Research article

Affinity and avidity models in autoimmune disease

  • In this work, we develop a theoretical model of affinity and avidity in the immune system.The model is based on an extension of the Cubic Ternary Complex (CTC) model of receptor - ligandinteractions to the immunological synapse setting. We use the resulting equation to study how lysiscan occur for a cell exhibiting only self proteins. This general affinity model gives a nice quantitativetool which can be used to explore a nonlinear model of how a T Cell can have a productive interactionwith a MHC-I complex even though the encapsulated peptide fragment is a self protein. The modelbuilt will allow the creation of even more general autoimmune models within the framework of B andT Cell differentiation via cytokine signalling families.

    Citation: James Peterson. Affinity and avidity models in autoimmune disease[J]. AIMS Allergy and Immunology, 2018, 2(1): 45-81. doi: 10.3934/Allergy.2018.1.45

    Related Papers:

    [1] Nafissa Toureche Trouba, Mohamed E. M. Alngar, Reham M. A. Shohib, Haitham A. Mahmoud, Yakup Yildirim, Huiying Xu, Xinzhong Zhu . Novel solitary wave solutions of the (3+1)–dimensional nonlinear Schrödinger equation with generalized Kudryashov self–phase modulation. AIMS Mathematics, 2025, 10(2): 4374-4411. doi: 10.3934/math.2025202
    [2] Islam Samir, Hamdy M. Ahmed, Wafaa Rabie, W. Abbas, Ola Mostafa . Construction optical solitons of generalized nonlinear Schrödinger equation with quintuple power-law nonlinearity using Exp-function, projective Riccati, and new generalized methods. AIMS Mathematics, 2025, 10(2): 3392-3407. doi: 10.3934/math.2025157
    [3] Dumitru Baleanu, Kamyar Hosseini, Soheil Salahshour, Khadijeh Sadri, Mohammad Mirzazadeh, Choonkil Park, Ali Ahmadian . The (2+1)-dimensional hyperbolic nonlinear Schrödinger equation and its optical solitons. AIMS Mathematics, 2021, 6(9): 9568-9581. doi: 10.3934/math.2021556
    [4] Tianyong Han, Ying Liang, Wenjie Fan . Dynamics and soliton solutions of the perturbed Schrödinger-Hirota equation with cubic-quintic-septic nonlinearity in dispersive media. AIMS Mathematics, 2025, 10(1): 754-776. doi: 10.3934/math.2025035
    [5] Abdul Mateen, Ghulam Hussain Tipu, Loredana Ciurdariu, Fengping Yao . Analytical soliton solutions of the Kairat-Ⅱ equation using the Kumar–Malik and extended hyperbolic function methods. AIMS Mathematics, 2025, 10(4): 8721-8752. doi: 10.3934/math.2025400
    [6] Mahmoud Soliman, Hamdy M. Ahmed, Niveen Badra, Taher A. Nofal, Islam Samir . Highly dispersive gap solitons for conformable fractional model in optical fibers with dispersive reflectivity solutions using the modified extended direct algebraic method. AIMS Mathematics, 2024, 9(9): 25205-25222. doi: 10.3934/math.20241229
    [7] Yazid Alhojilan, Islam Samir . Investigating stochastic solutions for fourth order dispersive NLSE with quantic nonlinearity. AIMS Mathematics, 2023, 8(7): 15201-15213. doi: 10.3934/math.2023776
    [8] Emad H. M. Zahran, Ahmet Bekir, Reda A. Ibrahim, Ratbay Myrzakulov . The new soliton solution types to the Myrzakulov-Lakshmanan-XXXII-equation. AIMS Mathematics, 2024, 9(3): 6145-6160. doi: 10.3934/math.2024300
    [9] Da Shi, Zhao Li, Dan Chen . New traveling wave solutions, phase portrait and chaotic patterns for the dispersive concatenation model with spatio-temporal dispersion having multiplicative white noise. AIMS Mathematics, 2024, 9(9): 25732-25751. doi: 10.3934/math.20241257
    [10] Ghazala Akram, Saima Arshed, Maasoomah Sadaf, Hajra Mariyam, Muhammad Nauman Aslam, Riaz Ahmad, Ilyas Khan, Jawaher Alzahrani . Abundant solitary wave solutions of Gardner's equation using three effective integration techniques. AIMS Mathematics, 2023, 8(4): 8171-8184. doi: 10.3934/math.2023413
  • In this work, we develop a theoretical model of affinity and avidity in the immune system.The model is based on an extension of the Cubic Ternary Complex (CTC) model of receptor - ligandinteractions to the immunological synapse setting. We use the resulting equation to study how lysiscan occur for a cell exhibiting only self proteins. This general affinity model gives a nice quantitativetool which can be used to explore a nonlinear model of how a T Cell can have a productive interactionwith a MHC-I complex even though the encapsulated peptide fragment is a self protein. The modelbuilt will allow the creation of even more general autoimmune models within the framework of B andT Cell differentiation via cytokine signalling families.


    In combinatorics, the Catalan numbers are the numbers of Dyck words of length $ 2n $ or the numbers of different ways $ n + 1 $ factors completely parenthesized or the numbers of non-isomorphic ordered trees with $ n + 1 $ vertices or the numbers of monotonic lattice paths along the edges of a grid with $ n \times n $ square cells, which do not pass above the diagonal or the numbers of noncrossing partitions of the set $ \{1, ..., n\} $ and arise in many other counting problems with real-world applications [3,5,7,24,28]. The Catalan-Daehee numbers are defined by assigning $ \sqrt{1-4t}-1 $ instead of $ t $ in the definition of Daehee numbers which play important role in connecting relationship between special numbers [10,16]. Moreover, the generating function of Catalan numbers can be represented by the fermionic $ p $-adic integral on $ \mathbb{Z}_p $ of $ (1-4t)^{\frac{x}{2}} $ and the generating function of Catalan-Daehee numbers can be represented by the $ p $-adic Volkenborn integral on $ \mathbb{Z}_p $ of the same function $ (1-4t)^{\frac{x}{2}} $ [16,17]. Various identities of Catalan-Daehee polynomials have been studied in [5,16,17,29].

    Many scholars in the field of mathematics have worked on degenerate versions of special polynomials and numbers which include the degenerate Stirling numbers of the first and second kinds, the degenerate Bernstein polynomials, the degenerate Bell numbers and polynomials, the degenerate gamma function, the degenerate gamma random variables, and so on [1,2,10,11,12,13,14,15,19,20,30,31]. We can find the motivation to study degenerate polynomials and numbers in the following real-world examples. Suppose the probability of a baseball player getting a hit in a match is p. We wonder if the probability that the player will succeed in the 11th trial after failing 9 times in 10 trials is still $ p $. We can see cases where the probability is less than p because of the psychological burden that the player must succeed in the 11th trial [31].

