Editorial

Escherichia coli Genome-scale metabolic models could guide construction of proof-of-principle strains

  • Received: 24 April 2018 Accepted: 27 April 2018 Published: 03 May 2018
  • Citation: Bashir Sajo Mienda. Escherichia coli Genome-scale metabolic models could guide construction of proof-of-principle strains[J]. AIMS Bioengineering, 2018, 5(2): 103-105. doi: 10.3934/bioeng.2018.2.103

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    [1] Sang YL, Kim HU (2015) Systems strategies for developing industrial microbial strains. Nat Biotechnol 33: 1061–1072. doi: 10.1038/nbt.3365
    [2] Mienda BS (2017) Genome-scale metabolic models as platforms for strain design and biological discovery. J Biom Struc Dyn 35: 1863–1873. doi: 10.1080/07391102.2016.1197153
    [3] O'Brien EJ, Monk JM, Palsson BO (2015) Using genome-scale models to predict biological capabilities. Cell 161: 971–987. doi: 10.1016/j.cell.2015.05.019
    [4] Aziz RK, Khaw VL, Monk JM, et al. (2015) Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC. Front Microbiol 6: 958.
    [5] Thiele I, Palsson BO (2010) A protocol for generating a high-quality genome-scale metabolic reconstruction. Nat Protoc 5: 93–121. doi: 10.1038/nprot.2009.203
    [6] O'Brien EJ, Lerman JA, Chang RL, et al. (2013) Genome-scale models of metabolism and gene expression extend and refine growth phenotype prediction. Mol Syst Biol 9: 693.
    [7] Mienda BS, Shamsir MS, Illias RM (2016) Model-guided metabolic gene knockout of gnd for enhanced succinate production in Escherichia coli from glucose and glycerol substrates. Comput Biol Chem 61: 130–137. doi: 10.1016/j.compbiolchem.2016.01.013
    [8] Mienda BS, Shamsir MS, Illias RM (2016) Model-aided atpE gene knockout strategy in Escherichia coli for enhanced succinic acid production from glycerol. J Biomol Struct Dyn 34: 1705–1716. doi: 10.1080/07391102.2015.1090341
    [9] Mienda BS, Shamsir MS, Illias RM (2015) Model-assisted formate dehydrogenase-O (fdoH) gene knockout for enhanced succinate production in Escherichia coli from glucose and glycerol carbon sources. J Biomol Struct Dyn 34: 2305–2316.
    [10] Sang JL, Lee DY, Kim TY, et al. (2005) Metabolic engineering of Escherichia coli for enhanced production of succinic acid, based on genome comparison and in silico gene knockout simulation. Appl Environ Microbiol 71: 7880–7887. doi: 10.1128/AEM.71.12.7880-7887.2005
    [11] Yim H, Haselbeck R, Niu W, et al. (2011) Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol. Nat Chem Biol 7: 445–452. doi: 10.1038/nchembio.580
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  • © 2018 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
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