−Rr]+
Uniform
(ar+br)Lr2
√(br−ar)212Lr
12√(br−ar)212Lr(√1+q2r−qr)
(ar, br)
Normal
mrLr
σr√Lr
σr√Lr2(√1+q2r−qr)
(mr, σr)
Mean value
rth retailer's
Service given by
Safety stock
Number of
Total profit
of demand
lot size
the retailer r
of retailer
production
of SCM
follows
(lr)
to customers
(qr)
lots (Nr)
EPc(lr,sr,qr,Nr)
(sr)
Uniform
(542,667,
(0.41,0.34,
(0.30,0.87,
(3,2,2,3)
$253,616.50
distribution
686,563)
0.15,0.24)
0.83,0.87)
Normal
(542,667,
(0.41,0.34,
(0.30,0.87,
(3,2,2,3)
$252,483.18
distribution
686,563)
0.15,0.24)
0.83,0.87)
Mean value of demand follows
Carbon emissions by production sector
Carbon emissions by transportation sector
Uniform distribution
2160.00 gallons
218.64 gallons
Normal distribution
2160.00 gallons
218.63 gallons
Parameters
Changes (in%)
Total profit of SCM
Cm
−50
+31.74
−25
+15.37
+25
−14.72
+50
−28.98
f
−50
+0.0001
−25
+0.00008
+25
−0.00008
+50
−0.0001
Ir
−50
+0.0001
−25
+0.00004
+25
−0.00003
+50
−0.00005
yr
−50
−48.66
−25
−24.33
+25
+24.33
+50
+48.66
Kv
−50
+2.06
−25
+1.03
+25
−1.03
+50
−2.06
lcr
−50
+0.0002
−25
+0.0001
+25
−0.0001
+50
−0.0002
Ch
−50
+12.73
−25
+5.86
+25
−5.21
+50
−9.97
Ar
−50
+0.015
−25
+0.007
+25
−0.007
+50
−0.015
Figure 1. Immunohistochemical staining of lymph node micrometastasis (LMM) with CAM5.2 antibody staining: A, B, C, and D, serial sections of LMM positive lymph node, 40X; E, LMM positive lymph node, 100X; F, LMM positive staining for undifferentiated adenocarcinoma, 40X
Figure 2. The lymphatic infiltration detected by immunohistochemical staining with D2–40. A and B, the irregular or slit shaped lymphatic vessels stained by D2–40,100X. C and D, the lymphatic vessels stained by D2–40 and infiltration of tumor cells in lymphatic vessels, 400X
Figure 3. The survival curves of the LMM negative group and positive group by the Log- Rank test of Kaplan-Meier. The survival rate of the LMM positive group showed a clear downward trend