    In the 1970s, Rota and his collaborators [22,23,24] began to construct a rigorous foundation for the classical umbral calculus, which consisted of a symbolic technique for the manipulation of numerical and polynomial sequences. The umbral calculus has received much attention from researchers because of its numerous applications in many fields of mathematics, physics, chemistry, and engineering [4,6,9,11,13,15,16,20,21,22,23,24,25,26,28]. For instance, the connection between Sheffer polynomials and Riordan array and the isomorphism between the Sheffer groups and the Riordan Groups are proved [25,26]. Recently, Kim-Kim [11] introduced the $ \lambda $-Sheffer sequences and the degenerate Sheffer sequences by substituting $ \lambda $-linear functionals and $ \lambda $-differential operators, respectively, instead of linear functionals and differential operators.

    With these points in mind, in this paper, we first define the degenerate Catalan-Daehee numbers and polynomials and degenerate Catalan-Daehee polynomials of order $ r (\geq 1) $ as one of the generalizations of the degenerate Catalan-Daehee polynomials. It is difficult to study identities related to degenerate Catalan-Daehee polynomials and special polynomials using the p-adic integral on $ \mathbb{Z}_p $ or other properties. Thus, we explore various interesting identities related to the degenerate Catalan-Daehee polynomials of order $ r $ and special polynomials and numbers by using degenerate Sheffer sequences. At the same time we derive the inversion formulas of these identities. Some of them include the degenerate and other special polynomials and numbers such as the degenerate falling factorials, the falling factorials, the degenerate Bernoulli polynomials and numbers of order $ r $, the degenerate Euler polynomials and numbers of order $ r $, the degenerate Daehee polynomials of order $ r $, the degenerate Bell polynomials, etc.

    Now, we give some definitions and properties needed in this paper.

    For any nonzero $ \lambda\in\mathbb{R} $, the degenerate exponential function is defined by

    $ exλ(t)=(1+λt)xλ,eλ(t)=(1+λt)1λ,  (|xλ|1)(see[1017]).
    $
    (1.1)

    By Taylor expansion, we get

    $ exλ(t)=n=0(x)n,λtnn!,(see [1017]),
    $
    (1.2)

    where $ (x)_{0, \lambda} = 1, \ (x)_{n, \lambda} = x(x-\lambda)(x-2\lambda)\cdots(x-(n-1)\lambda), \ (n\ge 1) $.

    The degenerate Bernoulli polynomials and degenerate Euler polynomials of order $ r $, respectively, are given by the generating function

    $ (teλ(t)1)rexλ(t)=n=0B(r)n,λ(x)tnn!, (see [1,1113]),
    $
    (1.3)

    and

    $ (2eλ(t)+1)rexλ(t)=n=0E(r)n,λ(x)tnn!,(see[1,11,13]).
    $
    (1.4)

    We note that $ B^{(r)}_{n, \lambda} = B^{(r)}_{n, \lambda}(0) $ and $ E^{(r)}_{n, \lambda} = E^{(r)}_{n, \lambda}(0) $ $ (n\ge 0) $, which are called the degenerate Bernoulli and degenerate Euler numbers of order $ r $, respectively.

    The degenerate Bernoulli polynomials of the second kind of order $ r $ are defined by the generating function

    $ (tlogλ(1+t))r(1+t)x=n=0b(r)n,λ(x)tnn!,(see [8,11]).
    $
    (1.5)

    When $ x = 0 $, $ b^{(r)}_{n, \lambda} = b^{(r)}_{n, \lambda}(0) $, which are called the degenerate Bernoulli numbers of the second kind of order $ r $.

    The degenerate Daehee polynomials of order $ r $ are defined by the generating function

    $ (logλ(1+t)t)r(1+t)x=n=0D(r)n,λ(x)tnn!,(see [6,11]),
    $
    (1.6)

    where $ \log_\lambda(1+t) = \frac{1}{\lambda}((1+t)^\lambda-1) $ and $ \log_\lambda(e_\lambda(t)) = e_\lambda(\log_\lambda(t)) = t $.

    When $ x = 0 $, $ D^{(r)}_{n, \lambda} = D^{(r)}_{n, \lambda}(0) $, which are called the degenerate Daehee numbers of order $ r $.

    The Bell polynomials are defined by the generating function

    $ ex(et1)=n=0Beln(x)tnn!,(see  [3,15,19,20]).
    $

    Kim-Kim introduced the degenerate Bell polynomials given by the generating function

    $ exλ(eλ(t)1)=l=0Bell,λ(x)tll!,(see  [13]).
    $
    (1.7)

    When $ x = 1 $, $ Bel^{(r)}_{n, \lambda} = Bel^{(r)}_{n, \lambda}(1) $ are called the degenerate Bell numbers.

    For $ n\geq 0 $, it is well known that the Stirling numbers of the first and second kind, respectively are given by

    $ (x)n=nl=0S1(n,l)xl  and  1k!(log(1+t))k=n=kS1(n,k)tnn!,(see  [1,14]),
    $

    and

    $ xn=nl=0S2(n,l)(x)l  and  1k!(et1)k=n=kS2(n,k)tnn!,(see  [1,14]),
    $

    where $ (x)_0 = 1, \; (x)_n = x(x-1)\dots (x-n+1) $, $ (n\geq 1) $.

    Moreover, the degenerate Stirling numbers of the first and second kind, respectively are given by

    $ (x)n=nl=0S1,λ(n,l)(x)l,λ  and 1k!(logλ(1+t))k=n=kS1,λ(n,k)tnn!,(k0),(see  [12,14]),
    $
    (1.8)

    and

    $ (x)n,λ=nl=0S2,λ(n,l)(x)l  and 1k!(eλ(t)1)k=n=kS2,λ(n,k)tnn!,(k0),(see  [12,14]).
    $
    (1.9)

    For $ k \geq 0 $, as an extension of the notion of the degenerate Stirling numbers of the second kind, Kim et al. introduced Jindalrae-Stirling numbers of the second kind by

    $ 1k!(eλ(eλ(t)1)1)k=n=kS(2)j,λ(n,k)tnn!,(see  [18]).
    $
    (1.10)

    From (1.9) and (1.10), we note that

    $ S(2)j,λ(n,k)=nm=kS2,λ(n,m)S2,λ(m,k).
    $
    (1.11)

    Let $ \mathbb{C} $ be the complex number field and let $ \mathcal{F} $ be the set of all power series in the variable $ t $ over $ \mathbb{C} $ with

    $ F={f(t)=k=0aktkk! | akC}.
    $

    Let $ \mathbb{P} = \mathbb{C}[x] $ and $ \mathbb{P}^{*} $ be the vector space all linear functional on $ \mathbb{P} $:

    $ Pn={ P(x)C[x] | degP(x)n},  (n0).
    $

    Then $ \mathbb{P}_n $ is an $ (n+1) $-dimensional vector space over $ \mathbb{C} $.

