Research article Special Issues

Changes in Spontaneous Working-memory, Memory-recall and Approach-avoidance following “Low Dose” Monosodium Glutamate in Mice

  • Received: 06 August 2016 Accepted: 07 September 2016 Published: 06 August 2016
  • The study investigated the effects of ‘low doses’ of monosodium glutamate (MSG) on hippocampal-related (spontaneous working-memory, memory-recall and anxiety) behaviours, and hippocampal glutamate/glutamine levels. A two-trial Y-maze test and 8-arm radial-arm maze spontaneous working-memory test were used to assess the effects of acute and repeated administration of MSG, on novel-arm choice on retrial and spatial working-memory; while anxiety-related behaviors were assessed in the elevated plus maze. In the elevated plus maze, radial-arm maze and Y-maze, MSG administration was associated with significant anxiolytic and memory-enhancing effects at 10 mg/kg (after both acute and repeated dosing); however, higher doses used in this study were associated with significant anxiogenesis and memory retardation. Hippocampal glutamate and glutamine levels did not increase significantly at any of the doses of MSG. In conclusion, MSG administration at low doses was associated with significant changes in hippocampal-dependent behaviours without a concomitant significant shift in hippocampal glutamate/glutamine levels.

    Citation: Olakunle J. Onaolapo, Adejoke Y. Onaolapo, Moses A. Akanmu, Gbola Olayiwola. Changes in Spontaneous Working-memory, Memory-recall and Approach-avoidance following “Low Dose” Monosodium Glutamate in Mice[J]. AIMS Neuroscience, 2016, 3(3): 317-337. doi: 10.3934/Neuroscience.2016.3.317

    Related Papers:

  • The study investigated the effects of ‘low doses’ of monosodium glutamate (MSG) on hippocampal-related (spontaneous working-memory, memory-recall and anxiety) behaviours, and hippocampal glutamate/glutamine levels. A two-trial Y-maze test and 8-arm radial-arm maze spontaneous working-memory test were used to assess the effects of acute and repeated administration of MSG, on novel-arm choice on retrial and spatial working-memory; while anxiety-related behaviors were assessed in the elevated plus maze. In the elevated plus maze, radial-arm maze and Y-maze, MSG administration was associated with significant anxiolytic and memory-enhancing effects at 10 mg/kg (after both acute and repeated dosing); however, higher doses used in this study were associated with significant anxiogenesis and memory retardation. Hippocampal glutamate and glutamine levels did not increase significantly at any of the doses of MSG. In conclusion, MSG administration at low doses was associated with significant changes in hippocampal-dependent behaviours without a concomitant significant shift in hippocampal glutamate/glutamine levels.


