Research article Special Issues

Cell growth on electrospun nanofiber mats from polyacrylonitrile (PAN) blends

  • Received: 14 January 2020 Accepted: 12 March 2020 Published: 16 March 2020
  • Nanofiber mats can be produced by electrospinning from diverse polymers and polymer blends as well as with embedded ceramics, metals, etc. The large surface-to-volume ratio makes such nanofiber mats a well-suited substrate for tissue engineering and other cell growth experiments. Cell growth, however, is not only influenced by the substrate morphology, but also by the sterilization process applied before the experiment as well as by the chemical composition of the fibers. A former study showed that cell growth and adhesion are supported by polyacrylonitrile/gelatin nanofiber mats, while both factors are strongly reduced on pure polyacrylonitrile (PAN) nanofibers. Here we report on the influence of different PAN blends on cell growth and adhesion. Our study shows that adding ZnO to the PAN spinning solution impedes cell growth, while addition of maltodextrin/pea protein or casein/gelatin supports cell growth and adhesion.

    Citation: Daria Wehlage, Hannah Blattner, Al Mamun, Ines Kutzli, Elise Diestelhorst, Anke Rattenholl, Frank Gudermann, Dirk Lütkemeyer, Andrea Ehrmann. Cell growth on electrospun nanofiber mats from polyacrylonitrile (PAN) blends[J]. AIMS Bioengineering, 2020, 7(1): 43-54. doi: 10.3934/bioeng.2020004

    Related Papers:

  • Nanofiber mats can be produced by electrospinning from diverse polymers and polymer blends as well as with embedded ceramics, metals, etc. The large surface-to-volume ratio makes such nanofiber mats a well-suited substrate for tissue engineering and other cell growth experiments. Cell growth, however, is not only influenced by the substrate morphology, but also by the sterilization process applied before the experiment as well as by the chemical composition of the fibers. A former study showed that cell growth and adhesion are supported by polyacrylonitrile/gelatin nanofiber mats, while both factors are strongly reduced on pure polyacrylonitrile (PAN) nanofibers. Here we report on the influence of different PAN blends on cell growth and adhesion. Our study shows that adding ZnO to the PAN spinning solution impedes cell growth, while addition of maltodextrin/pea protein or casein/gelatin supports cell growth and adhesion.



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    Acknowledgments



    This study was partly funded by the PhD funds and the HiF funds of Bielefeld University of Applied Sciences.

    Conflict of interest



    All authors declare no conflicts of interest in this paper.

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