    Recently, Kim-Kim [11] considered $ \lambda $-linear functional and $ \lambda $-differential operator as follows:

    For $ f(t) = \sum\limits_{k = 0}^{\infty}a_{k}\frac{t^{k}}{k!}\in\mathcal{F} $ and a fixed nonzero real number $ \lambda $, each $ \lambda $ gives rise to the linear functional $ \langle f(t)\; |\; \cdot\rangle_\lambda $ on $ \mathbb{P} $, called $ \lambda $-linear functional given by $ f(t) $, which is defined by

    $ f(t)|(x)n,λλ=an,forall n0,(see  [11]).
    $
    (1.12)

    In particular $ \langle t^{k}\; |\; (x)_{n, \lambda}\rangle_\lambda = n!\delta_{n, k} $, for all $ n, \; k\; \ge 0 $, where $ \delta_{n, k} $ is the Kronecker's symbol.

    For $ \lambda = 0 $, we observe that the linear functional $ \langle f(t)\; | \; \cdot\rangle_0 $ agrees with the one in $ \langle f(t)\; |\; x^n \rangle = a_k $, $ (k\geq0) $.

    For each $ \lambda \in \mathbb{R} $ and each nonnegative integer $ k $, they also defined the differential operator on $ \mathbb{P} $ by

    $ (tk)λ(x)n,λ={(n)k(x)nk,λ,    if   kn,0if   kn,(see[11]).
    $
    (1.13)

    and for any power series $ f(t) = \sum\limits_{k = 0}^{\infty}a_{k}\frac{t^{k}}{k!}\in\mathcal{F} $, $ (f(t))_\lambda(x)_{n, \lambda} = \sum\limits_{k = 0}^n {n \choose k}a_k(x)_{n-k, \lambda}, \ \ \ (n\geq 0) $.

    The order $ o(f(t)) $ of a power series $ f(t)(\ne 0) $ is the smallest integer $ k $ for which the coefficient of $ t^{k} $ does not vanish. The series $ f(t) $ is called invertible if $ o(f(t)) = 0 $ and such series has a multiplicative inverse $ 1/f(t) $ of $ f(t) $. $ f(t) $ is called a delta series if $ o(f(t)) = 1 $ and it has a compositional inverse $ \overline f(t) $ of $ f(t) $ with $ \overline{f}(f(t)) = f(\overline{f}(t)) = t $.

    Let $ f(t) $ and $ g(t) $ be a delta series and an invertible series, respectively. Then there exists a unique sequence $ s_{n, \lambda}(x) $ such that the orthogonality condition holds

    $ g(t)(f(t))k|sn,λ(x)λ=n!δn,k,(n,k0),(see  [11]).
    $
    (1.14)

    The sequence $ s_{n, \lambda}(x) $ is called the $ \lambda $-Sheffer sequence for $ (g(t), f(t)) $, which is denoted by $ s_{n, \lambda}(x) \sim (g(t), f(t))_{\lambda} $.

    The sequence $ s_{n, \lambda}(x) \ \sim \ (g(t), f(t))_{\lambda} $ if and only if

    $ 1g(¯f(t))exλ(¯f(t)) = k=0sk,λ(x)k!tk,(n,k0),(see  [11]).
    $
    (1.15)

    Assume that for each $ \lambda \in \mathbb{R^*} $ of the set of nonzero real numbers, $ s_{n, \lambda}(x) $ is $ \lambda $-Sheffer for $ (g_\lambda(t), f_\lambda(t)) $. Assume also that $ \lim_{\lambda\rightarrow 0}f_\lambda(t) = f(t) $ and $ \lim_{\lambda\rightarrow 0}g_\lambda(t) = g(t) $, for some delta series $ f(t) $ and an invertible series $ g(t) $. Then $ \lim_{\lambda\rightarrow 0}\overline{f}_\lambda(t) = \overline{f}(t) $, where is the compositional inverse of $ f(t) $ with $ \overline{f}(f(t)) = f(\overline{f}(t)) = t $. Let $ \lim_{\lambda\rightarrow 0} s_{k, \lambda}(x) = s_{k}(x) $. In this case, Kim-Kim called that the family $ \{s_{n, \lambda}(x)\}_{\lambda \in \mathcal{R}-\{0\}} $ of $ \lambda $-Sheffer sequences $ s_{n, \lambda} $ is the degenerate (Sheffer) sequences for the Sheffer polynomial $ s_n(x) $.

    Let $ s_{n, \lambda}(x) \sim (g(t), f(t))_\lambda $ and $ r_{n, \lambda}(x)\sim (h(t), g(t))_\lambda $, $ (n\ge 0) $. Then

    $ sn,λ(x)=nk=0zn,krk,λ(x),(n0),  where   zn,k=1k!h(¯f(t))g(¯f(t))(l(¯f(t)))k|(x)n,λλ,(n,k0),(see  [11]).
    $
    (1.16)

    In this section, we define the degenerate Catalan-Daehee polynomials of order $ r $, and derive several identities between the degenerate Catalan-Daehee polynomials of order $ r $ and some other polynomials arising from degenerate Sheffer sequences.

    As is known, the Catalan numbers $ C_{n} $ are given by the generating function

    $ 114t2t=21+14t=n=0Cntn,(see  [5,16,17]).
    $

    The Catalan numbers $ C_{n}^{(r)} $ of order $ r $, as a generalization of Catalan numbers, are given by the generating function

    $ (114t2t)r=(21+14t)r=n=0C(r)ntn,(see  [16,17]).
    $

    Kim-Kim introduced the Catalan-Daehee polynomials which are given by the generating function

    $ 12log(14t)14t1(14t)x2=n=0Cn(x)tn=n=0n!Cn(x)tnn!,(see  [16,17]).
    $
    (2.1)

    When $ x = 0 $, $ \mathfrak{C}_n : = \mathfrak{C}_n (0) $, which are called Catalan-Daehee numbers.

    From (1.6) and (2.1), we note that

    $ n=0Cn(x)tn=12log(14t)14t1(14t)x2=n=0n!Dn,12(x2)(4)ntnn!.
    $

    We introduce the degenerate Catalan-Daehee polynomials $ \mathfrak{C}_{n, \lambda}(x) $ which are given by the generating function

    $ (12logλ(14t)eλ(12logλ(14t))1)exλ(12logλ(14t))=n=0n!Cn,λ(x)tnn!.
    $
    (2.2)

    When $ x = 0 $, $ \mathfrak{C}_{n, \lambda} : = \mathfrak{C}_{n, \lambda} (0) $, which are called degenerate Catalan Daehee numbers.