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    [1] Maragakis NJ, Rothstein JD (2001) Glutamate Transporters in Neurologic Disease. Arch Neurol 58: 365-370.
    [2] Stanton PK (1996) Long term depression, Long term potentiation, and the sliding threshold for long-term synaptic plasticity. Hippocampus 6: 35-42.
    [3] Meldrum BS (2000) Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 130: 1007S-1015.
    [4] Fagg GE, Foster AC (1983) Amino acid neurotransmitters and their pathways in the mammalian central nervous system. Neurosci 9: 701–719.
    [5] Cotman CW, Monaghan DT, Ottersen OP, et al. (1987) Anatomical organization of excitatory amino acid receptors and their pathways. Trends Neurosci 10: 273-280. doi: 10.1016/0166-2236(87)90172-X
    [6] Peinado JM, Mora F (1986) Glutamic acid as a putative transmitter of the interhemispheric corticocortical connections in the rat. J Neurochem 47: 15498-16003.
    [7] Hlinák Z, Gandalovicová D, Krejcí I (2005) Behavioural deficits in adult rats treated neonatally with glutamate. Neurotox Teratol 27: 465-473. doi: 10.1016/j.ntt.2005.03.006
    [8] Onaolapo OJ, Onaolapo AY, Akanmu MA, et al. (2016) Evidence of alterations in brain structure and antioxidant status following ‘low-dose’ monosodium glutamate ingestion. Pathophysiol (in press). http://dx.doi.org/10.1016/j.pathophys.2016.05.001
    [9] Geha RS, Beiser A, Ren C, et al. (2000) Review of Alleged Reaction to Monosodium Glutamate and Outcome of a Multicenter Double-Blind Placebo-Controlled Study. J Nutr 130: 1058S-1062S.
    [10] National Academy of Sciences, National Research Council (1979) The 1977 Survey of the Industry on the Use of Food Additives: Estimates of Daily Intake. Vol.3, Washington D.C.: National Academy Press.
    [11] Beyreuther K, Biesalski HK, Fernstrom JD, et al. (2007) Consensus meeting: mono sodium glutamate—An update. Eur J Clin Nutr 61: 304-313. doi: 10.1038/sj.ejcn.1602526
    [12] Shi Z, Luscombe-Marsh ND, Wittert GA, et al. (2010) Monosodium Glutamate is not associated with obesity or a greater prevalence of weight gain over 5 years: findings from the Jiangsu Nutrition Study. Br J Nutr 104: 457-463. doi: 10.1017/S0007114510000760
    [13] Insawang T, Selmi C, Cha'on U, et al. (2012) Monosodium glutamate (MSG) intake is associated with the prevalence of metabolic syndrome in a rural Thai population. Nutr Metab (Lond) 9: 50.
    [14] Collison KS, Makhoul NJ, Inglis A, et al (2010) Dietary trans-fat combined with monosodium glutamate induces dyslipidemia and impairs spatial memory. Physiol Behav 99: 334-342. doi: 10.1016/j.physbeh.2009.11.010
    [15] Olvera-Cortes E, Lopez-Vazquez MA, Beas-Zarate C, et al. (2005) Neonatal exposure to MSG disrupts place learning ability in adult rats. Pharmacol Biochem Behav 82: 247-251.
    [16] Wong PT, Neo H, Teo WL, et al. (1997) Deficits in water escape performance and alterations in hippocampal cholinergic mechanisms associated with neonatal monosodium glutamate treatment in mice. Pharmacol Biochem Behav 57: 383-388.
    [17] Frieder B, Grimm VE (1984) Prenatal monosodium glutamate (MSG) treatment given through the mother's diet causes behavioral deficits in rat offspring. Int J Neurosci 23: 117-126.
    [18] Narayanan SN, Paval KJ, Nayak S (2010) Effect of ascorbic acid on monosodium glutamate induced neurobehavioral changes in periadolescent rats. Bratisel Lek Listy 111: 247-252.
    [19] Choi DW (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1: 623-634. doi: 10.1016/0896-6273(88)90162-6
    [20] Ankarcrona M, Dypbukt JM, Bonfoco E (1995) Glutamate induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15: 961-973. doi: 10.1016/0896-6273(95)90186-8
    [21] Olney JW, Wozniak DF, Farber NB (1997) Excitotoxic neurodegeneration in Alzheimer disease. New hypothesis and new therapeutic strategies. Arch Neurol 54: 1234-1240.
    [22] Lemkey-Johnston N, Reynolds WA (1974) Nature and extent of brain lesions in mice related to ingestion of monosodium glutamate: a light and electron microscope study. J Neuropathol Exper Neurol 3: 74-97.
    [23] Takasaki Y, Matsuzawa Y, Iwata S, et al. (1979) Toxicological studies of monosodium L-glutamate in rodents; relationship between routes of administration and neurotoxicity. In: Glutamic Acid: Advances in Biochemistry (Filer LJ. Garattini S. Kare MR. Reynolds WA. Wurtman RJ. Eds.): Raven Press, New York. 255-275.
    [24] Onaolapo OJ, Onaolapo AY (2011) Acute low dose monosodium glutamate retards novelty induced behaviours in male Swiss albino mice. JNBH 3: 51-56.
    [25] Onaolapo AY, Onaolapo OJ, Mosaku TJ, et al. (2013) Histological Study of the Hepatic and Renal Effects of Subchronic Low Dose Oral Monosodium Glutamate in Swiss Albino Mice. BJMMR 3: 294-306. doi: 10.9734/BJMMR/2013/2065
