Manuscript Topics

Dear colleagues,

Diabetic foot disease remains one of the most devastating and costly complications of diabetes mellitus. It affects up to one-third of individuals with diabetes during their lifetime, and each year, between 9.1 and 26.1 million people worldwide are estimated to develop a diabetic foot ulcer (DFU). These lesions are not only complex to treat, but also carry a considerable burden in terms of morbidity, mortality, and healthcare expenditure.
The natural history of DFUs is sobering: the 5-year mortality rate after developing a DFU is more than double that of patients with diabetes without ulcers. More alarmingly, among those who undergo a diabetes-related amputation, up to 70% die within the following five years—a mortality rate that surpasses that of many types of cancer. Moreover, the recurrence rate of ulcers is strikingly high: about 40% of patients experience a recurrence within the first year, and up to 65% within five years, underscoring the need for prevention-focused strategies.

This Special Issue aims to gather original research and comprehensive reviews on the full spectrum of diabetic foot management, including but not limited to:  
    1. Epidemiology, pathophysiology and risk stratification  
    2. Screening and prevention programs  
    3. Diagnostic strategies (clinical signs, probe-to-bone test, imaging, lab markers)  
    4. Infection management, including osteomyelitis and antibiotic stewardship  
    5. Revascularization, surgery, and adjuvant therapies  
    6. Use of technology (AI, smart sensors, wearable devices) in monitoring and treatment  
    7. Models of multidisciplinary care and health systems innovation  
    8. Patient and caregiver education for ulcer prevention and remission maintenance

We welcome contributions from clinicians, researchers, public health experts, and policy-makers across all disciplines involved in the care of people with diabetes. Special emphasis will be given to work that bridges research and clinical implementation, or that introduces novel strategies to improve ulcer-free survival and quality of life.

We look forward to receiving your submissions.

Keywords for topic: diabetic foot; diabetic foot ulcer; diabetic foot ulcer recurrence; diabetic foot infections; diabetic foot osteomyelitis; diabetic foot treatment; diabetic foot prevention

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