    When $ \lambda\rightarrow 0 $, we note that $ \mathfrak{C}_{n, \lambda}(x) = \mathfrak{C}_{n}(x) $.

    As a generalization of the degenerate Catalan-Daehee polynomials, we also introduce degenerate Catalan-Daehee polynomials $ \mathfrak{C}_{n, \lambda}^{(r)}(x) $ of order $ r $ are given by the generating function

    $ (12logλ(14t)eλ(12logλ(14t))1)rexλ(12logλ(14t))=n=0n!C(r)n,λ(x)tnn!.
    $
    (2.3)

    When $ x = 0 $, $ \mathfrak{C}^{(r)}_{n, \lambda} : = \mathfrak{C}^{(r)}_{n, \lambda} (0) $, which are called degenerate Catalan Daehee numbers of order $ r $.

    It easy to see that the compositional inverse of $ f(t) = \frac{1}{4}(1-e_\lambda(2t)) $ such that $ f(\overline{f}(t)) = \overline{f}(f(t)) = t $ is

    $ ¯f(t)=12logλ(14t).
    $
    (2.4)

    From(1.15), (2.2), (2.3) and (2.4) we have

    $ n!Cn,λ(x)(eλ(t)1t,14(1eλ(2t)))λ,
    $
    (2.5)

    and

    $ n!C(r)n,λ(x)((eλ(t)1t)r,14(1eλ(2t))λ.
    $
    (2.6)

    Theorem 1. For $ n \in \mathbb{N}\cup \{0\} $, we have

    $ C(r)n,λ(x)=1n!nk=0((nm)(1)m22mkS1,λ(m,k)(nm)!C(r)nm,λ)(x)k,λ.
    $

    Proof. From (1.2), (1.15) and (2.6), we consider the following two Sheffer sequence as follows:

    $ n!C(r)n,λ(x)((eλ(t)1t)r,14(1eλ(2t)))λand (x)n,λ(1,t)λ.
    $
    (2.7)

    From (1.16) and (2.7), we have

    $ n!C(r)n,λ(x)=nk=0zn,k(1)k,λ.
    $
    (2.8)

    From (1.8) and (2.3), we obtain

    $ zn,k=1k!(12logλ(14t)eλ(12logλ(14t))1)r(12logλ(14t))k|(x)n,λλ=12k(12logλ(14t)eλ(12logλ(14t))1)r|(logλ(1+(4t))kk!)λ(x)n,λλ=12knm=k(nm)(4)mS1,λ(m,k)(12logλ(14t)eλ(12logλ(14t))1)r|(x)nm,λλ=nm=k(nm)(1)m22mkS1,λ(m,k)(nm)!C(r)nm,λ.
    $
    (2.9)

    Therefore, from (2.8) and (2.9), we have the desired result.

    The next theorem gives the inversion formula of Theorem 1.

    Theorem 2. For $ n \in \mathbb{N}\cup \{0\} $ and $ r \in \mathbb{N} $, we have

    $ (1)n,λ=nk=0k!r!4k(1)k(nl=k2l(nl)(nl+r)rS2,λ(l,k)S2,λ(nl+r,r))C(r)k,λ(x).
    $

    Proof. From (2.7), we consider the following two degenerate Sheffer sequences

    $ (x)n,λ(1,t)λand n!C(r)n,λ(x)((eλ(t)1t)r,14(1eλ(2t)))λ.
    $
    (2.10)

    From (1.16) and (2.10), we have

    $ (1)n,λ=nk=0~zn,kC(r)k,λ(x).
    $
    (2.11)

    First, by (1.9), we observe that

    $ (eλ(t)1t)r=r!tr(eλ(t)1)rr!=r!m=0(m+r)rS2,λ(m+r,r)tmn!.
    $
    (2.12)

    Then, from (1.2), (1.9), (1.16) and (2.12) we have

    $ ~zn,k=1k!(eλ(t)1t)r(14(1eλ(2t)))k|(x)n,λλ=14k(1)knl=k2lS2,λ(l,k)(nl)(eλ(t)1t)r|(x)nl,λλ=r!4k(1)knl=k2lS2,λ(l,k)(nl)(nl+r)rS2,λ(nl+r,r).
    $
    (2.13)

    Therefore, from (2.11) and (2.13), we have what we want.

    Theorem 3. For $ n \in \mathbb{N}\cup \{0\} $, we have

    $ C(r)n,λ(x)=1n!nk=0(nl=knm=ln!m!(1)m22mlS1,λ(m,l)S2,λ(l,k)C(r)nm,λ)(x)k.
    $

    Proof. We note that

    $ (x)n(1,eλ(t)1)λ
    $
    (2.14)

    because of $ e_\lambda^x(\log(1+t)) = (1+t)^x = \sum\limits_{n = 0}^\infty (x)_n \frac{t^n}{n!} $.

    From (2.6) and (2.14), we consider the following two degenerate Sheffer sequences.

    $ n!C(r)n,λ(x)((eλ(t)1t)r,14(1eλ(2t)))λand (x)n(1,eλ(t)1)λ.
    $
    (2.15)

    From (1.8), (1.9), (1.16) and (2.15), we observe that

    $ n!C(r)n,λ(x)=nk=0zn,k(x)k,
    $
    (2.16)

    and

    $ (eλ(12logλ(14t))1)kk!=l=kS2,λ(l,k)(12logλ(14t))ll!=m=ll=k(1)m22mlS1,λ(m,l)S2,λ(l,k)tmm!.
    $
    (2.17)

    From (1.16) and (2.17), we obtain

    $ zn,k=1k!(12logλ(14t)eλ(12logλ(14t))1)r(eλ(12logλ(14t))1)k|(x)n,λλ=nm=lnl=k(1)m22mlS1,λ(m,l)S2,λ(l,k)(nm)(12logλ(14t)eλ(12logλ(14t))1)r|(x)nm,λλ=nm=lnl=k(1)m22mlS1,λ(m,l)S2,λ(l,k)(nm)(nm)!C(r)nm,λ=nl=knm=ln!m!(1)m22mlS1,λ(m,l)S2,λ(l,k)C(r)nm,λ.
    $
    (2.18)

    From (2.16) and (2.18), we get the desired result.

    The next theorem is the inversion formula of Theorem 3.

