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Skin aging and oxidative stress

Department of Dermatology, Case Western Reserve University Hospitals, Cleveland, OH, USA

Topical Section: Oxidative Stress and Ageing

Skin aging occurs through two main pathways, intrinsic and extrinsic. These pathways have significant interaction in contributing to the aging phenotype, which includes skin laxity, wrinkling, pigmentation irregularities, and the appearance of neoplastic skin lesions. Here, we review the critical role that oxidative stress plays in skin aging, including its effects on signaling pathways involved in skin matrix formation and degradation, proteasome activity, as well as DNA structure. Furthermore, we discuss the recent literature surrounding the prevention and treatment of skin aging. Although current research is suggestive of the role of antioxidants in anti-aging skin therapies, further research is much needed to explore its role in humans.
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References

1. Grassi G, Seravalle G, Turri C, et al. (2003) Impairment of thermoregulatory control of skin sympathetic nerve traffic in the elderly. Circulation 108: 729-735.    

2. Thompson CS, Kenney WL (2004) Altered neurotransmitter control of reflex vasoconstriction in aged human skin. J Physiol (Lond) 558: 697-704.

3. Valko M, Leibfritz D, Moncol J, et al. (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39: 44-84.

4. Robert C, Bonnet M, Marques S, et al. (2015) Low to moderate doses of infrared A irradiation impair extracellular matrix homeostasis of the skin and contribute to skin photodamage. Skin Pharmacol Physiol 28: 196-204.

5. Watson RE, Gibbs NK, Griffiths CE, et al. (2014) Damage to skin extracellular matrix induced by UV exposure. Antioxid Redox Signal 21: 1063-1077.

6. Finkel T (2011) Signal transduction by reactive oxygen species. J Cell Biol 194: 7-15.

7. Watanabe K, Shibuya S, Ozawa Y, et al. (2014) Superoxide dismutase 1 loss disturbs intracellular redox signaling, resulting in global age-related pathological changes. Biomed Res Int 2014: 14016.

8. Murakami K, Inagaki J, Saito M, et al. (2009) Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative. Biochem Biophys Res Commun 382: 457-461.    

9. Weyemi U, Parekh PR, Redon CE, et al. (2012) SOD2 deficiency promotes aging phenotypes in mouse skin. Aging (Albany NY) 4: 116-118.

10. Valko M, Leibfritz D, Moncol J, et al. (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39: 44-84.

11. Kohen R, Nyska A (2002) Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol 30: 620-650.    

12. Fisher GJ, Voorhees JJ (1998) Molecular mechanisms of photoaging and its prevention by retinoic acid: ultraviolet irradiation induces MAP kinase signal transduction cascades that induce Ap-1-regulated matrix metalloproteinases that degrade human skin in vivo. J Investig Dermatol Symp Proc 3: 61-68.

13. Fisher GJ, Datta SC, Talwar HS, et al. (1996) Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature 379: 335-339.

14. Wlaschek M, Briviba K, Stricklin GP, et al. (1995) Singlet oxygen may mediate the ultraviolet A-induced synthesis of interstitial collagenase. J Invest Dermatol 104: 194-198.    

15. Brenneisen P, Briviba K, Wlaschek M, et al. (1997) Hydrogen peroxide (H2O2) increases the steady-state mRNA levels of collagenase/MMP-1 in human dermal fibroblasts. Free Radic Biol Med 22: 515-524.    

16. Nelson KK, Melendez JA (2004) Mitochondrial redox control of matrix metalloproteinases. Free Radic Biol Med 37: 768-784.    

17. Fisher GJ, Quan T, Purohit T, et al. (2009) Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin. Am J Pathol 174: 101-114.    

18. Cooper KD, Neises GR, Katz SI (1986) Antigen-presenting OKM5+ melanophages appear in human epidermis after ultraviolet radiation. J Invest Dermatol 86: 363-370.    

19. Petropoulos I, Conconi M, Wang X, et al. (2000) Increase of oxidatively modified protein is associated with a decrease of proteasome activity and content in aging epidermal cells. J Gerontol A Biol Sci Med Sci 55: B220-227.    

20. Hwang JS, Hwang JS, Chang I, et al. (2007) Age-associated decrease in proteasome content and activities in human dermal fibroblasts: restoration of normal level of proteasome subunits reduces aging markers in fibroblasts from elderly persons. J Gerontol A Biol Sci Med Sci 62: 490-499.    

