A model based rule for selecting spiking thresholds in neuron models

  • Received: 01 February 2015 Accepted: 29 June 2018 Published: 01 January 2016
  • MSC : Primary: 37C10, 65L05; Secondary: 92C20.

  • Determining excitability thresholds in neuronal models is of high interest due to its applicability in separating spiking from non-spiking phases of neuronal membrane potential processes. However, excitability thresholds are known to depend on various auxiliary variables, including any conductance or gating variables. Such dependences pose as a double-edged sword; they are natural consequences of the complexity of the model, but proves difficult to apply in practice, since gating variables are rarely measured.
       In this paper a technique for finding excitability thresholds, based on the local behaviour of the flow in dynamical systems, is presented. The technique incorporates the dynamics of the auxiliary variables, yet only produces thresholds for the membrane potential. The method is applied to several classical neuron models and the threshold's dependence upon external parameters is studied, along with a general evaluation of the technique.

    Citation: Frederik Riis Mikkelsen. A model based rule for selecting spiking thresholds in neuron models[J]. Mathematical Biosciences and Engineering, 2016, 13(3): 569-578. doi: 10.3934/mbe.2016008

    Related Papers:

  • Determining excitability thresholds in neuronal models is of high interest due to its applicability in separating spiking from non-spiking phases of neuronal membrane potential processes. However, excitability thresholds are known to depend on various auxiliary variables, including any conductance or gating variables. Such dependences pose as a double-edged sword; they are natural consequences of the complexity of the model, but proves difficult to apply in practice, since gating variables are rarely measured.
       In this paper a technique for finding excitability thresholds, based on the local behaviour of the flow in dynamical systems, is presented. The technique incorporates the dynamics of the auxiliary variables, yet only produces thresholds for the membrane potential. The method is applied to several classical neuron models and the threshold's dependence upon external parameters is studied, along with a general evaluation of the technique.


    加载中
    [1] Lect. Notes Phys., 368 (1990), p5.
    [2] J. Physiol., 213 (1971), 31-53.
    [3] Computational Neuroscience, MIT Press, Cambridge, MA, 2001.
    [4] J. Math. Biol., 67 (2012), 989-1017.
    [5] J. Math. Biol., 67 (2013), 239-259.
    [6] Biophys. J., 1 (1961), 445-466.
    [7] Int. J. Bifurcat. Chaos, 16 (2006), 887-910.
    [8] J. Physiol., 117 (1952), 500-544.
    [9] The MIT Press, 2007.
    [10] Biol. Cybern., 66 (1992), p381.
    [11] Biofizika, 18 (1973), p506.
    [12] Biol. Cybern., 67 (1992), 461-468.
    [13] Biophys. J., 35 (1981), 193-213.
    [14] Proc. IRE, 50 (1962), 2061-2070.
    [15] J. Phys. Soc. Jpn., 41 (1976), 1815-1816.
    [16] Phil. Trans. R Soc. Lond. A, 337 (1991), 275-289.
    [17] $3^{rd}$ edition, Texts in Applied Mathematics, 7, Springer, 2000.
    [18] PLoS Comput. Biol., 6 (2010), e1000850, 16 pp.
    [19] IEEE T. Bio. Med. Eng., 51 (2004), 1665-1672.
    [20] Phys. Rev. E, 90 (2014), 022701.
    [21] in Nonautonomous Dynamical Systems in the Life Sciences, Lecture Nones in Math., 2102, Springer, 2013, 89-132.
  • Reader Comments
  • © 2016 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Metrics

Article views(1716) PDF downloads(490) Cited by(1)

Article outline

Other Articles By Authors

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return

Catalog