    Theorem 4. For $ n \in \mathbb{N}\cup \{0\} $ and $ r \in \mathbb{N} $, we have

    $ (x)n=nk=0k!(nl=knm=l(nm)(1)k2l2kS1,λ(m,l)S2,λ(l,k)b(r)nm,λ)C(r)k,λ(x),
    $

    where $ b^{(r)}_{n, \lambda} $ are the Bernoulli numbers of the second kind of order $ r $.

    Proof. From (2.15), we consider the following two degenerate Sheffer sequences.

    $ (x)n(1,t)λand n!C(r)n,λ(x)((eλ(t)1t)r,14(1eλ(2t)))λ.
    $
    (2.19)

    From (1.16) and (2.19), we have

    $ (x)n=nk=0~zn,kk!C(r)k,λ(x).
    $
    (2.20)

    From (1.5), (1.8), (1.9) and (1.16), we get

    $ ~zn,k=1k!(tlogλ(1+t))r14k(1eλ(2logλ(1+t)))k|(x)n,λλ=(1)k4knl=kS2,λ(l,k)2l(tlogλ(1+t))r|((logλ(1+t))ll!)λ(x)n,λλ=(1)k4knl=kS2,λ(l,k)2lnm=lS1,λ(m,l)(nm)(tlogλ(1+t))r|(x)nm,λλ=nl=knm=l(nm)(1)k2l2kS1,λ(m,l)S2,λ(l,k)b(r)nm,λ.
    $
    (2.21)

    Combining (2.20) and (2.21), we prove the theorem.

    Theorem 5. For $ n \in \mathbb{N}\cup \{0\} $, we have

    (1) $ \rm when $ $ r_1 = r_2 $, $ \mathfrak{C}^{(r_1)}_{n, \lambda}(x) = \frac{1}{n!}\sum\limits_{k = 0}^{n} (-1)^m 2^{2n-k}S_{1, \lambda}(n, k)B^{(r_2)}_{k, \lambda}(x), $

    (2) when $ r_1\neq r_2 $, $ \mathfrak{C}^{(r_1)}_{n, \lambda}(x) = \sum\limits_{k = 0}^{n}\sum\limits_{l = k}^{n} \binom{n}{l} (-1)^l 2^{2l-k} (n-l)! S_{1, \lambda}(l, k)\mathfrak{C}_{n-k, \lambda}^{(r_1-r_2)}B^{(r_2)}_{k, \lambda}(x), $

    where $ B_{k, \lambda}^{(r)}(x) $ are the Bernoulli polynomials of order $ r $.

    Proof. From (1.3), (1.15) and (2.6), we consider two degenerate Sheffer sequences as follows:

    $ n!C(r1)n,λ(x)((eλ(t)1t)r1,14(1eλ(2t)))λand B(r2)n,λ(x)((eλ(t)1t)r2,t)λ.
    $
    (2.22)

    From (1.16) and (2.22), we have

    $ n!C(r1)n,λ(x)=nk=0zn,kB(r2)k,λ(x),
    $
    (2.23)

    From (1.8) and (1.16), we have

    when $ r_1 = r_2 $,

    $ zn,k=1k!12k(logλ(14t))k|(x)n,λλ=12kS1,λ(n,k)(4)n=(1)m22nkS1,λ(n,k),
    $
    (2.24)

    when $ r_1 > r_2 $,

    $ zn,k=1k!(eλ(12logλ(14t))112logλ(14t))r2r112k(logλ(14t))k|(x)n,λλ=12knl=kS1,λ(l,k)(4)l(nl)(12logλ(14t)eλ(12logλ(14t))1)r1r2|(x)nl,λλ=nl=k(1)l22lk(nl)S1,λ(l,k)(nl)!C(r1r2)nk,λ,
    $
    (2.25)

    and when $ r_1 < r_2 $,

    $ zn,k=1k!(eλ(12logλ(14t))112logλ(14t))r2r112k(logλ(14t))k|(x)n,λλ=nl=k(1)l22lk(nl)S1,λ(l,k)(12logλ(14t)eλ(12logλ(14t))1)r1r2|(x)nl,λλ=nl=k(1)l22lk(nl)S1,λ(l,k)(nl)!C(r1r2)nk,λ.
    $
    (2.26)

    Therefore, from (2.23), (2.24), (2.25) and (2.26), we have the desired result.

    The following theorem gives the inversion formula of Theorem 5.

    Theorem 6. For $ n \in \mathbb{N}\cup \{0\} $, we have

    (1) $ {\rm when} $ $ r_1 = r_2 $, $ B^{(r_2)}_{n, \lambda}(x) = \sum\limits_{k = 0}^{n}k!\bigg((-1)^k 2^{n-2k}S_{2, \lambda}(n, k)\bigg)\mathfrak{C}^{(r_1)}_{k, \lambda}(x), $

    (2) $ \rm when $ $ r_1\neq r_2 $, $ B^{(r_2)}_{n, \lambda}(x) = \sum\limits_{k = 0}^{n}(-1)^k k!\bigg(\sum\limits_{l = k}^{n} \binom{n}{l} 2^{l-2k} S_{2, \lambda}(l, k)B_{n-l, \lambda}^{(r_2-r_1)}\bigg)\mathfrak{C}^{(r_1)}_{k, \lambda}(x). $

    Proof. From (2.22), we consider the two degenerate Sheffer sequences as follows:

    $ B(r2)n,λ(x)((eλ(t)1t)r2,t)λand n!C(r1)n,λ(x)((eλ(t)1t)r1,14(1eλ(2t)))λ.
    $
    (2.27)

    From (1.16) and (2.27), we have

    $ B(r2)n,λ(x)=nk=0~zn,kk!C(r1)k,λ(x).
    $
    (2.28)

    And from (1.3), (1.5) and (1.16), we get

    when $ r_1 = r_2 $,

    $ ~zn,k=1k!(1)k4k(eλ(2t)1)k|(x)n,λλ=(1)k22kl=kS2,λ(l,k)2ltll!|(x)n,λλ=(1)k2n2kS2,λ(n,k),
    $
    (2.29)

    when $ r_1 > r_2 $,

    $ ~zn,k=1k!(eλ(t)1t)r1r214k(1eλ(2t))k|(x)n,λλ=(1)k22knl=kS2,λ(l,k)2l(nl)(teλ(t)1)r2r1|(x)nl,λλ=(1)knl=k2l2k(nl)S2,λ(l,k)B(r2r1)nl,λ,
    $
    (2.30)

    and when $ r_1 < r_2 $,

    $ ~zn,k=1k!(teλ(t)1)r2r114k(1eλ(2t))k|(x)n,λλ=(1)knl=k2l2k(nl)S2,λ(l,k)B(r2r1)nl,λ.
    $
    (2.31)

    From (2.28), (2.29), (2.30) and (2.31), we arrive at the desired result.