21. Bulteau AL, Moreau M, Nizard C, et al. (2002) Impairment of proteasome function upon UVA- and UVB-irradiation of human keratinocytes. Free Radic Biol Med 32: 1157-1170.    

22. Widmer R, Ziaja I, Grune T (2006) Protein oxidation and degradation during aging: role in skin aging and neurodegeneration. Free Radic Res 40: 1259-1268.    

23. Barzilai A, Yamamoto K (2004) DNA damage responses to oxidative stress. DNA Repair (Amst) 3: 1109-1115.    

24. Toussaint O, Medrano EE, Von zglinicki T (2000) Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol 35: 927-945.

25. Chen Q, Fischer A, Reagan JD, et al. (1995) Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci U S A 92: 4337-4341.    

26. Oikawa S, Kawanishi S (1999) Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening. FEBS Lett 453: 365-368.

27. Kadunce DP, Burr R, Gress R, et al. (1991) Cigarette smoking: risk factor for premature facial wrinkling. Ann Intern Med 114: 840-844.    

28. Ernster VL, Grady D, Miike R, et al. (1995) Facial wrinkling in men and women, by smoking status. Am J Public Health 85: 78-82.

29. Aizen E, Gilhar A (2001) Smoking effect on skin wrinkling in the aged population. Int J Dermatol 40: 431-433.

30. Yin L, Morita A, Tsuji T (2001) Skin aging induced by ultraviolet exposure and tobacco smoking: evidence from epidemiological and molecular studies. Photodermatol Photoimmunol Photomed 17: 178-183.    

31. Ono Y, Torii K, Fritsche E, et al. (2013) Role of the aryl hydrocarbon receptor in tobacco smoke extract-induced matrix metalloproteinase-1 expression. Exp Dermatol 22: 349-353.    

32. Borska L, Andrys C, Krejsek J, et al. (2016) Influence of dermal exposure to ultraviolet radiation and coal tar (polycyclic aromatic hydrocarbons) on the skin aging process. J Dermatol Sci 81: 192-202.    

33. Traikovich SS (1999) Use of topical ascorbic acid and its effects on photodamaged skin topography. Arch Otolaryngol Head Neck Surg 125: 1091-1098.

34. Shibuya S, Ozawa Y, Toda T, et al. (2014) Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice. Biosci Biotechnol Biochem 78: 1212-1220.

35. Haussler MR, Whitfield GK, Haussler CA, et al. (2016) 1,25-Dihydroxyvitamin D and Klotho: A Tale of Two Renal Hormones Coming of Age. Vitam Horm 100: 165-230.

36. Au L, Meisch JP, Das LM, et al. (2015) Suppression of Hyperactive Immune Responses Protects against Nitrogen Mustard Injury. J Invest Dermatol 135: 2971-2981.

37. Nichols JA, Katiyar SK (2010) Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms. Arch Dermatol Res 302: 71-83.

39. An IS, An S, Park S, et al. (2013) Involvement of microRNAs in epigallocatechin gallate-mediated UVB protection in human dermal fibroblasts. Oncol Rep 29: 253-259.

39. Hwang IS, Kim JE, Choi SI, et al. (2012) UV radiation-induced skin aging in hairless mice is effectively prevented by oral intake of sea buckthorn (Hippophae rhamnoides L.) fruit blend for 6 weeks through MMP suppression and increase of SOD activity. Int J Mol Med 30: 392-400.

40. Watanabe K, Shibuya S, Ozawa Y, et al. (2015) Resveratrol derivative-rich melinjo seed extract attenuates skin atrophy in Sod1-deficient mice. Oxid Med Cell Longev 2015: 391075.

41. Alleva R, Tomasetti M, Battino M, et al. (1995) The roles of coenzyme Q10 and vitamin E on the peroxidation of human low density lipoprotein subfractions. Proc Natl Acad Sci U S A 92: 9388-9391.    

42. Hoppe U, Bergemann J, Diembeck W, et al. (1999) Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors 9: 371-378.

43. Shibuya S, Ozawa Y, Watanabe K, et al. (2014) Palladium and platinum nanoparticles attenuate aging-like skin atrophy via antioxidant activity in mice. PLoS ONE 9: e109288.

Copyright Info: © 2016, Elma D. Baron, et al., licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution Licese (http://creativecommons.org/licenses/by/4.0)

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