<em>Drosophila</em> as a model for chromosomal instability

Dawei Liu; Zeeshan Shaukat; Rashid Hussain; Mahwish Khan; Stephen L. Gregory; Dawei Liu; Zeeshan Shaukat; Rashid Hussain; Mahwish Khan; Stephen L. Gregory

doi:10.3934/genet.2015.1.1

AIMS Genetics

2015, Volume 2, Issue 1: 1-12. doi: 10.3934/genet.2015.1.1

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Drosophila as a model for chromosomal instability

School of Molecular and Biomedical Science, University of Adelaide, North Terrace, Adelaide S.A. 5006, Australia

Received: 30 October 2014 Accepted: 16 December 2014 Published: 25 December 2014

Chromosomal instability (CIN) is a common feature of tumours that leads to increased genetic diversity in the tumour and poor clinical outcomes. There is considerable interest in understanding how CIN comes about and how its contribution to drug resistance and metastasis might be counteracted. In the last decade a number of CIN model systems have been developed in Drosophila that offer unique benefits both in understanding the development of CIN in a live animal as well as giving the potential to do genome wide screens for therapeutic candidate genes. This review outlines the mechanisms used in several Drosophila CIN model systems and summarizes some significant outcomes and opportunities that they have produced.
- aneuploidy,
- cell cycle,
- checkpoint,
- chromosomal instability,
- DNA damage,
- Drosophila,
- JNK,
- metabolism,
- ROS
Citation: Dawei Liu, Zeeshan Shaukat, Rashid Hussain, Mahwish Khan, Stephen L. Gregory. Drosophila as a model for chromosomal instability[J]. AIMS Genetics, 2015, 2(1): 1-12. doi: 10.3934/genet.2015.1.1

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Abstract

Chromosomal instability (CIN) is a common feature of tumours that leads to increased genetic diversity in the tumour and poor clinical outcomes. There is considerable interest in understanding how CIN comes about and how its contribution to drug resistance and metastasis might be counteracted. In the last decade a number of CIN model systems have been developed in Drosophila that offer unique benefits both in understanding the development of CIN in a live animal as well as giving the potential to do genome wide screens for therapeutic candidate genes. This review outlines the mechanisms used in several Drosophila CIN model systems and summarizes some significant outcomes and opportunities that they have produced.

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