    Theorem 7. For $ n \in \mathbb{N}\cup \{0\} $ and $ s \in \mathbb{N} $, we have

    $ C(r1)n,λ(x)=1n!nk=0(12k+1nl=kS1,λ(l,k)(4)l(nl)nlm=0m!C(r1)m,λ(nlm)×nlmj=ir2i=0(1)nlm2r2ij2(nlm)S2,λ(j,i)S1,λ(nlm,j))E(r2)k,λ(x),
    $

    where $ E_{n, \lambda}^{(r)}(x) $ are the degenerate Euler polynomials of order $ r $.

    Proof. From (1.4), (1.15) and (2.6), we consider the following two degenerate Sheffer sequences

    $ n!C(r1)n,λ(x)((eλ(t)1t)r1,14(1eλ(2t)))λand E(r2)n,λ(x)((eλ(t)+12)r2,t)λ.
    $
    (2.32)

    From (1.16) and (2.32), we give

    $ n!C(r1)n,λ(x)=nk=0zn,kE(r2)k,λ(x).
    $
    (2.33)

    Observe that

    $ (eλ(12log(14t))+1)r=(eλ(12log(14t))1+2)r=ri=0(ri)(eλ(12log(14t))1)i2ri=ri=0(ri)2rii!j=iS2,λ(j,i)(12)j(log(14t))jj!=ri=0(ri)2riji!j=iS2,λ(j,i)d=jS1,λ(d,j)(4)dtdd!=d=idj=iri=0(1)d2rij+2dS2,λ(j,i)S1,λ(d,j)tdd!.
    $
    (2.34)

    From (1.2), (1.8), (1.16), (2.3) and (2.34), we obtain

    $ zn,k=1k!(eλ(12logλ(14t))+12)r2(12(logλ(14t))eλ(12logλ(14t))1)r1×12k(logλ(14t))k|(x)n,λλ=12k+1nl=kS1,λ(l,k)(4)l(nl)nlm=0m!C(r1)m,λ(nlm)×(eλ(12logλ(14t))+12)r2|(x)nlm,λλ=12k+1nl=kS1,λ(l,k)(4)l(nl)nlm=0m!C(r1)m,λ(nlm)×nlmj=ir2i=0(1)nlm2r2ij+2(nlm)S2,λ(j,i)S1,λ(nlm,j).
    $
    (2.35)

    Therefore, from (2.33) and (2.35), we arrive at the desired result.

    Theorem 8. For $ n \in \mathbb{N}\cup \{0\} $ and $ s \in \mathbb{N} $, we have

    $ E(r2)n,λ(x)=nk=0k!(22k(1)knl=knlm=0(nl)(nlm)2l(1)nlm+1,λnlm+1×S2,λ(l,k)E(r2)m,λ)C(r1)k,λ(x),
    $

    where $ E_{n, \lambda}^{(r)}(x) $ are the degenerate Euler polynomials of order $ r $.

    Proof. From (1.4), (1.15) and (2.5), we consider two degenerate Sheffer sequences as follows:

    $ E(r2)n,λ(x)((eλ(t)+12)r2,t)λand n!C(r1)n,λ(x)((eλ(t)1t)r1,14(1eλ(2t)))λ.
    $
    (2.36)

    From (1.16) and (2.36), we have

    $ E(r2)n,λ(x)=nk=0~zn,kk!C(r1)k,λ(x),
    $
    (2.37)

    and from (1.2), (1.4), (1.9) and (1.16), we get

    $ ~zn,k=(2eλ(t)+1)r2(eλ(t)1t)r114k(1eλ(2t))kk!|(x)n,λλ.=22k(1)knl=kS2,λ(l,k)2l(nl)(eλ(t)1t)r1|(2eλ(t)+1)r2λ(x)nl,λλ=22k(1)knl=k(nl)2lS2,λ(l,k)nlm=0(nlm)E(r2)m,λ(eλ(t)1t)r1|(x)nlm,λλ=22k(1)knl=k(nl)2lS2,λ(l,k)nlm=0(nlm)E(r2)m,λ(1)nlm+1,λnlm+1.
    $
    (2.38)

    From (2.37) and (2.38), we deduce the desired result.

    Theorem 9. For $ n \in \mathbb{N}\cup \{0\} $ and $ s \in \mathbb{N} $, we have

    $ C(r1)nm,λ(x)=1n!nk=0(nm=lml=k(nm)(1)m22ml(nm)!S1,λ(m,l)S2,λ(l,k)C(r1+r2)nm,λ)b(r2)k,λ(x),
    $

    where $ b_{n, \lambda}^{(r)}(x) $ are degenerate Bernoulli polynomials of the second kind of order $ r $.

    Proof. From (1.5), (1.15) and (2.6), we consider the following two degenerate Sheffer sequences

    $ n!C(r1)n,λ(x)((eλ(t)1t)r1,14(1eλ(2t)))λ and  b(r2)n,λ(x)((teλ(t)1)r2,eλ(t)1)λ.
    $
    (2.39)

    From (1.16) and (2.39), we have

    $ n!C(r1)n,λ(x)=nk=0zn,kb(r2)k,λ(x).
    $
    (2.40)

    From (1.8), (1.16) and (2.3), we derive

    $ zn,k=(12logλ(14t)eλ(12logλ(14t))1)r1(12logλ(14t)eλ(12logλ(14t))1)r2|(1k!(eλ(12logλ(14t))1)k)λ(x)n,λλ=nm=lml=k(1)m22mlS2,λ(l,k)S1,λ(m,l)(nm)(12logλ(14t)eλ(12logλ(14t))1)r1+r2|(x)nm,λλ=nm=lml=k(1)m22ml(nm)S1,λ(m,l)S2,λ(l,k)(nm)!C(r1+r2)nm,λ.
    $
    (2.41)

    Therefore, from (2.40) and (2.41), we have the desired result.

    The next theorem is the inversion formula of Theorem 9.

    Theorem 10. For $ n \in \mathbb{N}\cup \{0\} $ and $ s \in \mathbb{N} $, we have

    $ b(r2)n,λ(x)=nk=0k!(nm=kml=k2l2k(nm)S1,λ(m,l)S2,λ(l,k)b(r1+r2)n,λ)C(r1)k,λ(x),
    $

    where $ b_{n, \lambda}^{(r)}(x) $ are degenerate Bernoulli polynomials of the second kind of order $ r $.

