Signaling filopodia in avian embryogenesis: formation and function

Margarethe Draga; Martin Scaal; Felicitas Pröls; Margarethe Draga; Martin Scaal; Felicitas Pröls

doi:10.3934/molsci.2016.4.683

AIMS Molecular Science

2016, Volume 3, Issue 4: 683-691. doi: 10.3934/molsci.2016.4.683

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Signaling filopodia in avian embryogenesis: formation and function

Institute of Anatomy II, University of Cologne, Joseph-Stelzmann-Str. 9, 50937 Cologne, Germany

Received: 30 August 2016 Accepted: 18 November 2016 Published: 22 November 2016

In vertebrates and invertebrates specialized cellular protrusions, called signaling filopodia or cytonemes, play an important role in cell-cell communication by carrying receptors and ligands to distant cells to activate various signaling pathways. In the chicken embryo, signaling filopodia were described in limb bud mesenchyme and in somite epithelia. The formation of signaling filopodia depends on the activity of Rho GTPases and reorganization of the cytoskeleton. Here, we give a short overview on the present knowledge on avian signaling filopodia and discuss the molecular basis of cytoskeletal rearrangements leading to filopodia formation.
- chicken; signaling filopodia; cytoskeletal dynamics; actin; microtubules
Citation: Margarethe Draga, Martin Scaal, Felicitas Pröls. Signaling filopodia in avian embryogenesis: formation and function[J]. AIMS Molecular Science, 2016, 3(4): 683-691. doi: 10.3934/molsci.2016.4.683

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Abstract

In vertebrates and invertebrates specialized cellular protrusions, called signaling filopodia or cytonemes, play an important role in cell-cell communication by carrying receptors and ligands to distant cells to activate various signaling pathways. In the chicken embryo, signaling filopodia were described in limb bud mesenchyme and in somite epithelia. The formation of signaling filopodia depends on the activity of Rho GTPases and reorganization of the cytoskeleton. Here, we give a short overview on the present knowledge on avian signaling filopodia and discuss the molecular basis of cytoskeletal rearrangements leading to filopodia formation.

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