    [26] Falalieieva TM, Kukhars'ky? VM, Berehova TV (2010) Effect of long-term monosodium glutamate administration on structure and functional state of the stomach and body weight in rats. Fiziol Zh 56: 102-110.
    [27] Hodgson AS (2001) Some facts about monosodium glutamate (MSG). Foods Nutr 8.
    [28] Ma MX, Chen YM, He J, et al. (2007) Effects of morphine and its withdrawal on Y-maze spatial recognition memory in mice. Neurosci 147: 1059-1065. doi: 10.1016/j.neuroscience.2007.05.020
    [29] Jung WR, Kim HG, Kim KL (2008) Ganglioside GQ1b improves spatial learning and memory of rats as measured by the Y-maze and the Morris water maze tests. Neurosci Letters 439: 220-225. doi: 10.1016/j.neulet.2008.05.020
    [30] Itoh J, Nabaeshima T, Kameyama T (1990) Utility of an elevated plus maze for the evaluation of nootropics, scopolamine and electro convulsion shock. Psychopharmacol 101: 27-33. doi: 10.1007/BF02253713
    [31] Onaolapo OJ, Onaolapo AY, Akinola OR, et al. (2014) Dexamethasone regimens alter spatial memory and anxiety levels in mice. J Behav Brain Sc 4: 159-167. doi: 10.4236/jbbs.2014.44019
    [32] Onaolapo OJ, Onaolapo AY, Awe EO, et al. (2013) Oral artesunate-amodiaquine combination causes anxiolysis and impaired cognition in healthy Swiss mice. IOSR:JPBS 7: 97-102.
    [33] San Gabriel AM, Maekawa T, Uneyama H, et al. (2007) mGluR1 in the fundic glands of rat stomach. FEBS Lett581: 11191123.
    [34] Uneyama H, Niijima A, San Gabriel A, et al. (2006) Luminal amino acid sensing in the rat gastric mucosa. Am J Physiol Gastrointest Liver Physiol291:G1163-1170.
    [35] Li X, Staszewski L, Xu H, et al. (2002)Human receptors for sweet and umami taste. Proc Natl Acad Sci USA99: 4692-4696.
    [36] Kondoh T, Mallick H.N, Torii K(2009) Activation of the gut-brain axis by dietary glutamate and physiologic significance in energy homeostasis. Am J Clin Nutr 90:832S837S.
    [37] Niijima A (2002) Reflex effects of oral, gastrointestinal and hepatoportal glutamate sensors on vagal nerve activity. J Nutr130:971S973S.
    [38] Kondoh T, Torii K (2008) MSG intake suppresses weight gain, fat deposition and plasma leptin levels in male Sprague–Dawley rats. Physiol Behav 95: 135-144.
    [39] Oleksandra AS, Oleksandr VVT, Falalyeyeva TM, et al. (2014) The efficacy of probiotics for monosodium glutamate-induced obesity: Dietology concerns and opportunities for prevention EPMA J 5(1): 2.
    [40] Tordoff MG, Aleman TR, Murphy MC (2012) No effects of monosodium glutamate consumption on the body weight or composition of adult rats and mice. Physiol Behav 107: 338-345. doi: 10.1016/j.physbeh.2012.07.006
    [41] Park CH, Choi SH, Piaoa Y, et al. (2000) Glutamate and aspartate impair memory retention and damage hypothalamic neurons in adult mice. Toxicol Lett 115: 117-125. doi: 10.1016/S0378-4274(00)00188-0
    [42] Kubo T, Kohira R, Okano T, et al. (1993) Neonatal glutamate can destroy the hippocampal CA1 structure and impair discrimination learning in rats. Brain Res 616: 311-314. doi: 10.1016/0006-8993(93)90223-A
    [43] Morris RG, Anderson E, Lynch GS, et al (1986) Selective impairment of learning and blockade of long-term potentiation by an N methyl-D-aspartate receptor antagonist, AP5. Nature 27: 774-776.
    [44] Onaolapo OJ, Onaolapo AY, Mosaku TJ, et al. (2012) Elevated plus maze and Y-maze behavioural effects of subchronic, oral low dose monosodium glutamate in Swiss albino mice IOSR-JPBS 3: 21-27.
    [45] Shivasharan BD, Nagakannan P, Thippeswamy BS, et al. (2013) Protective Effect of Calendula officinalis L. Flowers Against Monosodium Glutamate Induced Oxidative Stress and Excitotoxic Brain Damage in Rats. Indian J Clin Biochem 28: 292-298.
    [46] Meyer-Gerspach AC, Suenderhauf C, Bereiter L, et al. (2016) Gut Taste Stimulants Alter Brain Activity in Areas Related to Working Memory: a Pilot Study. Neurosignals 24: 59-70. doi:10.1159/000442612.
    [47] Buzescu A, Cristea NA, Chiriac A, et al. (2014) Experimental research on the interactions between some anxiolytics and dietary sodium monoglutamate. Acta Medica Marisiensis 60: 260-264.
    [48] Cortese BM, Phan KL (2005) The role of glutamate in anxiety and related disorders. CNS Spectr 10: 820. doi: 10.1017/S1092852900010427
    [49] Simon AB, Gorman JM (2006) Advances in the treatment of anxiety: targeting glutamate. Neuro Rx 3: 57-68. doi: 10.1016/j.nurx.2005.12.005
    [50] Letizia B, Maricla T, Sara C, et al. (2008) Magnetic resonance imaging volumes of the hippocampus in drug-naive patients with post-traumatic stress disorder without comorbidity conditions. J Psych Res 42: 752-762. doi: 10.1016/j.jpsychires.2007.08.004
    [51] Amiel JM, Mathew SJ (2007) Glutamate and anxiety disorders. Curr Psychiatry Rep 9: 278-283. doi: 10.1007/s11920-007-0033-7
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