    Proof. From (1.8) and (1.9), we observe that

    $ (eλ(2logλ(1+t))1)kk!=l=kS2,λ(l,k)2l(logλ(1+t))ll!=l=kS2,λ(l,k)2lm=lS1,λ(m,l)tmm!=m=kml=k2lS1,λ(m,l)S2,λ(l,k)tmm!.
    $
    (2.42)

    From (2.39), we consider the following two degenerate Sheffer sequences

    $ b(r2)n,λ(x)((teλ(t)1)r2,eλ(t)1)λand n!C(r1)n,λ(x)((eλ(t)1t)r1,14(1eλ(2t)))λ.
    $
    (2.43)

    We have

    $ b(r2)n,λ(x)=nk=0~zn,kk!C(r1)k,λ(x).
    $
    (2.44)

    From (1.5), (1.8), (1.9), (1.16) and (2.42),

    $ ~zn,k=1k!(tlogλ(1+t))r1+r214k(1eλ(2logλ(1+t)))k|(x)n,λλ.=22knm=kml=k2lS1,λ(m,l)S2,λ(l,k)(nm)(tlogλ(1+t))r1+r2|(x)nm,λλ=nm=kml=k2l2k(nm)S1,λ(m,l)S2,λ(l,k)b(r1+r2)n,λ.
    $
    (2.45)

    Thus, from (2.44) and (2.45), we get the desired result.

    Theorem 11. For $ n \in \mathbb{N}\cup \{0\} $ and $ s \in \mathbb{N} $, we have

    $ C(r1)n,λ(x)=1n!nk=0nl=k2lS1,λ(n,l)S2,λ(l,k)D(r2)n,λ(x),
    $

    where $ D_{n, \lambda}^{(r)}(x) $ are degenerate Daehee polynomials of order $ r $.

    Proof. From (1.6), (1.15) and (2.6), we consider the following two degenerate Sheffer sequences

    $ n!C(r1)n,λ(x)((eλ(t)1t)r1,14(1eλ(2t)))λand D(r2)n,λ(x)((eλ(t)1t)r2,eλ(t)1)λ.
    $
    (2.46)

    From (1.16) and (2.44), we have

    $ n!C(r1)n,λ(x)=nk=0zn,kD(r2)k,λ(x),
    $
    (2.47)

    and from (1.8), (1.9) and (1.16), we get

    $ zn,k=1k!(eλ(12logλ(14t))1)k|(x)n,λλ=nm=kml=k2lS1,λ(m,l)S2,λ(l,k)1m!tm|(x)n,λλ=nl=k2lS1,λ(n,l)S2,λ(l,k).
    $
    (2.48)

    From (2.47) and (2.48), we have the desired result.

    The next theorem represents the inversion formula of Theorem 11.

    Theorem 12. For $ n \in \mathbb{N}\cup \{0\} $ and $ s \in \mathbb{N} $, we have

    $ D(r2)n,λ(x)=nk=0k!(nl=k2l2k(1)kk!S1,λ(n,l)S2,λ(l,k))C(r1)k,λ(x),
    $

    where $ D_{n, \lambda}^{(r)}(x) $ are degenerate Daehee polynomials of order $ r $.

    Proof. By (2.46), we consider the following two degenerate Sheffer sequences

    $ D(r2)n,λ(x)((eλ(t)1t)r2,eλ(t)1)λand n!C(r1)n,λ(x)((eλ(t)1t)r1,14(1eλ(2t)))λ,
    $
    (2.49)

    and from (1.16) and (2.49), we get

    $ D(r2)n,λ(x)=nk=0~zn,kk!C(r1)k,λ(x).
    $
    (2.50)

    From (1.8), (1.9), (1.16) and (2.42), we have

    $ ~zn,k=1k!14k(1eλ(2logλ(1+t)))k|(x)n,λλ=(1)k4knm=kml=k2lS1,λ(m,l)S2,λ(l,k)1m!tm|(x)n,λλ=(1)knl=k2l2kS1,λ(n,l)S2,λ(l,k).
    $
    (2.51)

    From (2.50) and (2.51), we obtain the desired result.

    Theorem 13. For $ n \in \mathbb{N}\cup \{0\} $ and $ s \in \mathbb{N} $, we have

    $ C(r)n,λ(x)=1n!nk=0(nm=kml=k(1)m22ml(nm)(nm)!S1,λ(m,l)S1,λ(l,k)C(r)nm,λ)Belk,λ(x),
    $

    where $ Bel_{n, \lambda}(x) $ are degenerate Bell polynomials.

    Proof. From (1.8) and (2.3), we observe that

    $ logλ(1+12logλ(14t))kk!=l=kS1,λ(l,k)(12)l(logλ(14t))ll!=m=kml=k(1)m22mlS1,λ(l,k)S1,λ(m,l)tmm!.
    $
    (2.52)

    From (1.7) and (1.15), we consider the following two degenerate Sheffer sequences as follows:

    $ n!C(r)n,λ(x)((eλ(t)1t)r,14(1eλ(2t)))λand Belk,λ(x)(1,logλ(1+t))λ.
    $
    (2.53)

    From (1.16) and (2.53), we have

    $ n!C(r)n,λ(x)=nk=0zn,kBelk,λ(x).
    $
    (2.54)

    From (1.16), (2.3) and (2.52), we get

    $ zn,k=1k!(12logλ(14t)eλ(12logλ(14t))1)r(logλ(1+12(logλ(14t)))k|(x)n,λλ=nm=kml=k(1)m22mlS1,λ(l,k)S1,λ(m,l)(nm)(12logλ(14t)eλ(12logλ(14t))1)r|(x)nm,λλ=nm=kml=k(1)m22ml(nm)(nm)!S1,λ(m,l)S1,λ(l,k)C(r)nm,λ.
    $
    (2.55)

    Thus, from (2.54) and (2.55), we have the desired result.

    The next theorem is the inversion formula of Theorem 13.

    Theorem 14. For $ n \in \mathbb{N}\cup \{0\} $ and $ s \in \mathbb{N} $, we have

    $ Beln,λ(x)=nk=0k!r!(nm=kml=knmd=0d+rj=r(nm)(nmd)(1)k2l2k(d+r)r×S2,λ(m,l)S2,λ(l,k)S2,λ(d+r,j)S2,λ(j,r)B(r)nmd,λ)C(r)k,λ(x),
    $

    where $ Bel_{n, \lambda}(x) $ are degenerate Bell polynomials.

