### Mathematical Biosciences and Engineering

2019, Issue 5: 5551-5583. doi: 10.3934/mbe.2019276
Research article Special Issues

# Analysis of a mathematical model with nonlinear susceptibles-guided interventions

• Received: 18 March 2019 Accepted: 06 June 2019 Published: 17 June 2019
• In this paper, we considered a mathematical model describing the nonlinear susceptibles-guided vaccination and isolation strategies, incorporating the continuously saturated treatment. In this strategy, we find that the disease-free periodic solution can always exist, and consequently the control reproduction number can be defined through analyzing the stability of the disease-free periodic solution. Also, we discussed the existence and stability of the positive order-1 periodic solution from two points of view. Initially, we investigated the transcritical and pitchfork bifurcation of the Poincaré map with respect to key parameters, and proved the existence of a stable or an unstable positive order-1 periodic solution near the disease-free periodic solution. For another aspect, by studying the properties of the Poincaré map, we verified the existence of the positive order-1 periodic solution in a large range of the control parameters, especially, we verified the co-existence of finite or infinite countable different positive order-1 periodic solutions. Furthermore, numerical simulations show that the unstable order-1 periodic solution can co-exist with the stable order-1, or order-2, or order-3 periodic solution. The finding implies that the nonlinear susceptibles-triggered feedback control strategy can induce much rich dynamics, which suggests us to carefully choose key parameters to ensure the stability of the disease-free periodic solution, indicating that infectious diseases die out.

Citation: Qian Li, Yanni Xiao. Analysis of a mathematical model with nonlinear susceptibles-guided interventions[J]. Mathematical Biosciences and Engineering, 2019, 16(5): 5551-5583. doi: 10.3934/mbe.2019276

### Related Papers:

• In this paper, we considered a mathematical model describing the nonlinear susceptibles-guided vaccination and isolation strategies, incorporating the continuously saturated treatment. In this strategy, we find that the disease-free periodic solution can always exist, and consequently the control reproduction number can be defined through analyzing the stability of the disease-free periodic solution. Also, we discussed the existence and stability of the positive order-1 periodic solution from two points of view. Initially, we investigated the transcritical and pitchfork bifurcation of the Poincaré map with respect to key parameters, and proved the existence of a stable or an unstable positive order-1 periodic solution near the disease-free periodic solution. For another aspect, by studying the properties of the Poincaré map, we verified the existence of the positive order-1 periodic solution in a large range of the control parameters, especially, we verified the co-existence of finite or infinite countable different positive order-1 periodic solutions. Furthermore, numerical simulations show that the unstable order-1 periodic solution can co-exist with the stable order-1, or order-2, or order-3 periodic solution. The finding implies that the nonlinear susceptibles-triggered feedback control strategy can induce much rich dynamics, which suggests us to carefully choose key parameters to ensure the stability of the disease-free periodic solution, indicating that infectious diseases die out.

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