Manuscript Topics

Exposure to stress hormones has been shown to cause long-lasting effects on the genome. The epigenetic mechanisms that stress can influence include chromatin remodeling, DNA methylation, histone modification, etc. Stress has also been shown to induce epigenetic changes in various brain structures. Stress provokes the activation of different biological responses in order for the body to return to homeostasis. Such a biological response is DNA methylation. DNA methylation is an epigenetic mechanism that plays a crucial role in activating/ inhibiting transcription. The brain DNA modifications brought on by stress have been linked with a plethora of neurological problems and neuro-related pathologies. PTSD, anxiety, depression, and childhood trauma have been closely studied in association with stress-induced epigenetic changes. Stressful stimuli, such as childhood trauma, have been proven to instigate the development of stress-related disorders. Epigenetic changes have been shown to be a mechanism by which stressors and genome interact, resulting in (among others) DNA modification, and alteration in gene expression and behavior.

The aim of this special issue is to provide a comprehensive overview of stress-induced changes in both animal and human studies. Stress-induced biological changes, epigenetic mechanisms, recent advances, limitations and gaps in current research as well as potential future directions will be analyzed.

Potential topics of interest include, but are not limited to the following:
• Stress-related epigenetic modifications
• Stress-associated epigenetic changes and anxiety
• Stress-associated epigenetic changes and depression
• Stress-associated epigenetic changes and PTSD
• Risk factors for PTSD
• Epigenetics mechanisms and PTSD
• Epigenetics mechanisms and childhood trauma
• Epigenetics mechanisms and depression
• Stress-related disease mechanisms
• Pathophysiology of stress-related disorders

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