    Proof. From (2.53), we consider two degenerate Sheffer sequences as follows:

    $ Belk,λ(x)(1,logλ(1+t))λand  n!C(r)n,λ(x)((eλ(t)1t)r,14(1eλ(2t)))λ.
    $
    (2.56)

    From (1.16) and (2.56), we have

    $ Beln,λ(x)=nk=0~zn,kk!C(r)k,λ(x).
    $
    (2.57)

    First, from (1.2), (1.9) and (1.10), we have two identities as follows:

    $ (eλ(2(eλ(t)1))1)kk!=(1)kl=kS2,λ(l,k)2l(eλ(t)1)ll!=m=kml=kS2,λ(l,k)2lS2,λ(m,k)tmm!,
    $
    (2.58)

    and

    $ (eλ(eλ(t)1)t)r=r!tr1r!(eλ(eλ(t)1)1)r=r!1trd=rSJ,λ(d,r)tdd!=r!d=0SJ,λ(d+r,r)td(d+r)!=r!l=0(d+r)rSJ,λ(d+r,r)tdd!,
    $
    (2.59)

    where $ S_{J, \lambda}(n, r) $ are the Jindalrae-Stirling numbers of the second kind [18].

    From (1.11), (1.16), (2.58) and (2.59), we observe that

    $ ~zn,k=1k!(eλ(eλ(t)1)1eλ(t)1)r14k(1eλ(2(eλ(t)1)))k|(x)n,λλ=nm=kml=k(1)k2l2k(nm)S2,λ(m,l)S2,λ(l,k)×(teλ(t)1)r|((eλ(eλ(t)1)1t)r)λ(x)nm,λλ=nm=kml=k(1)k2l2k(nm)S2,λ(m,l)S2,λ(l,k)r!nmd=0(d+r)r×d+rj=rS2,λ(d+r,j)S2,λ(j,r)(nmd)B(r)nmd,λ.
    $
    (2.60)

    From (2.57) and (2.60), we get the desired result.

    In this paper, we introduced the degenerate Catalan-Daehee numbers and polynomials of order $ r $ ($ r\geq 1 $). It was shown that the degenerate Catalan-Daehee polynomials of order $ r $ were expressed based on the degenerate falling factorials, the falling factorials, the degenerate Bernoulli polynomials of order $ r $, the Euler polynomials (of order $ r $), the degenerate Bernoulli polynomials of the second kind of order $ r $, the degenerate Deahee polynomials of order $ r $, and the degenerate Bell polynomials. We also obtained inverse formula for each of them.

    It is difficult to single out where and why these formulas play an important role, but we do not doubt that they will be helpful to researchers in need of these identities. Further research would be related with the degenerate versions of some special combinatorial numbers and polynomials and then contribution in mathematics and physics applications.

    The author would like to thank the referees for the detailed and valuable comments that helped improve the original manuscript in its present form.

    This work was supported by research fund of Kwangwoon University in 2021.

    The authors declare no conflict of interest.

    [1] Peterson JK, Kesson AM, King NJC (2017) A model of auto immune response. BMC Immunol 18 (Suppl 1): 48–65.
    [2] Weiss JM, Morgan PH, Lutz MW, et al. (1996) The cubic ternary complex receptor-occupancy model: I: Model description. J Theor Biol 178: 151–167. doi: 10.1006/jtbi.1996.0014
    [3] Weiss JM, Morgan PH, Lutz MW, et al. (1996) The cubic ternary complex receptor-occupancy model: II: understanding affinity. J Theor Biol 178: 169–182. doi: 10.1006/jtbi.1996.0015
    [4] Weiss JM, Morgan PH, Lutz MW, et al.(1996) The cubic ternary complex receptor-occupancy model: III: resurrecting efficacy. J Theor Biol 181: 391–397.
    [5] Huppa J, Davis M (2013) The Interdisciplinarity Science of T-cell Recognition. Adv Immunol 119: 1–50. doi: 10.1016/B978-0-12-407707-2.00001-1
    [6] Davis MM, Krogsgaard M, Huse M, et al. (2007) T cells as a self-referential sensory organ. Annu Rev Immunol 25: 681–695. doi: 10.1146/annurev.immunol.24.021605.090600
    [7] Kurschus FC,Wörtege S,Waisman A (2011) Modeling a complex disease: Multiple sclerosis. Adv Immunol 110: 111–137. doi: 10.1016/B978-0-12-387663-8.00001-6
    [8] Dendrou CA, Fugger L (2017) Immunomodulation in multiple sclerosis: promises and pitfalls. Curr Opin Immunol 49: 37–43. doi: 10.1016/j.coi.2017.08.013
    [9] Baranzini SE, Oksenberg JR (2017) The genetics of multiple sclerosis: From 0 to 200 in 50 Years. Trends Genet 33: 960–970. doi: 10.1016/j.tig.2017.09.004
    [10] Mitsikostas DD, Goodin DS (2017) Comparing the efficacy of disease-modifying therapies in multiple sclerosis. Mult Scler Relat Dis 18: 109–116. doi: 10.1016/j.msard.2017.08.003
    [11] Geginat J, Paroni M, Pagani M, et al. (2017) The enigmatic role of viruses in multiple sclerosis: Molecular mimicry or disturbed immune surveillance? Trends Immunol 38: 498–512. doi: 10.1016/j.it.2017.04.006
    [12] Roybal KT, Lim WA (2017) Synthetic immunology: Hacking immune cells to expand their therapeutic capabilities. Annu Rev Immunol 35: 229–253. doi: 10.1146/annurev-immunol-051116-052302
    [13] Srivastava S, Riddell SR (2015) Engineering CAR-T cells: Design concepts. Trends Immunol 36: 494–502. doi: 10.1016/j.it.2015.06.004
    [14] Wekerle H (2017) Brain autoimmunity and intestinal microbiota: 100 trillion game changers. Trends Immunol 38: 483–497. doi: 10.1016/j.it.2017.03.008
  • This article has been cited by:

    1. Byung Moon Kim, Taekyun Kim, Jin-Woo Park, Taha Ali Radwan, Sundarapandian Vaidyanathan, Identities on Changhee Polynomials Arising from λ -Sheffer Sequences, 2022, 2022, 1099-0526, 1, 10.1155/2022/5868689
    2. Taekyun Kim, Dae San Kim, Hye Kyung Kim, λ-q-Sheffer sequence and its applications, 2022, 55, 2391-4661, 843, 10.1515/dema-2022-0174
    3. Dorota Bród, Mariola Rubajczyk, Anetta Szynal-Liana, A New Hybrid Generalization of Balancing Polynomials, 2024, 16, 2073-8994, 1397, 10.3390/sym16101397
    4. Sang Jo Yun, Jin-Woo Park, On a generation of degenerate Daehee polynomials, 2025, 10, 2473-6988, 12286, 10.3934/math.2025556
  • Reader Comments
  • © 2018 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Metrics

Article views(5175) PDF downloads(868) Cited by(0)

Figures and Tables

Figures(7)

Other Articles By Authors

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return

Catalog